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Prophylaxis is considered the optimal treatment regimen for patients with severe haemophilia, and may be especially important in the prevention of joint disease. Novel coagulation factor concentrates with prolonged half-lives promise to improve patient treatment by enabling prophylaxis with less frequent dosing. With the call to individualize therapy in haemophilia, there is growing awareness of t
We use a nested-grid version of the GEOS-Chem chemistry transport model, constrained by isoprene emissions from the Model of Emissions of Gases and Aerosols from Nature (MEGAN), and the Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS) bottom-up inventories, to evaluate the impact that surface isoprene emissions have on formaldehyde (HCHO) air-mass factors (AMFs) and vertical column densit
he present study investigated the unique contribution of learning approaches to academic performance, also taking gender differences into account. The participant sample consisted of 476 school pupils (53% girls and 47% boys) from two upper secondary schools in Sweden who completed two self-reported measures related to personality and learning approaches and one cognitive ability test. A series of
Aims: The need to combine active employment and parenthood is a reality for many parents today. Knowing more about which work place factors are associated with better or worse health could help employers to form a work environment that provides optimal conditions to maintain or increase health and work engagement in this group. The aim of this study was to explore possible associations between dif
Micropollutant removal is a key component of the revised Urban Wastewater Treatment Directive (UWWTD) and can be achieved with ozonation. During ozonation, the composition of the wastewater matrix and the targeted treatment level for individual micropollutants or groups of such compounds affect ozone consumption. In this work, it was hypothesized that nitrite scavenging, the point of dosing (befor
Accurate, high-resolution global land use and land cover (LULC) mapping is crucial for environmental monitoring, but remains challenging when relying solely on multispectral data. Most existing global LULC mapping studies rely exclusively on multispectral observations, and even those that incorporate synthetic aperture radar (SAR) data often fail to fully exploit the information it provides. SAR p
Hydraulic balancing is key to ensure proper operation of the heating system. When the heating system is not hydraulically balanced, heat is unevenly distributed across dwellings resulting in a wide temperature spread, overheating, and consequently, wastage of energy. In this paper, we study to which extent hydraulic imbalance affects the thermal energy demand of buildings. Furthermore, key variabl
The art of medicine in the semi-urban and poorly literate medieval Nordic countries was essentially a craft. Those skilled in medicine learned their profession by being apprenticed to people who were more experienced and knowledgeable. But unlike other crafts, such as that of the potter or the carpenter, one could not practice just any way. One could not start from scratch with one’s lump of clay
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
Bakgrund/Syfte: Inom allmänpsykiatrin i Sverige behandlas personer med komplexa psykiatriska behov. Det innebär bland annat begränsningar i att delta i vardagens aktiviteter och samhällslivet. Att få stöd med detta kan möjliggöra ett liv värt att leva trots psykisk ohälsa, i enlighet med arbetsterapi. Flexible Assertive Community Treatment (FACT) är en återhämtningsinriktad integrerad vård- och st
INTRODUCTION: Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease-modifying treatments emerge. Speech-based digital biomarkers offer scalable options for remotely capturing speech-derived functional changes associated with early cognitive decline, but validation across real-world populations remains limited.METHODS: We evaluated the speech biomarker for cogni
PurposeCombination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.Materials and methodsThis prospective study e
This research approaches public administration reform in China from a domestic perspective. Whereas recognizing that the mechanisms behind the nature differ from the principle of New Public Management (NPM) of Anglo-Saxon tradition, the reform initiatives are similar. Municipal governments were encouraged to carry out NPM Reform towards governance model since 1998 to serve dual-purpose. That is st
Our main purpose has been to describe and compare two community's ways of organising and executing the social welfare sectors drug and alcohol abuse programs. We also wanted to explain the similarities and differences we found with the help of an organisations theoretical perspective. A second purpose has been to try to find out if the difference affects the clients possibility to receive equa
Utförandet av radikal prostatektomi, det vill säga borttagande av prostatakörteln vid prostatacancer, har tills nyligen utförts antingen med traditionell öppen kirurgi eller med laparoskopisk kirurgi, så kallad titthålskirurgi. I slutet av 1990-talet introducerades emellertid ett tredje alternativ för utförande av detta ingrepp, nämligen den robotassisterade kirurgin. Användandet av denna typ av k
As the observer of international peace and security, the UNSC has the power to decide upon what constitutes of a threat to world peace. By adopting Resolutions, the UNSC creates binding decisions that must be pursued by all members of the UN. Article 103 UN states that the UN Charter prevail over any other treaty obligation, why the EU must follow the decisions of the UNSC due to the obligations o
The notion of corporate violations of human rights is gaining ground. Using an inductive method, this report explores the level of responsibility of multinational enterprise for violations of human rights law committed by business partners and affiliates, i.e. the ''imputability''. The topic is important as the ability to reconstruct the organizational structure provides corporate
Following the Bosman verdict from the ECJ in 1995, FIFA, the governing body of football, had to change its rules for the status and transfer of players to bring them in line with EC law. With the threat of an outright prohibition decision against the international transfer system under the EC Competition rules, FIFA reached an agreement with the Commission, in March 2001, on the principles for the
