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Neighborhood linking social capital as a predictor of psychiatric medication prescription in the elderly: A Swedish national cohort study.

Little is known about the association between neighborhood linking social capital and psychiatric medication in the elderly. The present study analyzes whether there is an association between linking social capital (a theoretical concept describing the amount of trust between individuals and societal institutions) and prescription of antipsychotics, anxiolytics, hypnotics/sedatives, antidepressant

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Aberrant soluble oligomers formed by the amyloid-β peptide (Aβ) are major pathogenic agents in the onset and progression of Alzheimer’s disease. A variety of biomolecules can influence the formation of these oligomers in the brain, although their mechanisms of action are still largely unknown. Here, we studied the effects on Aβ aggregation of DOPAL, a reactive catecholaldehyde intermediate of dopa

Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis

Aim: The study was designed to document the incidence of non-immune hydrops fetalis (NIHF) at birth and characterise associated outcomes and obstetric complications. Methods: Data on more than 1.9 million births were extracted from the Swedish Birth Register for 1997-2015. Pregnancies not affected by NIHF served as controls. National registers on mortality and hospitalisations provided follow-up i

Bone mineral as a drug-seeking moiety and a waste dump a Review

Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapat

Artificial intelligence together with mechanical imaging in mammography

Artificial intelligence (AI) applications are increasingly seeing use in breast imaging, particularly to assist in or automate the reading of mammograms. Another novel technique is mechanical imaging (MI) which estimates the relative stiffness of suspicious breast abnormalities by measuring the distribution of pressure on the compressed breast. This study investigates the feasibility of combining

Identification of on- And off-pathway oligomers in amyloid fibril formation

The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover,

Analys av sårbarhet med hjälp av nätverksmodeller

This report presents the research concerned with vulnerability analysis of technical infrastructure networks conducted in the research framework programme called FRIVA. The report reviews how network analysis has been used to analyse the vulnerability of systems that are possible to model as networks, such as technical infrastructure systems. In addition, it proposes how these methods can be devel

The Formation and Breakdown of Passive Film on Ni Alloys : in situ synchrotron studies

Corrosion results in huge annual costs and a large environmental footprint. The corrosion rate of some alloys can be made negligible by the presence of a spontaneously forming oxide film on the surface, a so-called passive film. Famous examples of alloys exhibiting passivity are stainless steels. However, in some demanding applications, stainless steel does not provide significant corrosion resist

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival

BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.AIM: To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.METHODS: Analyses were based on 82,701 women diagnosed with a first primary invasive BC incl

Glycodendrimers as Potential Multitalented Therapeutics in Alzheimer’s Disease

Finding successful therapies for the treatment of Alzheimer’s disease (AD) is one of the most challenging tasks existing for human health. Several drugs have been found and validated in preclinical studies with some success, but not with the desired breakthroughs in the following clinical development phases. AD causes multiple brain dysfunctions that can be described as a brain organ failure, resu

Individuell utveckling i grupp - sångundervisning tillsammans med och genom andra

Syftet med denna studie är att ur ett livsvärldsfenomenologiskt perspektiv dokumentera sång-ares upplevelse av sitt sångtekniska och musikaliska lärande i grupp och i förekommande fall sätta detta i relation till deras upplevelse av en enskild undervisning, samt att studera vilka faktorer som kan ha varit utslagsgivande för dessa upplevelser. Studien är kvalitativ och genomfördes som aktionsforsknTitle: Individual development in group - voice lessons together with and through others. The purpose of this study is to, from a life-world phenomenological point of view, document how singers experience their vocal technical and musical learning in group and in to relate this to their experience of a private lesson and to study what factors have been decisive for these experiences. This study is

Tillbaka till Ljubija – Upplevelser och erfarenheter hos återvändande bosnienmuslimer och bosnienkroater

Denna uppsats handlar om en grupp flyktingar som blivit utsatta för etnisk rensning av bosnienserbiska soldater under kriget i Ljubija, en stad i nordvästra Bosnien. Flyktingarna är bosnienmuslimer och bosnienkroater till sin etnicitet. Efter kriget har de återvänt till Ljubija som nu kontrolleras av bosnienserber. Syftet med uppsatsen är att försöka upptäcka och beskriva de problematiska sociala

Nätverk - en möjlighet att lära över organisationsgränserna?

Enligt vår empiri kan lärande uppstå även i nätverk som inte är skapade med grundtanke att lära. Nätverksplattformen är en viktig grund för att lärandet ska kunna utvecklas, vi ser dock lite annorlunda på tid och resurser då teorin säger att den är tidskrävande, medan vi menar motsatsen. Vi anser även att Nätverksplattformen behöver kompletteras. Här utgör bland annat struktur och rutiner en vikti

Kreativitet som konkurrensfördel

Syftet med uppsatsen är att utreda hur en organisation kan främja och tillvarata sin kreativa potential. För att finna svar på frågeställningen tog vi till en början till oss litteratur inom kreativitets-, organisations- och förändringsområdena och identifierade därigenom åtta viktiga, återkommande faktorer för att främja och tillvarata kreativitet. Dessa är vision, kontinuitet, delaktighet, mångf

The Cost Saving Potential of Standardization, -a study at a global packaging company

To introduce a standardized component assortment takes a lot of effort in order to make real cost savings. The rationalization effect itself is important, but perhaps even more important is to state the aim of the standardization efforts in a well-defined way. How can an organization assure that they are working in a proper way? How do they know that their efforts are being interpreted into the wh

The Effect of Family History of Diabetes and Middle Eastern Background on Abdominal Obesity is Modified by Gender: A Population based Cross-Sectional Study

Background: Abdominal obesity is on the increase worldwide and ethnic minority groups are at high risk. However, studies of the underlying causes are scarce. The aims of this study were to investigate the prevalence of abdominal obesity and to identify metabolic, lifestyle and socio-demographic risk factors associated with abdominal obesity in male and female residents of Malmö, a city in southern