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Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline
Metal oxide shell layers are promising candidates to improve the performance of metal nanoparticles (NPs) in various applications. However, despite a significant amount of experimental work on metal@metal oxide (M@MO) NPs, computational modeling is scarce, particularly on the sintering mechanism, which plays a crucial role in both the synthesis and performance of NPs. Here, we present atomic diffu
BACKGROUND: Sodium-glucose co-transporter (SGLT) inhibitors reduce cardiovascular outcomes including mortality in several populations; however, their effect on atrial fibrillation/flutter (AF) remains unclear. Our objective was to determine whether SGLT inhibitors reduce AF and whether a history of AF modifies the effect of SGLT inhibitors on the composite of heart failure hospitalization or cardi
Lack of tools for detailed, real-time observation of mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static transect positioned over rice fields outside a Tanzanian village. A quarter of a million in situ insect observations were classified, and several inse
The dynamic changes in composition in the near-surface region of a Pd75%Ag25%(100) single crystal were monitored using near-ambient pressure x-ray photoelectron spectroscopy (NAP-XPS) during CO oxidation under oxygen rich conditions at a total pressure of 1.1 mbar. Six CO oxidation temperature cycles were investigated at different heating rates and maximum temperatures of 450 °C or 600 °C. It was
Parasites exert a strong selection pressure on their hosts as manifested in behavioural antiparasite traits to reduce negative impacts on fitness. The numerous nest-dwelling ecto-parasites residing in avian nests make altricial birds excellent model-systems for investigating the relationship between parasites and their hosts. Here, we experimentally increased natural levels of hen fleas Ceratophyl
Background: Ambulatory blood pressure monitoring (ABPM) is increasingly recommended for clinical use, but more knowledge about the prevalence and variability in ABPM-derived phenotypes in the general population is needed. We describe these parameters in the community-based Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort. Methods: We examined 5881 men and women aged 50–64 with 24-hour ABPM r
Objectives: PMR is an inflammatory disease with prominent morning stiffness and muscular tenderness, usually diagnosed in primary health care (PHC). The objectives were to examine the validity of PMR diagnoses in PHC and to validate the use of classification criteria for PMR.Methods: Medical records for patients with a registered PMR diagnosis at two PHC facilities were reviewed. Patients were cla
Purpose: The study aims to explore how concept stores (theoretically) differ from other experience-based retail formats, and hence, how they (practically) contribute to a diversified retail store portfolio. Design/methodology/approach: Case study based on semi-structured, qualitative interviews with seven IKEA retail managers, three industry experts and 26 customers of IKEA concept stores in Londo
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist with clinical decisions about management of ccSVD, specifically white matter hyperinte
The dispersion scan (d-scan) technique has emerged as a simple-to-implement characterization method for ultrashort laser pulses. D-scan traces are intuitive to interpret and retrieval algorithms that are both fast and robust have been developed to obtain the spectral phase and the temporal pulse profile. Here, we shortly review the second harmonic generation d-scan technique, focusing predominantl
Deranged renal filtration of mid-sized (5-30 kDa) compared to smaller molecules (< 0.9 kDa) results in increased plasma levels of cystatin C (cysC) compared to creatinine resulting in a low eGFRcysC/eGFRcrea ratio. A ratio below 0.6 or 0.7, is termed shrunken pore syndrome (SPS), which in patient based studies is associated with mortality. Reference values for eGFRcysC/eGFRcrea ratio, the prevalen
The effect of instantaneous spectral diffusion (ISD) on gate operations in rare-earth-ion-doped crystals is an important question to answer for the future of rare-earth quantum computing. Here we present a microscopic modeling that highlights the stochastic nature of the phenomenon and use it to investigate ISD errors on single-qubit gate operations. Furthermore, we present a method to estimate th
We present two protocols for constructing quantum processor nodes in randomly doped rare-earth-ion crystals and analyze their properties. By varying the doping concentration and the accessible laser tunability, the processor nodes can contain anywhere from only a few tens to almost 1000 qubits. Furthermore, the average number of qubits each qubit can interact with, denoted by the connectivity, can
Precise control of the discharge in space and time is of great significance for better applications of discharge plasma. Here, we used a femtosecond laser filament to trigger and guide a high-voltage DC pulse discharge to achieve spatiotemporal control of the discharge plasma. In space, the discharge plasma is distributed strictly along the channel generated by the femtosecond laser filament. The
Children with cerebral palsy who are non-ambulant cannot stand or walk independently. In Sweden, daily static standing is part of standard care for these children even though it is time-consuming and costly, and while it may benefit the well-being of many children, it is inconvenient for others. A novel stander enables dynamic standing through walking movements. The aim of this study was to compar
Introduction The aim was to follow-up children, of parents with alcohol problems, who joined a group support programme in Malmö, Sweden from 1993–2000. Our intension was to investigate mental health and social well-being in these children over a long period of time.Method Two follow-ups were conducted, in 2003 and in 2018. In 2003 the follow-up, included a semi-structured interview and six self-
