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The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to facilitate clinical research. Such integration of national registry data, which requires harmonization of the heterogeneous data sets into a unified view, is facilitated in the Europ

Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1

Background Robust clinical indices of etiologic heterogeneity for psychiatric disorders are rare. We investigate whether age at onset (AAO) reflects genetic heterogeneity, utilizing Genetic Risk Ratios (GRR) derived from Family Genetic Risk Scores (FGRS). Methods We examined, in individuals born in Sweden 1940-2003, whether AAO for five primary disorders - drug use disorder (DUD), alcohol use diso

BACKGROUND: SLE is associated with significant morbidity, especially in the case of renal involvement. Mitochondrial dysfunction plays a significant role in SLE and may be assessed by measuring mitochondrial DNA (mtDNA) and cytokines reflecting mitochondrial stress (mitokines). Circulating mtDNA is a promising biomarker in SLE and appears to be reduced in severe SLE. However, measuring circulating

Aims Previous studies on disparities in healthcare and outcomes have shown conflicting results. The aim of this study was to assess differences in baseline characteristics, management, and outcomes in myocardial infarction (MI) patients, by country of birth. Met hods a nd results In total, 194 259 MI patients (64% male, 15% foreign-born) from the nationwide SWEDEHEART (The Swedish Web-system for E

The rapid emergence of Generative Artificial Intelligence (GenAI) presents higher education with unprecedented opportunities to augment and enhance learning. As educators, learners, technologists and institutional leaders, we find ourselves navigating uncharted territory. How can we evaluate, integrate and govern these rapidly evolving technologies responsibly, so that they enrich rather than disp

Last week, six intrepid retail researchers from the Centre for Retail Research at Lund University travelled to London to observe the latest retail trends. Here, we summarise the most important trends and what the Swedish retail industry can learn from what is happening in London.

Expectations of what constitutes a positive customer experience have changed over time. Developments in technology and digital services have enabled new kinds of customer experience. As have new store formats and diversified retail offerings. Regardless of the form it has taken, customer experience has always been of paramount importance to retail managers. And it continues to be so. Over 50% of p

The new retail landscape is complex. New types of touchpoints and new store formats mean messy, non-linear customer journeys with multiple online and offline touchpoints. If we want to understand these journeys, and what value customers derive from new and innovative touchpoints, we must use methods that allow them to explain their own complex customer journeys in all their messy glory!

Introduction: Amphetamine use is an increasing problem, and studies suggest a connection between amphetamine use and cardiovascular and cerebrovascular pathology. However, few long-term studies examine amphetamine users' risk of cardiovascular and cerebrovascular pathology, in comparison to users of other drugs. In addition, in a criminal justice system, illicit drug use and psychiatric comorbidit

Background and aims: Environmental and genetic factors predispose to cardiovascular disease. Some first-generation immigrants have a higher cardiovascular risk in Sweden, while less is known about second-generation immigrants. We aimed to analyze the risk of acute myocardial infarction (AMI) among second-generation immigrants in Sweden. Methods: We included all individuals 18 years of age and olde

Attosecond pulses, produced through high-order harmonic generation in gases, have been successfully used for observing ultrafast, subfemtosecond electron dynamics in atoms, molecules and solid state systems. Today’s typical attosecond sources, however, are often impaired by their low repetition rate and the resulting insufficient statistics, especially when the number of detectable events per shot

Background and Non–HDL-C provides an estimate of lipid-associated risk and is a secondary treatment target after myocardial infarction Aims (MI). The aim was to study the relationship between non–HDL-C levels after MI and risk of adverse outcomes. Methods From the SWEDEHEART registry, 56 262 patients with MI were included. Outcomes were major adverse cardiovascular event (MACE: death, MI, and isch

BackgroundIn a previous phase II trial, intraperitoneal local anaesthetics shortened the time interval between surgery and adjuvant chemotherapy, an endpoint associated with improved survival in advanced ovarian cancer. Our objective was to test this in a phase III trial.MethodsA double-blind, phase III parallel superiority trial was conducted at two university hospitals in Sweden, within a public

PurposeWe studied the promising Alzheimer biomarker plasma tau phosphorylated at threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care to predict long-term neurological outcomes. We also compared it to total tau (t-tau), which has demonstrated predictive abilities of neurological outcome post-cardiac arrest.MethodsThis observational multicentre cohort study

A 2015 review of external examining in the UK assessed the effectiveness of the external examining system in safeguarding academic and quality standards in higher education. The development of the Professional Development Course for External Examiners was a key response to the recommendations from this review. This chapter contains an overview of the structure of the course, the key messages commu

This guide is designed to supplement the 2024 Advance HE Framework for Enhancing Assessment Framework in Higher Education, which is part of a series of frameworks developed to promote student success. The Enhancing Assessment Framework draws on the findings of an extensive literature review Impacts of higher education assessment and feedback policy and practice on students: a review of the literat