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Osteoinduction can be enhanced by combining scaffolds with bone morphogenic protein-2 (BMP-2). However, BMP's are known to also cause bone resorption. This can be controlled using bisphosphonates like zoledronic acid (ZA). In this study, we produced two different scaffolds containing silk-fibroin, chitosan, agarose and hydroxyapatite (HA) with and without bioactive glass. The aims of the study wer
Many of the established Swedish crime writers write for both adults and young readers. These authors are successful in the two literary market segments that are dominating the contemporary Swedish book market: crime literature and children’s literature. Can certain developed trademarks in their authorship for adults be used in order to market books for other age groups and to what extent do the au
BACKGROUND: Acute dyspnea affects a large heterogeneous patient group with high mortality and readmission rates.PURPOSE: To investigate if cardiometabolic biomarkers and clinical characteristics predict readmission and death in patients hospitalized for acute dyspnea.METHODS: 65 dyspnea patients at a general internal medicine ward were followed for six months. The combined endpoint was readmission
Objective: The aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life. Methods: In a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identifie
This thesis deals with epitaxial growth and optical properties of semiconductor nanowires with implications and insights about materials for solar cells. The chapters leading up to the papers give a broader background and an introduction to the field and include nanowires and their synthesis, semiconductor properties, solar cell operational principles, light interaction with a nanowire array, and
Context: Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with PAH. Objectives: This randomized, placebo-controlled, double-blind, crossover study aimed to evaluate the effects of regular, low-dose, extended-release (ER) morphine for PAH-associated chronic breathlessness. Methods: Participants w
Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 ind
A compact combined sewer overflow (CSO) treatment unit is set up and evaluated in pilot-scale. The pilotplant consisted of flocculation, coagulation and a microsieving system followed by a disinfection unit with either O3 or ClO2. Efficiency of the pilot-plant was evaluated with respect to reduction of Escherichia coli, coliform bacteria and intestinal enterococci as well as removal of biocides. R
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between t
Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros
The mission of the Swedish government’s National Commission on Substance Abuse was to analyze the access to substance abuse treatment and to clarify the division of responsibilities between health care and social services. As a part of this assignment a special analysis was performed on commitment to involuntary care. Involuntary commitment due to substance abuse has during many years been regulat
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over
In this study, steady-state laminar natural convection of Cu and TiO 2 nanofluids inside different enclosures is numerically investigated. Natural convection is concerned due to a temperature difference between the hot and cold
BACKGROUND: There is no consensus on best content, set-up, category of involved healthcare professionals or duration of rehabilitation-programs for patients with chronic musculoskeletal pain, and outcomes show varying results. Individual care regimes for sub-groups of patients have been proposed.AIM: To describe the type of interventions used in a physiotherapist-led, rehabilitation-program for pa
