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Active Posts in Deterministic Lateral Displacement Devices

Using electrically connected metal-coated posts in a deterministic lateral displacement (DLD) device and applying electric fields, electrokinetics is used to tune separations, significantly decrease the critical size for separation, and increase the dynamic range with switching times on the order of seconds. The strength of DLD stems from its binary behavior. To first approximation, particles move

Inequalities in the economic consequences of depression and anxiety in Europe : a systematic scoping review

BACKGROUND: Depression and anxiety are associated with adverse outcomes in educational achievements and economic performances. Moreover, the prevalence of these disorders is unequally distributed among different population subgroups. Our objective is to investigate whether the economic consequences of depression and anxiety differ between population subgroups of different gender, socioeconomic sta

Optimal power and efficiency of single quantum dot heat engines : Theory and experiment

Quantum dots (QDs) can serve as near perfect energy filters and are therefore of significant interest for the study of thermoelectric energy conversion close to thermodynamic efficiency limits. Indeed, recent experiments in [Nat. Nano. 13, 920 (2018)1748-338710.1038/s41565-018-0200-5] realized a QD heat engine with performance near these limits and in excellent agreement with theoretical predictio

Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics

Purpose: We previously showed that short-term intervention with barley kernel bread (BKB) improved glucose tolerance. However, glucose tolerance was not improved in a subset of individuals (non-responders) who were characterized by a low Prevotella/Bacteroides ratio. The purpose of the present study was to investigate if the baseline Prevotella/Bacteroides ratio can be used to stratify metabolic r

Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance : a genome-wide genetic interaction study

BACKGROUND: Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myeloma (MM). Yet much of genetic burden as well as functional links remain unexplained. We propose a workflow to expand the search for susceptibility loci with genome-wide interactio

Tumor necrosis factor inhibitors and cancer recurrence in Swedish patients with rheumatoid arthritis A nationwide population-based cohort study

Background: Use of tumor necrosis factor inhibitors (TNFi) in patients with a history of cancer remains a clinical dilemma. Objective: To investigate whether TNFi treatment in rheumatoid arthritis (RA) is associated with increased risk for cancer recurrence. Design: Population-based cohort study based on linkage of nationwide registers. Setting: Sweden. Participants: Patients with RA who started T

The hydraulic cavitation affected by nanoparticles in nanofluids

When liquids flow through a throttling element, the velocity increases and the pressure decreases. At this point, if the pressure is below the saturated vapor pressure of this liquid, the liquid will vaporize into small bubbles, causing hydraulic cavitation. In fact, a vaporization nucleus is another crucial condition for vaporizing, and particles contained in the liquid can also work as the vapor

Conceptualizing multiple drug use in patients with comorbidity and multimorbidity : proposal for standard definitions beyond the term polypharmacy

With older and aging populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple regular medications for their different diseases. Although the term “polypharmacy” has been applied to the use of multiple medications, there is no con

Self-healing dyes for super-resolution fluorescence microscopy

In recent years, optical microscopy techniques have emerged that allow optical imaging at unprecedented resolution beyond the diffraction limit. These techniques exploit photostabilizing buffers to enable photoswitching and/or the enhancement of fluorophore brightness and stability. A major drawback with the use of photostabilizing buffers, however, is that they cannot be used in live cell imaging

Thermoelectric Characterization of the Kondo Resonance in Nanowire Quantum Dots

We experimentally verify hitherto untested theoretical predictions about the thermoelectric properties of Kondo correlated quantum dots (QDs). The specific conditions required for this study are obtained by using QDs epitaxially grown in nanowires, combined with a recently developed method for controlling and measuring temperature differences at the nanoscale. This makes it possible to obtain data

Vitamin D intervention and bone : A randomized clinical trial in fair- and dark-skinned children at northern latitudes

Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D su

Precarious employment and mental health : the moderating role of household income and family type in Sweden

Background: This study investigated the moderating role of household disposable income and family type on the association between precarious employment (PE) and diagnosed mental disorders. Methods: This longitudinal study used register data from the Swedish Work, Illness, and Labour-market Participation (SWIP) cohort. The study population included all individuals aged 27–65 who were employed in 20

Molecular and seroepidemiology of SARS-CoV-2 among influenza-like illness and severe Acute respiratory illness cases in selected health facilities in Ethiopia

Background: SARS-CoV-2 remains globally circulating, yet post-pandemic comprehensive molecular, serological, and population-level immunity data from low-resource settings such as Ethiopia are limited. This study employed genomic surveillance with seroepidemiological assessment to characterize the epidemiology of SARS-CoV-2 among individuals presenting with influenza-like illness (ILI) and severe a

The outcome of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity

Background We investigate whether, in Swedish national registers, social and psychiatric outcomes for six major psychiatric and substance disorders - drug use disorder (DUD), alcohol use disorder (AUD), major depression (MD), bipolar disorder (BD), anxiety disorder (AD), and schizophrenia (SZ) - reflect the primary genetic risk for each disorder and the level of genetic heterogeneity. Methods We u

Transport and excitations in a negative-U quantum dot at the LaAlO3/SrTiO3 interface

In a solid-state host, attractive electron-electron interactions can lead to the formation of local electron pairs which play an important role in the understanding of prominent phenomena such as high T c superconductivity and the pseudogap phase. Recently, evidence of a paired ground state without superconductivity was demonstrated at the level of single electrons in quantum dots at the interface

Growth of InAs NWs with controlled morphology by CVD

We report on the growth of single crystal InAs NWs on Si/SiOx substrates by chemical vapor deposition (CVD). By adjusting growth parameters, the diameters, morphology, length and the proportion of superlattice ZB InAs NWs (NWs) can be controlled on a Si/SiOx substrate. Our work provides a low-cost route to grow and phase-engineer single crystal InAs NWs for a wide range of potential applications.

Full optoelectronic simulation of nanowire LEDs : Effects of temperature

Nanowires (NWs) have potential to enable new types of light-emitting diodes (LEDs), which also entail challenges for the development of improved full device simulation models. In this work we calculate the extraction efficiency and emission enhancement in NW array LEDs at different temperatures and couple the results to carrier transport simulations. Our results show that the extraction efficiency