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The Amazon has always been a strategic region because of its rich variety in natural resources. Its global interest is spreading across levels and scales, influenced by the increasing demand for fossil fuels and biodiesel and the threat of climate change. Neoliberal practices continue privatizing and exploiting the Amazon´s resources regardless the Indigenous communities’ interests. These communit
Behavior and social interactions are key features to determine the phenotype of an organism. Observing behavioral manifestations give insides on a fundamental level of how inner mechanisms work. But how is it possible to predict behavior in a way, such that it can be quantify and analyzed? One traditional strategy is to annotate the behavior by hand. Observing the animals and making notes about th
To stay within our planet’s limits and reach the United Nation’s Sustainable Development Goals, there is an urgent need to rethink our current and dominant systems. This thesis focuses on the food system, in particular, and explores how an overarching turnaround in the way we produce and consume food has the potential to trigger and steer a greater transition towards sustainability. However, this
A search is presented for direct top squark pair production using events with at least two leptons including a same-flavour opposite-sign pair with invariant mass consistent with the boson mass, jets tagged as originating from -quarks and missing transverse momentum. The analysis is performed with proton-proton collision data at collected with the ATLAS detector at the LHC in 2012 corresponding to
Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in
The Early Toarcian Oceanic Anoxic Event (T-OAE) represents one of the major alterations of the carbon cycle of the Mesozoic period. Despite being globally recognized, and particularly represented within the Tethys realm, its expression in the sedimentary record is highly variable depending on the studied section, which suggests local environmental factors exert a major control on the resulting lit
Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven immunosuppression, e.g., through CD25(+) regulatory T cells. We addressed this question in a mouse model of mesothelioma by depleting or reconstituting CD25(+) regulatory T cells in combination with two different chemotherapeutic drugs. We found that the effi
Contributing to the design update phase of the European Spallation Source ESS-scheduled to start operation in 2019-a test beamline is under construction at the BER II research reactor at Helmholtz Zentrum Berlin (HZB). This beamline offers experimental test capabilities of instrument concepts viable for the ESS. The experiments envisaged at this dedicated beamline comprise testing of components as
The advent of new technologies for single-cell RNA sequencing analyses has resulted in the discovery that the myeloid compartment in the tumor microenvironment (TME) is far more complex than previously appreciated, and that intrinsic and extrinsic factors in the TME highly influence the immunosuppressive or active states of these cell types. There is now a need to develop multiplex assays to ident
The global shift in the food system towards more sustainable diets has made legumes such as chickpeas, lentils and beans increasingly important due to their nutritional and environmental benefits. But despite these benefits that they offer, their consumption remains relatively low. A key reason for this, is the digestive discomfort they cause such as bloating and flatulence alongside reduced miner
Background Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. The aim of the Primary Oral Insulin Trial (POInT) was to evaluate the efficacy and safety of daily high-dose oral insulin to prevent the development of islet autoantibodies and diabetes. Methods In this randomised, controlled, primary prevention trial, genetic screening in seven obstetric and
The International Bladder Cancer Group (IBCG) has proposed a prognostic model for intermediate risk (IR) non-muscle invasive bladder cancer (NMIBC) for clinical decision-making. We applied the IBCG IR model in a population-based Swedish setting in patients with primary IR NMIBC diagnosed 2013-2014 in BladderBaSe 2.0. Patients were stratified into low-risk (unifocal and tumour size < 3 cm) and inte
Introduction Endometriosis is a chronic, inflammatory and oestrogen-dependent disease frequently causing infertility. Assisted reproductive technologies (ART) are often required to achieve pregnancy, especially in women with advanced endometriosis. To date, there is no randomised controlled trial (RCT) exploring reproductive outcomes after first-line surgery followed by ART versus first-line ART i
The aim of this phenomenological study was to explore what role teachers at introductory programmes (SFI-schools) play in the integration of immigrants, how the teachers experience their work and what they feel about the situation in which their students, the immigrants, are. To what extent and in what way do the teachers contribute to facilitating the integration of the immigrant students? The s
New options are needed to reduce the impact of motor vehicles on climate change and declining fossil fuel resources. Cars which are fueled by hydrogen could be a sustainable method of transportation if suitable technologies can be devised to produce hydrogen in an environmentally benign manner along with the provision of the necessary fueling infrastructure. This paper assesses size, space, and co
IntroductionThe Multidimensional Pain Inventory (MPI) is frequently used in the assessment of chronic pain. Three subgroups have been derived from MPI: Adaptive Coper (AC), Dysfunctional (DYS) and Interpersonally Distressed (ID). The primary aim of was to examine whether outcome of Interdisciplinary Multimodal Pain Rehabilitation Programs (IMMRPs) differed across the MPI subgroups.MethodsChronic p
Alternative reproductive tactics (ARTs) have provided valuable insights into how sexual selection and life history trade-offs can lead to variation within a sex. However, the possibility that tactics may constrain evolution through intralocus tactical conflict (IATC) is rarely considered. In addition, when IATC has been considered, the focus has often been on the genetic correlations between the A
Introduction Although various lipid and non-lipid analytes measured by nuclear magnetic resonance (NMR) spectroscopy have been associated with type 2 diabetes, a structured comparison of the ability of NMR-derived biomarkers and standard lipids to predict individual diabetes risk has not been undertaken in larger studies nor among individuals at high risk of diabetes. Research design and methods C
