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Overuse of the psychoactive analgesics’ opioids and gabapentinoid drugs in patients having surgery for nerve entrapment disorders

Knowledge about risks for overuse of psychoactive analgesics in patients having primary surgery for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE), or both, is limited. We investigated if patients with those nerve entrapment disorders have a higher risk of overuse of psychoactive analgesics (i.e., opioids and gabapentinoid drugs) before, after, and both before and after surgery than

Coeliac disease : what can we learn from prospective studies about disease risk?

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study comple

Management of Acute Lower Limb Ischemia Without Surgical Revascularization – A Population-Based Study

Objectives: To evaluate outcomes of management without surgical revascularization in patients with acute lower limb ischemia (ALI) in a population-based setting. Design: Retrospective observational population-based study. Materials: Patients from Malmö, Sweden, hospitalized for ALI between 2015 and 2018. Methods: In-hospital, surgical, radiological, and autopsy registries were scrutinized for desc

Carbohydrates – a scoping review for Nordic Nutrition Recommendations 2023

Background: Dietary carbohydrates are a major source of energy in the Nordic and Baltic countries. The health effects of different types of carbohydrates vary and there is a need to update the evidence regarding specific carbohydrates and their effects on health-related outcomes. Objective: The aim of this scoping review was to describe the evidence for the role of total carbohydrates (fiber exclu

Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study : a mediation analysis

PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of

The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies

Sex-limited morphs can provide profound insights into the evolution and genomic architecture of complex phenotypes. Inter-sexual mimicry is one particular type of sex-limited polymorphism in which a novel morph resembles the opposite sex. While inter-sexual mimics are known in both sexes and a diverse range of animals, their evolutionary origin is poorly understood. Here, we investigated the genom

Development of Single Nanowire Optoelectronic Devices

Semiconductor nanowires (NW) have been of interest to optoelectronics research for several decades due to the unique optical effects resulting from their geometry. Today, NWs are fabricated from a wide range of materials, ranging from Si to III-Vs and emerging materials like metal-halide perovskites (MHPs). Among NW devices, single NW devices are of special interest because they offer both a usefu

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms : JSH-MPN-R18 subanalysis

Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive

Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective I

Micro-cavity optimization for single ion fluorescence detection

This thesis describes the work done on two open access microcavities that aims at detecting single rare-earth ions for quantum information applications. The initial microcavity faced mechanical instability due to its geometry, which limited robust design possibilities due to the 25 mm diameter space of the helium bath cryostat. A Purcell enhancement of 2.2 was realized for nanoparticles at 2.1 K,

Association Between the EAT-Lancet Reference Diet and Gestational Diabetes Mellitus : A Mini-Review

Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that seriously endangers maternal and infant health, posing a medical and economic burden worldwide. Several dietary patterns have been recommended for women of childbearing age, demonstrating a positive role in preventing and managing GDM. However, these dietary patterns may not fully take environmental factors into account

A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal ab

Nano-XRF of lung fibrotic tissue reveals unexplored Ca, Zn, S and Fe metabolism : a novel approach to chronic lung diseases

Synchrotron-radiation nano-X-Ray Fluorescence (XRF) is a cutting-edge technique offering high-resolution insights into the elemental composition of biological tissues, shedding light on metabolic processes and element localization within cellular structures. In the context of Idiopathic Pulmonary Fibrosis (IPF), a debilitating lung condition associated with respiratory complications and reduced li

Marketing machines at work : performing e-commerce by assembling, adjusting, and maintaining a complex market device

This paper aims to explore and conceptualise the marketing work of e-commerce managers. It draws on an ethnographically inspired study involving 21 e-commerce managers and approaches marketing work as a set of socio-material practices. The analysis shows that the marketing work of e-commerce managers centres on assembling, adjusting, and maintaining ‘marketing machines’ – complex market devices de

Clinical and epidemiological characteristics of Legionnaires' disease in Southern Sweden, a population-based study

BACKGROUND: The study aimed to describe all diagnosed cases of Legionnaire's disease (LD) in south Sweden, regarding incidence, patient characteristics, diagnostics, outcomes, and infection control investigations.METHODS: This population-based retrospective study was conducted in Skåne, on patients with LD between 2011-2021. Inclusion criteria were positive polymerase chain reaction (PCR) for L. p

Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr

Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity: Phage detection triggers the toxSAS activity to shut down viral production. We show that the toxSAS FaRel2 inspects the tRNA acceptor stem to specifical