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Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD‐L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab‐paclitaxel. How
Liquid biopsy allows assessment of multiple analytes, providing temporal information with potential for improving understanding of cancer evolution and clinical management of patients. Although liquid biopsies are intensely investigated for prediction and response monitoring, preanalytic variables are of primary concern for clinical implementation, including categories of collection method and sam
Control charts have typically been constructed using estimators obtained under assumptions of data independence and a given distribution of data. Here, I deal with cases in which neither of these conditions are satisfied. In particular, I consider the case of data obtained from a first-order autoregressive (AR(1)) time series model that have been contaminated by outlying process observations. I fi
Despite uneventful primary surgery, patients with cleft palate may experience velopharyngeal insufficiency (VPI) and hypernasal speech. Videoradiography of velopharynx is a commonly used method to visualize velopharyngeal function and a velopharyngeal flap is often used to counteract VPI. The aim of this study was to investigate whether the frontal projection on videoradiography plays a role in th
Purpose: To study the relationships between absorbed dose to penile base structures and erectile dysfunction (ED) in patients treated with ultrahypofractionated (UHF) radiation therapy (RT) or conventionally fractionated (CF) RT for prostate cancer. Methods and Materials: This dose-response study comprises 673 patients (57%) of the 1180 per-protocol patients included in the HYPO-RT-PC trial (media
Background: The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures to the brain and heart as well as augmenting cerebral blood flow and end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot studies in out-of-hospital cardiac arrest patients have not shown impr
Background: Inferior placement of a femoral stem is predictive for early loosening and failure, but does restoration of the original hip anatomy benefit the function and survival of a total hip replacement? Methods: Seventy-five patients with primary unilateral hip osteoarthritis operated with an uncemented anatomical stem were randomized for either standard or modular stems. We used 50 ABG II ste
Event marketing can be seen as an effective tool building a brand in a retail context since it can enhance brand awareness, brand identity and brand image. This, since it provides experiences stimulating consumers´ five senses adjusted to today's experience demands of consumers. Event marketing is effective catching consumers attention in today's media noise compared to traditional adverti
Background and Aims: Incisional hernia development is a frequent long-term sequel after open abdomen treatment. This report describes a novel technique, the vacuum-assisted wound closure and permanent onlay mesh–mediated fascial traction for temporary and final closure of the open abdomen, with the intention to decrease incisional hernia rates. Primary aim was to evaluate incisional hernia develop
Forest fire is known as an important natural hazard in many countries which causes financial damages and human losses; thus, it is necessary to investigate different aspects of this phenomenon. In this study, performance of four models of linear and quadratic discriminant analysis (LDA and QDA), frequency ratio (FR), and weights-of-evidence (WofE) was investigated to model forest fire susceptibili
The relationship between field measurements of vegetation in a semi arid region and NDVI from the 1 km NOAA AVHRR was investigated within this study. The Hoanib catchment in the northwestern Namibia was chosen as study area. The field measurements were carried out during the month of February 1999. Different NDVI values and combinations of NDVI were used and it was found that the integrated NDVI u
This paper has its starting point with the discrepancy between the ICPD Plan of Action and the Millennium Development Goals with regards to their separate emphasis on the importance of family planning services as a reproductive health component. The population problem can be looked upon from various theoretical schools. This paper examines the sharply contrasting views of economists, on the one ha
Background: Participatory research has been described to improve the relevance of research findings for the society in terms of quality of healthcare services and other public benefits. Nevertheless, there is limited guidance on how to conduct participatory research, and especially in relation to persons living in residential care facilities. To make the voices of this group heard, we therefore ta
Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for treatment of tics in children and young people with Tourette syndrome or chronic tic disorder. Methods: This multicentre, parallel group, single-blin
Popular Abstract in Swedish Oberoende av om det är i ett samhälle, datornätverk eller organen i en mänsklig kropp, så är behovet av kommunikation stort i en komplex miljö. Eftersom den komplicerade människokroppen är beroende av kommunikation för att reglera funktioner, skickas otaliga mängder signaler oavbrutet. För att signalerna skall vara meningsfulla så måste de kunna tas emot och behandlas. Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. Since an estimated 50% of all clinical drugs act on 30 known GPCRs, the rem
Background: Japan lacks efficient assessment tools for occupational balance (OB) in people with mental illness (MI). Aims/objectives: We investigated the test–retest reliability and construct validity of a Japanese version of the Satisfaction with Daily Occupations and Occupational Balance (SDO-OB-J) for people with MI. Methods: SDO-OB-J interviews were conducted twice at a 2-week interval. Result
