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Influence of MK-801 on brain extracellular calcium and potassium activities in severe hypoglycemia

The purpose of the present study was to examine the effect of blockade of N-methyl-D-aspartate (NMDA) receptors on the depolarization associated with severe hypoglycemia, which is commonly preceded by one or a few transient depolarizations reminiscent of cortical spreading depression (CSD). In the cerebral cortices of rats [K+](e) and [Ca2+](e) were measured with ion-selective microelectrodes. NMD

Influence of Severe Hypoglycemia on Brain Extracellular Calcium and Potassium Activities, Energy, and Phospholipid Metabolism

Abstract: In the cerebral cortices of rats, during insulininduced hypoglycemia, changes in the concentrations of labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)] and glycolytic metabolites (lactate, pyruvate, and glucose) as well as phospholipids and free fatty acids (FFAs) were studied in relation to extracellular potassium and calcium activities. Changes in extracellular cal

Protein kinase C is translocated to cell membranes during cerebral ischemia

The subcellular distribution of PKC(α) and PKC(γ) was studied in homogenates of cerebral cortex from rats subjected to 10 and 15 min of ischemia and 15 min of ischemia followed by 1 h, 6 h, 24 h, 48 h, and 7 days of reperfusion. During ischemia no significant changes in the levels of PKC (α) were seen. During the first hour of reperfusion, a transient 2.5-fold (P < 0.05) increase in PKC(α) levels

The distribution of hypoglycemic brain damage

Rats were exposed to insulin-induced hypoglycemia resulting in periods of cerebral isoelectricity ranging from 10 to 60 min. After recovery with glucose, they were allowed to wake up and survive for 1 week. Control rats were recovered at the stage of EEG slowing. After sub-serial sectioning, the number and distribution of dying neurons was assessed in each brain region. Acid fuchsin was found to s

ANTISYMMETRIC ACTUATION INCREASES ACOUSTOPHORESIS PERFORMANCE

Antisymmetric, symmetric and standard actuation of acoustofluidic devices were compared in terms of focusability. By imaging the end part of an acoustophoresis separation channel while flowing fluorescent beads through it, we show that beads get more tightly focused by antisymmetric actuation than symmetric and standard actuation at a given electrical input power. This means that antisymmetric act

Inertia induced breakdown of acoustic sorting efficiency at high flow rates

We investigated the impact of inertial forces on acoustic sorting at high sample throughputs. Above a critical flow rate, we observed an unexpected inertia induced breakdown of the sorting efficiency that is not due to the wall induced lift force and was not previously described in the literature. We analyzed the effect experimentally and theoretically, providing an explanation to the phenomena, a

A Novel In Vivo Model for Multiplexed Analysis of Callosal Connections upon Cortical Damage

Brain damage is the major cause of permanent disability and it is particularly relevant in the elderly. While most studies focused on the immediate phase of neuronal loss upon injury, much less is known about the process of axonal regeneration after damage. The development of new refined preclinical models to investigate neuronal regeneration and the recovery of brain tissue upon injury is a major

Servicehundens betydelse för välbefinnandet hos personer med funktionsnedsättning. En litteraturstudie.

Bakgrund. Djur har länge använts inom vården i terapeutiskt syfte. Sjuksköterskan ska informera om olika vårdformer och bör således känna till hur servicehunden kan underlätta personers vardag. Syfte. Beskriva servicehundens betydelse för fysiskt, psykiskt och socialt välbefinnande hos personer med funktionsnedsättning. Metod. Litteraturstudie med nio artiklar, både kvantitativa och kvalitativa. R

How the New Product Development team should be formed and function given the radicalness of the innovation

Title: How the New Product Development team should be formed and function given the radicalness of the innovation Date of the seminar: 3rd of June, 2014. Course: Master Corporate Entrepreneurship and Innovation Internship and degree project (Master’s Thesis 15 ECTS) Authors: Jens Strinsjö and Paweł Polijaniuk Supervisor: Joakim Winborg Thesis purpose: The purpose of this Thesis is to examin

Kvalitet och läsbarhet för svenska hemsidor med information för vuxna med hörselnedsättning

Syfte: Utvärdera kvaliteten och läsbarheten för svenska hemsidor med information för vuxna med hörselnedsättning. Metod: De två sökorden hörselnedsättning och hörapparater, skrevs in i den mest använda sökmotorn i Sverige under januari 2016, Google. Därefter valdes de 20 första relevanta hemsidorna av varje sökord, det vill säga sammanlagt 40 hemsidor. Dubbletterna togs bort och totalt utvärderadeAim: Evaluating the quality and readability of Swedish websites with information for adults with hearing loss. Method: Two keywords hearing loss and hearing aids, were entered in Google (the most used search engine in Sweden, January 2016).The first 20 relevant websites were elected of each keyword, making a total of 40 websites. Removing duplicates resulted in 29 websites that were assessed. Eval

Nära och kära? Bevissvårigheter och reglering av närstående när kvinnor utsätts för våld i nära relationer

I denna uppsats behandlas några av de bevissvårigheter som finns vid våld mot kvinnor som begås i nära relationer, och som är en bidragande orsak till den bristande lagföringen av brotten. Syftet med uppsatsen är att granska särregleringen av närstående vittnen, samt det beslagsförbud av meddelanden mellan en misstänkt och en närstående som idag finns i svensk rätt. Våld mot kvinnor och våld i nThis paper discusses some of the evidence issues that exist in violence against women perpetrated in close relationships. This is a contributing factor to the lack of prosecution of these crimes. The purpose of this paper is to review the special regulation of related witnesses, as well as the seizure prohibition of written messages between a suspect and a related person that currently exists in S

Kunskapsöverföring mellan avdelningar - En branschöverskridande studie

Purpose: The purpose of this study is to increase the understanding of how factors related to knowledge in itself, the environment, the sender, the receiver, and the sender and receiver affect knowledge transfer between departments in different business sectors. We also intend to clarify differences between sectors and to map these differences. Methodology: As we have aimed to clarify what factor

Varför väljer celloelever att sluta i kulturskolans verksamhet? - en kvalitativ intervjustudie med tre celloelever från kulturskolans celloverksamhet

This study aims to, through qualitative interviews, highlight the voices of pupils who have dropped out of the culture school, to see what motivated them in the cello education at the culture school and what factors influenced them to stop taking lessons. The study was conducted through three individual interviews with two previous cello pupils and one current cello pupil, which for a period took