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Massively parallel sequencing (MPS) methods are increasingly applied in forensic casework. However, adequate validation guidelines are lacking. In this work, we describe our in-house validation of the ForenSeq DNA Signature Prep Kit (Verogen) for analysis of ancestry- and phenotype-informative SNPs. We also discuss in-house validation of MPS assays in general terms. When validating the SNP assay,
The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-q
The effect of lesions of two excitatory afferent pathways on the cellular damage in the hippocampus following complete cerebral ischaemia was investigated in the rat Lesions transecting the perforant path led to a significant decrease in cellular damage in the hippocampal CA1 region ipsilateral to the lesion as compared to the contatterai side and to control. Lesions of the fimbria-fornix, on the
Throughout history, the stars have provided humans with ever more information about our world, enabling increasingly accurate systems of navigation in addition to fuelling some of the greatest scientific controversies. What information animals have evolved to extract from a starry sky and how they do so, is a topic of study that combines the practical and theoretical challenges faced by both astro
In the following study, using highly-developed remote sensing methodologies, a historical over-ten-year study of the LULC phenomenon of the Khorezm Oasis was conducted. The analysis provides valuable insights about agricultural change, water management policies and the alteration of LULC in the region, including several processes, changes in plants and irrigation levels, population density and gro
Accurate maps of past land cover and human land use are necessary for studying the impact of anthropogenic land-cover changes, such as deforestation, on the climate. The maps of past land cover should ideally be separated into naturally occurring vegetation and human-induced changes, thereby enabling the quantification of the effect of human land use on the past climate. We developed a Bayesian hi
Taking stance towards any topic, event or idea is a common phenomenon on Twitter and social media in general. Twitter users express their opinions about different matters and assess other people’s opinions in various discursive ways. The identification and analysis of the linguistic ways that people use to take different stances leads to a better understanding of the language and user behaviour on
Land use allocation (LUA) is of prime importance for the development of urban sustainability and resilience. Since the process of planning and managing land use requires balancing different conflicting social, economic, and environmental factors, it has become a complex and significant issue in urban planning worldwide. LUA is usually regarded as a spatial multi-objective optimization (MOO) proble
Environmental changes over time and across different regions profoundly affect agriculture, forestry, water management, public health, and ecosystems. Therefore, monitoring these fluctuations is crucial for informing decision-making and developing strategies for long-term sustainability. While ground-based methods provide valuable insights into environmental dynamics, they are inherently limited i
Childhood stunting is a serious global public health issue that exhibits local spatial variations. Previous studies have used traditional statistical methods to identify stunting risk factors, and little is known about the application and usefulness of spatial machine learning techniques in identifying localized stunting risk factors based on complex datasets. This study assesses the performance o
Hydrological modelling is essential for effective water resources management, as it represents complex physical processes through mathematical equations to improve our understanding of the water cycle. FLEXG is a glacio-hydrological model that has been successfully applied and found to perform well in glacierized regions. This study seeks to improve the capability of classical FLEXG model for glac
Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and biocl
Boreal forests have a large impact on the global greenhouse gas balance and their soils constitute an important carbon (C) reservoir. Mature boreal forests are typically a net CO2 sink, but there are also examples of boreal forests that are persistent CO2 sources. The reasons remain often unknown, presumably due to a lack of understanding of how biotic and abiotic drivers interact to determine the
Historically, companies have communicated taxes as a burden, as the benefits provided by governments are not perceived to be in proportion to their payments. With sustainable development becoming central in many policy areas, new discourses including ‘fair’ or ‘sustainable’ tax have become omnipresent in public talk on taxes. This paper analyzes tax discourses in corporate annual reports within thHistorically, companies have communicated taxes as a burden, as the benefits provided by governments are not perceived to be in proportion to their payments. With sustainable development becoming central in many policy areas, new discourses including ‘fair’ or ‘sustainable’ tax have become omnipresent in public talk on taxes. This paper analyzes tax discourses in corporate annual reports within th
Uppsatsen handlar om ogiltigförklaring och skadestånd inom ramen för ämnet tvister om uppsägnings- och avskeds giltighet. Uppsatsen använder en kombination av rättsdogmatisk och rättsanalytisk metod. Syftet med uppsatsen är att klargöra, problematisera och jämföra gällande rätt med LAS-utredningens- och överenskommelsens förslag inom ramen för uppsatsens ämne. Syftet är vidare att analysera potent
Modern democracies face many challenges including declining voter turnout and growing mistrust towards political representatives. An increased trend among representative democracies facing these challenges is to introduce different direct democratic instruments. The aim of this thesis is to find what explains the introduction of the national citizens’ initiatives in Finland. During the last few de
