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BACKGROUND: As recently pinpointed by a genome-wide association study the serine/threonine kinase 39 (STK39) is a candidate gene for hypertension. This kinase is strongly implicated in sodium reabsorption by the kidney through its modulating effect on furosemide-sensitive and thiazide-sensitive channels. The aim of our study was to test the effects of the STK39 rs35929607A>G polymorphism on blood

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Moraxella catarrhalis is a Gram-negative human mucosal commensal and pathogen. It is a common cause of exacerbation in chronic obstructive pulmonary disease (COPD). During the process of infection, host colonization correlates with recognition of host molecular patterns. Importantly, in COPD patients with compromised epithelial integrity the underlying extracellular matrix is exposed and provides

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The outer membrane protein A (OmpA) family contains an evolutionary conserved domain that links the outer membrane in Gram-negative bacteria to the semi-rigid peptidoglycan (PG) layer. The clinically significant pathogen Pseudomonas aeruginosa carries several OmpA family proteins (OprF, OprL, PA0833, and PA1048) that share the PG-binding domain. These proteins are important for cell morphology, me

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Given the polarized political context in Peru that was provoked by the inclusion of LGTBIQ+ identities in the official school curriculum, this study analyzes the meanings that students of pedagogy in Lima ascribe to tolerance and respect towards gay and lesbian people, and how these meanings inform their pedagogical practices. Based on two focus groups and eight individual interviews grounded in s

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This essay suggests that the conceptualization of strategic communication as a field uniting several disciplines was an important step forward, but progress in absolute terms has been disappointing so far. Individual researchers open up new avenues of exploration and regularly arrive at answers to questions internally consistent with their respective perspectives. But the body of reasonably verifi

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The last years of turbulence on the market caused by the pandemic and geo-political tensions have led to supply disruptions for many companies. The purpose of this study was to investigate how digital purchasing practices and trust are impacted in the supply chain due to increased turbulence in the environment. This was carried out through an interview study with buyers and sellers in supply chain

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PID controller design is considered where optimal controller parametersare found with constraint on maximum sensitivity and robustness withregard to cone bounded static nonlinearity acting on the plant.

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The invasive yellow-fever mosquito Aedes aegypti preferentially feeds on human blood. A new study finds that human-biting in this important disease vector might just be an unfortunate side effect of breeding in human-stored water.

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Background: The primary aim of this paper is to describe the design of a project evaluating the effects of using a research-based strategy for managing housing adaptations (HAs). The evaluation targets clients' perspectives in terms of activity, participation, usability, fear of falling, fall incidence, use of mobility devices, and health-related quality of life, and determines the societal effect