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Different rights regarding poor relief – a comparison between the level of reasonable living standards for financial support for the elderly and financial assistanceIn 2003, financial support for the elderly (ÄFS) was introduced in Sweden, which shifted the responsibility for older people in need of financial support from the municipalities to the state. Prior to the reform, the target group recei
Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av
Introduction: The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF-McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology. Aim: Discuss missed opportunities and the methodological approach of the ISTH Guideline in contrast to how GRADE was previ
OBJECTIVES: Small extracellular vesicles (EVs) contain various signaling molecules, thus playing a crucial role in cell-to-cell communication and emerging as a promising source of biomarkers. However, the lack of standardized procedures impedes their translation to clinical practice. Thus, we compared different approaches for high-throughput analysis of small EVs transcriptome.METHODS: Small EVs w
Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103 - cDC2s and LysoDCs in the subepithelia
Adolescence and emerging adulthood are key developmental stages with high risk for trauma exposure and the development of mental and substance use disorders (SUDs). The aim of this study was to compare the clinical profiles of adolescents (aged 12-17 years) and emerging adults (aged 18-25 years) presenting for treatment of posttraumatic stress disorder (PTSD) and SUD. Design/methodology/approach:
Background: Previous reports have suggested higher rates of mortality and amputation for female patients in acute lower limb ischemia (ALI). The aims of the present study were to investigate if there is a difference in mortality, amputation, and fasciotomy between the sexes. Methods: A retrospective cohort study of consecutive patients undergoing index revascularization for ALI between 2001 and 20
Electrical resistivity tomography (ERT) is a potential-based method for detecting internal erosion in the core of embankment dams using the electrodes installed outside. This study aims at evaluating the practical capability of ERT monitoring for detecting internal defects in embankment dams. A test embankment dam with in-built well-defined defects was built in Älvkarleby, Sweden, to assess differ
BackgroundChildren and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.MethodsFatigue was assessed 1235 times for 425
Introduction: The current standard treatment for endometrial cancer is a laparoscopic hysterectomy with adnexectomies and bilateral sentinel node resection. A retroperitoneal vNOTES sentinel node resection has several theoretical potential advantages. These include being less invasive, leaving no visible scars, operating without Trendelenburg, and therefore offering the anesthetic advantage of eas
In this essay I argue that with too few alternative approaches, the strong feminist epistemological habit of attending to the political utility of art risks placing representations of subjective narratives whose emancipatory qualities might be unclear or doubtful out of scholarly reach. Feminist art historian Irit Rogoff discusses how feminist art historians are inclined to acknowledge visual repr
Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for
The fate of soil organic matter (OM) is determined by its microbial use for growth or respiration. Many environmental factors influence microbial OM use, including the presence of contaminants and toxins in the environment, such as heavy metals. We evaluated short- and long-term responses of microbial processes to metal contamination by estimating biomass concentrations and growth rates of bacteri
This article analyses the claims of contemporary disabilityrights activists mobilising in a context where de facto second-class citizenship co-exists with legal and political declarationsabout the rights of disabled people. As an empirical case,it focuses on the blog ‘Full Participation.Now’, which wasinitiated by disability rights activists in Sweden. Drawing uponcitizenship research, the article
Objective: This study evaluated, in a Swedish setting, the cost effectiveness of fenfluramine (FFA) as an add-on to standard of care (SoC) for reducing seizure frequency in Dravet syndrome, a severe developmental epileptic encephalopathy. Methods: Cost effectiveness of FFA+SoC compared with SoC only was evaluated using a patient-level simulation model with a lifetime horizon. Patient characteristi
The executive committee of the European Society for the clinical evaluation of balance disorders meets annually to address equilibrium problems that are not well understood. This is a review paper on discussions in the latest meeting we held. Materials and methods: Seeing patients with vestibular disorders who end up depending on visual information as part of their compensation process is a common
Little is known about the fate and uptake of nanoplastics (NPs) in natural ecosystems, mainly due to analytical limitations in measuring NPs in complex environmental matrices. Our aim was to quantitatively assess the transport, fate and biological uptake of NPs in freshwater ecosystems by using replicated wetland mesocosms and gold-doped polystyrene nanoparticles. We showed that 97% of the NPs wer
Charge-dependent two- and three-particle correlations measured in Xe–Xe collisions at sNN=5.44 TeV are presented. Results are obtained for charged particles in the pseudorapidity range |η|
Crop pests, such as aphids and bark beetles, represent a big challenge for agriculture worldwide. Due to their high adaptability and more suitable conditions because of climate change, they can thrive on a large number of hosts. One of the strategies to control the population of these pests in agricultural areas is the use of pheromones, either to lure them, repel them or to attract predators as a
