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Equalisation of alcohol participation among socioeconomic groups over time: an analysis based on the total differential approach and longitudinal data from Sweden

Background: Health inequality and its social determinants are well-studied, but the determinants of inequality of alcohol consumption are less well-investigated. Methods: The total differential approach of decomposition of changes in the concentration index of the probability of participation in alcohol consumption was applied to 8-year longitudinal data for Swedish women aged 28-76 in 1988/89. Re

Late Weichselian and early Holocene changes of vegetation, climate and sea level on the Skagi peninsula, northern Iceland

Popular Abstract in Swedish Denna avhandling är resultatet av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med undersökningen var att rekonstruera vegetations-, klimat- och havsnivåförändringar på Skagi-halvön, norra Island, under sen-Weichsel och tidig-Holocen. Nordatlantområdet genomgick en serie dramatiska klimatväxlingar i samband med övergången från den sSediment sequences from five lakes on the Skagi peninsula, northern Iceland, were subjected to mineral magnetic analysis, carbon analysis, pollen analysis, plant macrofossil analysis, diatom analysis, radiocarbon dating and tephra analysis in order to make detailed reconstructions of vegetation, climate and sea level during the Late Weichselian and Early Holocene. The main purpose was to investiga

Adipocyte phosphatases and the antilipolytic action of insulin

Popular Abstract in Swedish Min forskning handlar om hur nedbrytningen av fett i fettceller regleras genom att fosfat tas av och sätts fast på olika proteiner inuti fettcellerna. För att man skall förstå hur fettnedbrytning hänger ihop med att fosfat reagerar med proteiner är det bra att veta något om hur fettcellernas ämnesomsättning regleras. Energilagring och fettomsättning Människokroppen laAdipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. Protein kinase B (PKB) and phosphodiesterase 3B (PDE3B) are both phosphorylated and acti

Absorption and metabolism of orally fed arachidonic acid and linoleic acid in the rat.

[3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wa

The Politics of Natural Law : Agrarian Reform, Intra-Aristocratic Conflict, and Natural Jurisprudence in Denmark, c. 1750-1800

Popular science description The agrarian reforms of the 18th century were some of the most momentous historical events in Danish history. In the span of 30 years, half of all peasants went from living in a state of serfdom to owning and cultivating their own plots of land, free from the onerous ties of manorial dependence that they had toiled under for hundreds of years. In this pioneering dissert

Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain

The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemi

Heat-shock inhibits protein synthesis and eIF-2 activity in cultured cortical neurons

Stress, such as heat-shock, hypoxia and hypoglycemia, inhibits the initiation of protein synthesis. The effects of heat-shock on protein synthesis, eucaryotic initiation factor 2 (eIF-2) activity, protein kinase C (PKC), and casein kinase II (CKII) activities were studied in primary cortical neuronal cultures. In neurons exposed to heat-shock at 44°C for 20 min, protein synthesis is inhibited by m

Depression of Neuronal Protein Synthesis Initiation by Protein Tyrosine Kinase Inhibitors

Abstract— Growth factors stimulate cellular protein synthesis, but the intracellular signaling mechanisms that regulate initiation of mRNA translation in neurons have not been clarified. A rate‐limiting step in the initiation of protein synthesis is the formation of the ternary complex among GTP, eukaryotic initiation factor 2 (elF‐2), and the initiator tRNA. Here we report that genistein, a speci

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia : evidence against programmed cell death

The ultrastructural changes in the pyramidal neurons of the CA1 region of the hippocampus were studied 6 h, 24 h, 48 h, and 72 h following a transient 10 min period of cerebral ischemia induced by common carotid occlusion combined with hypotension. The pyramidal neurons showed delayed neuronal death (DND), i.e. at 24 h and 48 h postischemia few structural alterations were noted in the light micros

Acidosis enhances translocation of protein kinase C but not Ca2+/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia

Systemic hyperglycemia and hypercapnia severely aggravate ischemic brain damage when instituted prior to cerebral ischemia. An aberrant cell signaling following ischemia has been proposed to be involved in ischemic cell death, affecting protein kinase C (PKC) and the calcium calmodulin kinase II (CaMKII). Using a cardiac arrest model of global brain ischemia of 10 min duration, we investigated the

A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence

This protocol describes a model of cerebral ischemia based on organotypic hippocampal slice cultures and quantitative assessment of cell death by use of propidium iodide and image analysis. The cultures were made from rat hippocampal slices that were obtained at postnatal day 4-7 and allowed to develop for > 14 days in vitro. For induction of 'in vitro ischemia', the cultures were washed in glucos

Human Rights Due Diligence and the Issue of Conflict Minerals

År 2011 kom det första auktoritära ”soft law” dokumentet inom området företag och mänskliga rättigheter,”UN Guiding Principles on Business and Human rights”. I detta dokument åläggs företag ett ansvar att respektera mänskliga rättigheter genom att använda sig av en s.k."human rights due diligence" (HR DD). Denna ska bl.a. innehålla en "root cause analysis" för att överensstämmaIn 2011, the UN Guiding Principles (UNGPs) became the first authoritative international standard regarding the field of business and human rights. The document states a responsibility for companies to respect human rights. The operational principle of due diligence in the UNGPs is designed as a tool for companies to use in order to be able to respect human rights. However, if the due diligence is

Barnets bästa och rätten att komma till tals i FN:s konvention om barnets rättigheter och föräldrabalken

Den här uppsatsen behandlar principen om barnets bästa och rätten att komma till tals i FN:s konvention om barnets rättigheter (barnkonventionen) och föräldrabalken. Enligt 6 kap. 2 a § FB ska barnets bästa alltid komma i främsta rummet när frågor om vårdnad, boende och umgänge avgörs. I tredje stycket stadgas att vid bedömningen av barnets bästa ska hänsyn tas till barnets vilja med beaktande av This essay talks about the concept of the child’s best interests and the right of the child to be heard in the United Nations Convention on the Rights of the child and the Children Parents Code. According to the 6th chapter, section 2(a) in the Children Parents Code, the best interest of the child shall constitute the primary consideration in the determination of all questions concerning custody,

Får idrotten ha sin egen justis? - En utredning om gränserna för idrottares möjligheter att rättsligt överpröva idrottsinterna beslut i allmän domstol

Idrottsrörelsen har en stark tradition av självbestämmande, vilket även inbegriper idrottsintern tvistlösning. Denna tradition av självbestämmande har lett till att ytterst få tvister av idrottslig karaktär har prövats i allmän domstol. Syftet med denna uppsats är, mot bakgrund av detta och var och ens rätt till domstolsprövning enligt artikel 6 EKMR, att undersöka i vilken mån allmän domstol har

Beyond romantic love – an analysis of how the dilemma of closeness vs. autonomy is handled in relationship anarchy discourse

Sociologer hävdar ibland att kärlek i det senmoderna samhället genomgår en kris. En del av krisen handlar om en till synes svårlöst konflikt mellan närhet och självbestämmande. Människor vill å ena sidan stå varandra nära. Samtidigt kan närhet upplevas både kravfyllt och kvävande, men också riskabelt i den mån ett relationsval utestänger alternativa möjligheter. Frågan som ställer saken på sin speIn recent years, romantic love has been problematized and questioned by sociologists and activists. Part of this questioning comes from relationship anarchy, a phenomenon which can be described partly as a critical school of social philosophy, partly as a comparably small-sized social movement. Sociologists such as Beck and Beck-Gernsheim argue that romantic love suffers from a conflict between cl

Testing and Establishing of Material Models for Rubber Gaskets in Heat Exchangers using DIC

Testning och materialmodellering av gummipackningar i värmeväxlare För att en plattvärmeväxlare ska kunna fungera på ett effektivt sätt är det viktigt att ha packningar som klarar den höga belastningen. Detta examensarbete har inneburit att testa och anpassa nya materialmodeller för ett antal packningsmaterial för att förbättra utvecklingen i framtiden. Examensarbetet är gjort i samarbete med AlThe aim of this master's thesis is to establish material models for three rubber materials using macroscopic data collected using Digital Image Correlation, DIC. DIC is a non-contact optical technique for measuring strain and displacement in a material by tracking points on a material during the deformation process.\\ The rubber materials are tested in both uniaxial tension and compression, fr