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BackgroundWe introduce and apply an elegant, contrastive genetic-epidemiological design - Maternal Half-Sibling Families with Discordant Fathers - to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD).MethodUsing Swedish national registries, we identified 73 108 eligible pairs of reared together maternal half-siblings an

Recent contributions to the field of Resilience Engineering (RE) have added to the continuous development of new concepts and methodologies to improve resilience at different organisational levels. Part of these contributions has focused on training for adaptive capacity of individuals and teams to cope with changes and disturbances of work, since literature recognise that working tasks (at least

Introduction: The objective of this study was to describe the longitudinal cognitive outcome in Alzheimer’s disease (AD) and analyze factors that affect the outcome, including the impact of different cholinesterase inhibitors (ChEI). Methods: In an open, three-year, nonrandomized, prospective, multicenter study, 843 patients were treated with donepezil, rivastigmine, or galantamine in a routine cl

Values and opinions about what is valuable, are of centralimportance in risk and vulnerability analyses. Yet what is considered valuableis seldom explicitly established. The aim of this study is to explore what groupsof civil servants express as valuable and worth protecting when performing riskand vulnerability analyses in their organisations and to discuss the underlyingreasons for their stipula

There has been an increased focus in society on preparedness for emergency response in recent years. Today there is legislation that requires all Swedish authorities at the local, regional and national levels to prepare for emergency management and response. Since the task is rather new, most authorities are just beginning to address it. How the preparedness process should be designed and integrat

Objectives: Various outcomes of cholinesterase inhibitor (ChEI) therapy have been observed in Alzheimer’s disease (AD). It is not clear whether the duration of treatment, type of ChEI, or dose affect mortality. We aimed to investigate the association between ChEI therapy and patient survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study t

This paper includes a brief description of some closely related ongoing research activities aiming at learning from failures in order to improve the resilience of the Swedish railway system. One of these activities includes the development of a method aiming at assessing the capability for restoring the service of the railway system after strains affecting its technical, and often highly interdepe

Objectives: Long-term, placebo-controlled studies of cholinesterase inhibitors (ChEIs) in Alzheimer’s disease (AD) are not permitted for ethical reasons. Therefore, the advancement of knowledge on longitudinal outcomes in different domains warrants well-designed naturalistic studies. The aim of this study was to explore the 3-year effectiveness of rivastigmine treatment. Methods: The Swedish Alzhe

Introduction: Heterogeneity in cognitive outcomes and response to treatment has been described in Alzheimer’s disease (AD). Using the method of mixed models, higher resolution can be obtained to identify potential predictors of long-term outcomes. Aims: To analyse the impact of the APOE genotype, non-steroidal anti-inflammatory drug (NSAID) therapy and cholinesterase inhibitor treatment (ChEI) on

Background: The application of a bioresorbable calcium sulfate/hydroxyapatite (CaS/HA) ceramic at the interface of fenestrated screws and osteoporotic bone significantly enhances the immediate mechanical anchorage compared with non-augmented controls. However, the anchoring effectiveness of different screw augmentation techniques in spines with varying vertebral bone mineral density (BMD) remains

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif