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Pressure enabled organic reactions via confinement between layers of 2D materials

Confinement of reactants within nanoscale spaces of low-dimensional materials has been shown to provide reorientation of strained reactants or stabilization of unstable reactants for synthesis of molecules and tuning of chemical reactivity. While few studies have reported chemistry within zero-dimensional pores and one-dimensional nanotubes, organic reactions in confined spaces between two-dimensi

Put a bet on it : Can self-funded commitment contracts curb fitness procrastination?

We investigate the use of a highly scalable intervention to help individuals achieve their physical activity goals: self-funded commitment contracts. Using a randomised experiment, we compare the effect of soft (non-incentivised) and hard (incentivised) contracts among 1629 members of a gym in Stockholm, Sweden. We find a significant positive impact of being offered a hard contract on monthly visi

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms : JSH-MPN-R18 subanalysis

Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive

Longitudinal changes in cardiovascular disease–related proteins in welders

Objective: Occupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is unknown. Here, we aimed to identify changes in proteins associated with cardiovascular disease in relation to exposure to welding fumes. Methods: Data were obtained from two timepoints six years apart for 338 non-smoking men (171 welders, 167 controls); o

Micro-cavity optimization for single ion fluorescence detection

This thesis describes the work done on two open access microcavities that aims at detecting single rare-earth ions for quantum information applications. The initial microcavity faced mechanical instability due to its geometry, which limited robust design possibilities due to the 25 mm diameter space of the helium bath cryostat. A Purcell enhancement of 2.2 was realized for nanoparticles at 2.1 K,

Associations between bioaerosols, lung function work-shift changes and inflammatory markers : A study of recycling workers

Objective We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. Methods Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of

Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty

Aim: To analyse the association between bone turnover markers and bone mass in children and young adults. Methods: This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum

Transport through a resonator-coupled double quantum dot

Nanoscale systems coupled to superconducting circuits offer a platform to study a variety of research questions ranging from more fundamental investigations on the quantum nature of light interacting with matter to more application-oriented ones such as quantum computing and communication. These hybrid systems have thus gained a great deal of attention in the community in the recent years and have

Decoupled sound and amplitude modes in trapped dipolar supersolids

We theoretically investigate elementary excitations of dipolar quantum gases across the superfluid to supersolid phase transition in a toroidal trap. We show how decoupled first sound, second sound, and Higgs modes emerge by following their origin from superfluid modes across the transition. The structure of these excitations reveals the interplay between crystal and superfluid oscillations. Our r

Clinical validation of a biopsy-based six-gene signature prognostic for aggressive prostate cancer

Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue. Methods: MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason

Associations of Prenatal Mercury Exposure and PUFA with Telomere Length and mtDNA Copy Number in 7-Year-Old Children in the Seychelles Child Development Nutrition Cohort 2

BACKGROUND: Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) variations are linked to age-related diseases and are associated with environmental exposure and nutritional status. Limited data, however, exist on the associations with mercury exposure, particularly early in life.OBJECTIVE: We examined the association between prenatal mercury (Hg) exposure and TL and mtDNAcn in 1,145 S

Computational Approaches for Antimicrobial Peptide Delivery

Peptides constitute alternative molecules for the treatment of infections caused by bacteria, viruses, fungi, and protozoa. However, their therapeutic effectiveness is often limited by enzymatic degradation, chemical and physical instability, and toxicity toward healthy human cells. To improve their pharmacokinetic (PK) and pharmacodynamic (PD) profiles, novel routes of administration are being ex

Detecting the dimensionality of genuine multiparticle entanglement

Complex forms of quantum entanglement can arise in two qualitatively different ways: either between many qubits or between two particles with higher-than-qubit dimension. While both the many-qubit frontier and the high-dimension frontier are well established, state-of-the-art quantum technology is becoming increasingly able to create and manipulate entangled states that simultaneously feature many

Fate of Optical Excitons in FAPbI3 Nanocube Superlattices

Understanding the nature of the photoexcitation and ultrafast charge dynamics pathways in organic halide perovskite nanocubes and their aggregation into superlattices is key for potential applications as tunable light emitters, photon-harvesting materials, and light-amplification systems. In this work, we apply two-dimensional coherent electronic spectroscopy (2DES) to track in real time the forma

Long-Term Pattern of Psychotropic Medication Uses Among Swedish Parents of Children Diagnosed With Cancer

BACKGROUND: Parents experience a range of mental health disorders following their child's cancer diagnosis. It is thus essential to explore how the child's cancer diagnosis affects the dosage of psychotropic medication in both short- and long-term use, as well as potential disparities in utilization patterns between mothers and fathers.PATIENTS AND METHODS: Using Swedish registers, we identified a

Tuning Interactions in Correlated Electron Systems: From Two-Band Superconductivity to Quasi-1D Spin Chains

Neutron scattering techniques have been employed to investigate two key areas of condensed matter physics: superconductivity and quantum magnetism. The experimental studies span two distinct areas: two-band superconductors, where we explore the interplay between superconducting anisotropy and vortex structure, and quasi-one-dimensional (quasi-1D) spin chains, where we investigate the magnetic exci

Signal amplification in molecular sensing by imprinted polymers

In the field of sensing, the development of sensors with high sensitivity, accuracy, selectivity, sustainability, simplicity, and low cost remains a key focus. Over the past decades, optical and electrochemical sensors based on molecular imprinting techniques have garnered significant attention due to the above advantages. Molecular imprinting technology utilizes molecularly imprinted polymers (MI