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HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native alphalactalbumin (HLA) can be conveted to HAMLET by a two-step process including: 1) calcium ion removal in

The popularity of Open Source Software (OSS) has increased the interest in using it in safety critical applications. The aim of this study is to review research carried out on usage of open source code in development of safety-critical software and systems. We conducted a systematic mapping study through searches in library databases and manual identification of articles from open source conferenc

China is a mega-diversity country with abundant natural resources, and the richness of these resources is demonstrated to be relevant with the local people’s historical interactions between biophysical and sociocultural systems. If we are to maintain biodiversity and strike a balance between human well-being and ecosystem service, it is important to incorporate the local people and their tradition

The transport of neutrons in long beamlines at spallation neutron sources presents a unique challenge for Monte-Carlo transport calculations. This is due to the need to accurately model the deep-penetration of high-energy neutrons through meters of thick dense shields close to the source and at the same time to model the transport of low- energy neutrons across distances up to around 150 m in leng

Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin

Myoglobin is a heme-protein in the muscle of vertebrates with important functions in the oxygenation of tissues and as a regulator in nitric oxide signaling. Myoglobin from many species is also an important nutritional source of bioavailable iron. In this study, we have successfully produced human myoglobin in the leaves of Nicotiana benthamiana by transient expression using a viral vector deliver

Compton scattering is generally neglected in diffraction experiments because the incoherent radiation it generates does not give rise to interference effects and therefore is negligible at Bragg peaks. However, as the scattering volume is reduced, the difference between the Rayleigh (coherent) and Compton (incoherent) contributions at Bragg peaks diminishes and the incoherent part may become subst

Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high

Background: Embolic strokes of undetermined source comprise up to 20% of ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source international trial will compare the efficacy and safety of rivaroxaban,

With the advent of 5G technology, there is a growing need for advanced antennas that can support multifunctional apertures efficiently and with minimal interference, especially at millimeter-wave (mmWave) frequencies. The thesis addresses this challenge by designing, simulating, and evaluating a cloaked dipole antenna designed for 5G applications. The main concept of this work is a cloaking mechan

CLHEP is a project for developing a general C++ class library for high energy physics. This paper describes the motivation behind the project together with its current status. Also the future of the project is discussed.

Swedish has been generally assumed not to have any well-defined question intonation. However, with respect to Southern Swedish, Lindblad & Gårding (1973) present data showing final rises in polar (Y/N) questions. Gårding (1979) also assumes a broader and higher F0 range in Y/N questions than in statements, particularly on the final focussed word. The present study investigates the ex

Small acts and big effects Why should individuals act in a way that promotes Agenda 2030 goals and can we make them do so? Teachers: Mattias Gunnemyr (Practical philosophy) and Annika Wallin (Cognitive science) plus invited guests. The course gives a deeper understanding of collective harm cases and the inefficacy problem. Collective harm cases are situations where there will be bad consequences i

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2022-02/Course%20info_Small%20acts%20and%20big%20effects_2022.pdf - 2026-07-01