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PURPOSE: To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality in patients with ovarian cancer up to 10 years after diagnosis.EXPERIMENTAL DESIGN: We used unpublished survival time data for 2,242 patients from two case-control studies and extended survival time data for 4,314 patients from previously reported studies. All participants had been screened for deleterious germlin

The separation of abiotic and biotic factors affecting populations and communities is an important step in understanding how climate change can influence ecological processes, but quantifying their relative contribution to community changes is a challenge. We assessed the effect of temperature and species interactions on the population dynamics of a forest bird community with a hierarchical dynami

The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasc

Popular Abstract in Swedish Sedimentära bergarter såsom t.ex. sandstenar och lerskiffrar, bildas genom att lösa sediment (t.ex. sand och lera) ”bakas” hårda när de sjunker ned i jordskorpan. Anledningen till att många lagerföljder rör sig nedåt i jordskorpan beror till viss del på de ovanliggande sedimentens tyngd, men är i huvudsak ett resultat av de platt-tektoniska rörelser som hela tiden påverPost-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone

Background The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and w

This study uses the Swedish register of prescribed drugs, merged with the Survey of Living Conditions (the ULF), to analyze the socioeconomic gradient in drug utilization. It finds a significant education gradient (but no income gradient) in individual drug utilization. Whereas the education gradient for men is quantitative in its orientation (education affects number of drugs used), the gradient

Popular Abstract in Swedish Avinstitutionaliseringen av den psykiatriska vården har medfört att personer med funktionshinder p.g.a. en psykisk sjukdom numera huvudsakligen bor och erbjuds vård ute i samhället. I Sverige har få systematiska studier genomförts som undersöker livssituationen för individer med en allvarlig psykisk sjukdom som bor ute i samhället. Att drabbas av en sjukdom som schizofrThis 18-month follow-up study investigated needs for care and support, quality of life and social network in individuals with schizophrenia or a schizoaffective disorder living in the community and in contact with psychiatric services. The validity of Antonovsky's sense of coherence (SOC) measure was also examined. At baseline 120 patients were interviewed and 94 of these participated in the follo

Interleukin-16 (IL-16) functions as a regulator of T-cell growth and acts as an inducer of cell migration. The aim of this study was to determine whether IL-16 measured in human carotid plaques was associated with symptoms (eg, stroke, transient ischemic attack, or amaurosis fugax), markers of plaque stability, and postoperative cardiovascular events.

Here, we present an unusual approach of modifying the growth pattern of electroactive bacteria for improving their communication with electrodes. Cells of a known exoelectrogen, Shewanella oneidensis MR-1, were treated with cisplatin, a drug that inhibits cell division but forces the cells to grow longer resulting in a characteristic elongated growth. Such elongated cells showed up to a 5-fold imp

Objective: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. Methods: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January 2006 and December 2007. Pre-operative data included: demographics, American Soc

Widespread negative correlations between summertime-mean temperatures and precipitation over land regions are a well-known feature of terrestrial climate. This behavior has generally been interpreted in the context of soil moisture atmosphere coupling, with soil moisture deficits associated with reduced rainfall leading to enhanced surface sensible heating and higher surface temperature. The prese

Genome wide association studies (GWAS) identify susceptibility loci for complex traits, but do not identify particular genes of interest. Integration of functional and network information may help in overcoming this limitation and identifying new susceptibility loci. Using GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We

Background: The aim was to investigate whether the effects of major risk factors for ischemic stroke were modified by long-term exposure to air pollution in Scania, southern Sweden. Methods: Cases were defined as first-ever ischemic strokes in patients born between 1923 and 1965 during 2001-2006 (n = 7,244). Data were collected from The Swedish National Stroke Register (Riks-stroke) and the Malmo

1. The rising levels of atmospheric carbon dioxide concentration ([CO2]) and temperature have the potential to substantially affect the terrestrial water and energy balance by altering the stomatal conductance and transpiration of trees. 2. Many models assume decreases in stomatal conductance and plant water use under rising [CO2], which has been used as a plausible explanation for the positive g

Objective The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of SLE. Methods The classification criteria were derived from