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BACKGROUND: Humans differ in the metabolism of the neurotoxicant methyl mercury (MeHg). This variation may be partially due to variation in genes encoding the transcription factor Nuclear factor E2-related factor 2 (NRF2) and its negative regulator Kelch-like ECH-Associated Protein 1 (KEAP1), which regulate glutathione and related transporter and antioxidant proteins that play a role in the metabo

Objective Studies indicate that the functional outcome evolves in the year after ischemic stroke onset. However, the traditional outcome measure in stroke trials is the modified Rankin Scale (mRS) at 90 days from onset. To determine mRS fluctuations in the first year after stroke, we examined data from 3 major stroke trials.MethodsIn a secondary analysis, we evaluated intrapatient mRS between 90 d

We investigate how selection of psychiatric cases by phenotypic criteria can alter the strength and specificity of their genetic risk by examining samples from national Swedish registries for five disorders: major depression (MD, N = 158,557), drug use disorder (DUD, N = 69,841), bipolar disorder (BD, N = 13,530)) ADHD (N = 54,996) and schizophrenia (N = 11,227)). We maximized the family genetic r

Background: Smartwatches are commonly capable to record a lead-I-like electrocardiogram (ECG) and perform a photoplethysmography (PPG)-based atrial fibrillation (AF) detection. Wearable technologies repeatedly face the challenge of frequent premature beats, particularly in target populations for screening of AF. Objective: To investigate the potential diagnostic benefit of six-lead ECG compared to

Vascular aging (VA) is a reflection of biological aging in general and subject to many influences during the life course. It involves all aspects of the cardiovascular system but is most visible in the age-related increased arterial stiffness of large elastic arteries, such as the aorta. It is possible to measure this process by pulse wave velocity (PWV). Several studies have now documented that i

It is predicted that novel nanometer-sized structures incorporating nanoparticles will have a considerable impact on our lives during the coming decades. Engineered nanoparticles are already found in a number of commercially available products. However, many applications of these nanoparticles have only reached the stage of promising ideas or research demonstrations. The number of nanoparticle-bas

There has recently been a considerable attention to the possible role of semiconductor nanowires for future device applications. To make this development feasible, precise control over the growth mechanism is required. In the Vapor-Liquid-Solid growth, the most common growth mechanism, gas phase precursors decompose in presence of catalytic particles and after supersaturating the particles, solid

This thesis concerns growth and characterization of gold-particle seeded nanowires of III-V semiconductor materials (III-V NWs). The nanowires were grown using metal-organic vapour phase epitaxy (MOVPE) and characterized by various microscopy techniques. In particular cross-sectional scanning tunnelling microscopy (XSTM) and cathodoluminescence microscopy (CL) were employed to investigate heterost

Throughout this thesis, samples of various materials with applications in energy converting devices have been prepared by focused ion beam machining and investigated by transmission electron microscopy. Energy converting devices can be solar cells or light emitting diodes, which turn light into electricity or vice versa. They can also be fuel cells or electrolyzer cells, which turn chemical energy

Low-dimensional III-V semiconductor nanoscale structures grown by epitaxial processes have emerged as a new class of materials with great promise for various device applications. This thesis describes explorations into the heteroepitaxial growth of III-V semiconductor materials in combination with other III-V materials and in combination with the commonly used Si material, in both thin layer and n

This thesis explores the possibility of using advanced device geometries and heterostructure engineering to manipulate, control, and study the electrical and optical properties of semiconductor nanowires. The first part of the thesis investigates the use of different gate-all-around architectures for creating new types of gate-controlled nanowire devices, primarily intended for fundamental studies