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Fibrinogen genotypes and their impact on recurrence of venous thromboembolism and family history : A prospective population-based study

Venous thromboembolism (VTE) involves blood clot formation in veins, resulting in serious health issues. Fibrinogen, a crucial clotting protein, consists of three polypeptides encoded by the fibrinogen genes: alpha (FGA), beta (FGB) and gamma (FGG). We genotyped most common missense variants in the fibrinogen genes in relation to VTE, recurrence and family history in Malmö Thrombophilia Study, inc

Boosting Membrane Interactions and Antimicrobial Effects of Photocatalytic Titanium Dioxide Nanoparticles by Peptide Coating

Photocatalytic nanoparticles offer antimicrobial effects under illumination due to the formation of reactive oxygen species (ROS), capable of degrading bacterial membranes. ROS may, however, also degrade human cell membranes and trigger toxicity. Since antimicrobial peptides (AMPs) may display excellent selectivity between human cells and bacteria, these may offer opportunities to effectively “tar

Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices

Perovskite nanocrystal superlattices are being actively studied after reports have emerged on collective excitonic properties at cryogenic temperatures, where energetic disorder is minimized due to the frozen lattice vibrations. However, an important issue related to structural disorder of superlattices at low temperatures has received little attention to date. In this work, it is shown that CsPbB

Experimental X-ray Diffraction Data for "Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices"

Experimental X-ray diffraction data: -- temperature-dependent diffraction patterns (theta:2theta, rocking curves) for C18 and C8 CsPbBr3 nanocrystal superlattice samples;-- room temperature diffraction patterns (theta:2theta, rocking curves) for C6, C8, C10, C12, and C18 CsPbBr3 nanocrystal superlattices;in all files, first column is angle in degrees and the second column is intensity.

History of cellular grafting for central nervous system repair—A clinical perspective

As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in se

Health impact assessment of exposure to road traffic noise and air pollution according to pre- and post-densification scenarios in Helsingborg, Sweden

A prevalent solution to accommodate population growth due to urbanization is densification. However, this often pushes new residential housing closer to roads, increasing exposure to both noise and air pollution. The present study's aim was to estimate the health impacts of road traffic-related noise and air pollution for a low-income area (Drottninghög) in Helsingborg, Sweden, according to pre-de

Impact of Exposure to Hand-Held Vibrating Tools on Patient-Reported Outcome Measures after Open Carpal Tunnel Release : A Retrospective Cohort Study with Matched Controls

Objectives: Vibration exposure is a known risk factor for developing carpal tunnel syndrome (CTS), and insufficient outcomes for surgery for CTS have been reported after such exposure. We aim to investigate whether vibration exposure affects patient-reported outcomes following open carpal tunnel release. Methods: From a population surgically treated for CTS (n = 962), we identified patients who re

Does Fusobacterium in Colorectal Cancer Sites Originate From the Oral Cavity? A Pilot Study

Objectives: Fusobacterium can contribute to oral diseases, but also pose as a systemic risk factor. This genus, and especially F. nucleatum, can be found in colorectal cancer (CRC) tissue and is involved in multiple aspects of this type of cancer. Previous studies indicated a possible oral origin of these bacteria; however, stronger evidence is needed to reach a definitive conclusion. This pilot s

Targeted Investigational Treatment Analysis of Novel Anti-androgen (TITAN) study : ultralow prostate-specific antigen decline with apalutamide plus androgen-deprivation therapy

Objective: To assess the association between achievement of prostate-specific antigen (PSA) levels ≤0.2 ng/mL (henceforth ‘ultralow’) and clinical outcomes in patients in the ‘Targeted Investigational Treatment Analysis of Novel Anti-androgen’ (TITAN) study (ClinicalTrials.gov Identifier NCT02489318) with metastatic castration-sensitive prostate cancer (mCSPC). Patients and Methods: Patients in th

Evaluating Biparametric Versus Multiparametric Magnetic Resonance Imaging for Diagnosing Clinically Significant Prostate Cancer : An International, Paired, Noninferiority, Confirmatory Observer Study

Background and objective: Biparametric magnetic resonance imaging (bpMRI), excluding dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), is a potential replacement for multiparametric MRI (mpMRI) in diagnosing clinically significant prostate cancer (csPCa). An extensive international multireader multicase observer study was conducted to assess the noninferiority of bpMRI to mpMRI in

Genuine Multipartite Entanglement Detection with Imperfect Measurements : Concept and Experiment

Standard procedures for entanglement detection assume that experimenters can exactly implement specific quantum measurements. Here, we depart from such idealizations and investigate, in both theory and experiment, the detection of genuine multipartite entanglement when measurements are subject to small imperfections. For arbitrary qubits number n, we construct multipartite entanglement witnesses w

Colorimetric aptasensing of microcystin-LR using DNA-conjugated polydiacetylene

Polydiacetylene (PDA) holds promise as a versatile material for biosensing applications due to its unique optical properties and self-assembly capabilities. In this study, we developed a colorimetric detection biosensor system utilizing PDA and aptamer for the detection of microcystin-LR (MC-LR), a potent hepatotoxin found in cyanobacteria-contaminated environments. The biosensor was constructed b

Naphthalene Decomposition on Fe(110)─Adsorption, Dehydrogenation, Surface Carbon Formation and the Influence of Coadsorbed Oxygen

Tar is an undesirable byproduct of biomass gasification, which can be removed through catalytic reforming to syngas components. Iron is a promising, abundant alternative to highly active but toxic nickel catalysts. The results observed so far in catalytic studies with iron have been mixed. In this paper, the decomposition of naphthalene, a representative model compound of tar, was studied on the c

Few-Body Quantum Rings : An Exact Diagonalization Approach

This thesis investigates few-body quantum rings, particularly in the study of ultracold bosonic gases and nanowire quantum dots. These systems are investigated numerically using exact diagonalization methods. This dissertation contains five chapters which develop numerical and theoretical background for understanding the few-body calculations and analysis contained in the four included papers: Pap

Wigner-function formalism for the detection of single microwave pulses in a resonator-coupled double quantum dot

Semiconductor double quantum dots (DQD) coupled to superconducting microwave resonators offer a promising platform for the detection of single microwave photons. In previous works, the photodetection was studied for a monochromatic source of microwave photons. Here, we theoretically analyze the photodetection of single microwave pulses. The photodetection in this case can be seen as a nonlinear fi

Shaping opportunity spaces : the role of narratives in place leadership

This paper aims to identify micro-level processes shaping the narratives surrounding regional opportunity spaces. A process perspective is applied to examine how place leaders engage in shaping narratives to influence the perception of opportunity spaces. The empirical research is based on a comparative case study of four peripheral regions in Germany, comprising 92 interviews with regional stakeh

Continuous feedback protocols for cooling and trapping a quantum harmonic oscillator

Quantum technologies and experiments often require preparing systems in low-temperature states. Here we investigate cooling schemes using feedback protocols modeled with a quantum Fokker-Planck master equation (QFPME) recently derived by Annby-Andersson et al. [Phys. Rev. Lett. 129, 050401 (2022)0031-900710.1103/PhysRevLett.129.050401]. This equation describes systems under continuous weak measure

Comparison of renormalized interactions using one-dimensional few-body systems as a testbed

Even though the one-dimensional contact interaction requires no regularization, renormalization methods have been shown to improve the convergence of numerical calculations considerably. In this work, we compare and contrast these methods: "the running coupling constant"where the two-body ground-state energy is used as a renormalization condition, and two effective interaction approaches that incl

Refinement of Protein Extraction Protocols for Human Peripheral Nerve Tissue

Our aim was to establish an effective method for protein extraction from freshly frozen human peripheral nerves, determine the minimum amount required for consistent protein extraction outcomes, and assess which method produced the highest number of protein identities. Five extraction methods were compared using 8 M urea and Ripa buffer using either the Bullet Blender or Bioruptor. Out of the tota