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Our society is moving towards renewable resources, where biomass, rich incarbohydrates, is producing chemicals and fuel. However, there are severallimitations when it comes to valorisation of the carbohydrates from renewablebiomass. One major hurdle is the over-functional nature of carbohydrates, making them difficult to process by conventional chemistry. Carbohydrate activeenzymes can help overco
Antibody microarrays have emerged as an important tool within proteomics, enabling multiplexed protein expression profiling in both health and disease. The design and performance of antibody microarrays and how they are processed are dependent on several factors, of which the interplay between the antibodies and the solid surfaces plays a central role. In this study, we have taken on the first com
En kort sammanställning i tidningen Neurolog i Sverige av våra två artiklar som presenterar prevalensen av kardiovaskulär sjukdom och typ 2 diabetes i olika kognitiva sjukdomar. Här visar vi att Alzheimer's sjukdom och Lewykroppssjukdom, de två vanligaste neurodegenerativa sjukdomarna, har en signifikant lägre förekomst av både kardiovaskulär sjukdom och typ 2 diabetes jämfört med vaskulär demens.Here we presented a review of our two articles presenting the prevalence of cardiovascular disease and diabetes in neurocognitive disorders; Alzheimer's disease, vascular dementia, mixed dementa and Lewy body disease. Cardiovascular disease and diabetes showed a significantly lower prevalence among cases with Alzheimer's disease and Lewy body disease, both neurodegenerative disorders, compared to
The flat periwinkles, Littorina fabalis and L. obtusata, comprise two sister gastropod species that have an enormous potential to elucidate the mechanisms involved in ecological speciation in the marine realm. However, the molecular resources currently available for these species are still scarce. In order to circumvent this limitation, we used RNA-seq data to characterize the transcriptome of fou
This study investigates how related variety in the regional employment mix affects the innovation output of a region. Departing from the idea of recombinant innovation, previous research has arguedthat related variety enhances regional innovation as inter-industry knowledge spillovers occur more easily between different but cognitively similar industries. This study combines a
Who produces scientific and technical knowledge these days? What type of knowledge is being produced and for what purposes? Why are firms and governments funding research and development? This chapter studies the role of knowledge production (especially R&D activities) in the innovation process from an innovation system perspective. It examines how governments and public agencies in different
Objective: Novel, highly effective disease-modifying therapies have revolutionized multiple sclerosis (MS) care. However, evidence from large comparative studies on important safety outcomes, such as cancer, is still lacking. Methods: In this nationwide register-based cohort study, we linked data from the Swedish MS register to the Swedish Cancer Register and other national health care and census
BACKGROUND: Adolescent depression is one of the largest health issues in the world and there is a pressing need for effective and accessible treatments. OBJECTIVE: This trial examines whether affect-focused internet-based psychodynamic therapy (IPDT) with therapist support is more effective than an internet-based supportive control condition on reducing depression in adolescents. METHODS: The tria
Aim: There is a lack of authorised medicines for paediatric patients and improved drug development is necessary. The aim of this study was to evaluate the need for infrastructure and support for paediatric clinical trials in Sweden. Methods: A web-based survey was sent to doctors and nurses involved in the care of neonates, children and adolescents assessing the current situation and future needs
I den här boken får du en introduktion till tillit som ledningsfilosofi. Grunden är forskning och boken riktar sig till såväl forskare som praktiskt verksamma i offentlig sektor. Många anställda i offentlig sektor vittnar om hur detaljstyrning, överdriven formalism och felriktad mätning hindrar dem från att göra ett gott arbete. De upplever att verksamheten styrs och leds med fjärrkontroll och med
Mainstream option valuation theory relies implicitly on the assumption that latent states (such as stochastic volatility) and parameters are perfectly known, an assumption that is dubious in many ways. Computing the value of options under the assumption of perfect knowledge will typically introduce bias. Correcting for the bias is straightforward but can be computationally expensive. Fourier-base
Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin gene. The expanded polyglutamine (polyQ) repeat of the encoded protein leads to protein misfolding and aggregation, resulting in increased neuronal cell death. DNAJ co-chaperones play a crucial role in transferring misfolded/unfolded proteins to HSP70 chaperones, which play an essential role for protein folding. Here, we
Service meshes factor out code dealing with inter-micro-service communication. The overall resilience of a cloud application is improved if constituent micro-services return stale data, instead of no data at all. This paper proposes and implements application agnostic caching for micro services. While caching is widely employed for serving web service traffic, its usage in inter-micro-service comm
