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Stem cells are key to human tissue maintenance. Because tissue maintenance allows us to live and reproduce, stem cell control is fundamental for animal life and evolution. A team of researchers set out to explore the origins of transcription factors at the core of the induction and the maintenance of stemnss. They focus on the conservation of the Sry-related box 2 (Sox2) and the octamer-binding tr
I min avhandling undersöker jag varierande placering av objekt till verb i svenskans historia. Primärt undersöks placering av nominala objekt visavi negerande adverbial, och sekundärt undersöks placering av nominala objekt visavi andra argument (subjekt och objekt) i huvudsatser. Materialet som ligger till grund för avhandlingen är texter från äldre och yngre fornsvenska (1225-1526), och huvudsaklThis thesis focuses on the distribution of objects in the history of Swedish. The primary focus of the thesis is the distribution of objects relative to negation, and the secondary focus is varying order of nominal arguments in Old Swedish (1225–1526).In Modern Swedish, objects may precede the negation, often referred to as Object Shift, OS, or precede a subject, often referred to as Long Object S
BACKGROUND: Covid-19 transmission via exhaled aerosol particles has been considered an important route for the spread of infection, especially during super-spreading events involving loud talking or singing. However, no study has previously linked measurements of viral aerosol emissions to transmission rates.METHODS: During Feb-Mar 2021, covid-19 cases that were close to symptom onset were visited
BACKGROUND AND OBJECTIVES: Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. CD36 is widely considered a platelet antigen (Nak a ) and anti-CD36 can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) in CD36-negative pregnant women. CD36 is used as a marker of differentiation in earl
Atmospheric oxygen (O2) concentrations likely remained below modern levels until the Silurian–Devonian, as indicated by several recent studies. Yet, the background redox state of early Paleozoic oceans remains poorly constrained, hampering our understanding of the relationship between early animal evolution and O2. Here, we present a multi-proxy analysis of redox conditions in the Caledonian forel
Horizontal gene transfer is one of the most important drivers of bacterial evolution. Transformation by uptake of extracellular DNA is traditionally not considered to be an effective mode of gene acquisition, simply because extracellular DNA is degraded in a matter of days when it is suspended in e.g. seawater. Recently the age span of stored DNA was increased to at least 2 Ma. Here, we show that
Our world is changing and cities and regions are increasingly understood not only as places, but also as vital hubs in national and global networks, through which people, capital, goods and services flow to ensure the functioning of society, as we know it. People and capital are increasingly concentrated in these hubs, which aside of positive effects on efficiency also is associated with challenge
Design is an activity aimed at solving an unsolved problem or improving an existing solution. In the area of societal safety, there are many activities that could be classified as design activities. For example when different actors are implementing measures to mitigate certain risk scenarios or when they are considering actions that could improve their capability to respond to various crises. We
Abstract in UndeterminedThe increasing effectiveness and efficiency of modern society is not only beneficial, but also liable for new or increased vulnerabilities. The seemingly ever-increasing complexity of modern society is in other words bringing new challenges for safety, security and sustainability. At the heart of these challenges lay an incremental increase in dependencies between sectors,
Popular Abstract in Swedish Att vatten är en otroligt viktig vätska för allt liv på jorden känner de flesta till; exempelvis består över hälften av människokroppen av vatten, och 70 procent av jordens yta är täckt av det. Att just denna till synes enkla kemikalie, vars molekyler består av två väteatomer och en syreatom, har en sådan unik betydelse är ingen slump, utan beror på att vatten har en raFluids composed of dipolar molecules are ubiquitous in nature, with water being the most prominent example. Due to their great importance and large complexity, a basic scientific understanding of the structure and thermodynamics of polar fluids is essential. In this thesis, simple polar model fluids are investigated with the aim of adding a bit to this understanding. In particular, the topics addr
Using the findings of incident investigations to improve patient safety management is well-established and mandatory under Swedish law. This study seeks to identify the mechanisms behind successful implementation of the recommendations of incident investigations.
Introduction: An increased production and use of carbon nanotubes (CNTs) is occurring worldwide. In parallel, a growing concern is emerging on the adverse effects the unintentional inhalation of CNTs can have on humans. There is currently a debate regarding which exposure metrics and measurement strategies are the most relevant to investigate workplace exposures to CNTs. This study investigated wo
Abstract in UndeterminedOur world is changing and cities and regions are increasingly understood not only asplaces, but also as vital hubs in national and global networks, through which people,capital, goods and services flow to ensure the functioning of society, as we know it. Peopleand capital are increasingly concentrated in these hubs, which aside of positive effects onefficiency also is assoc
Background: Stroke is one of the major causes of disability in the adult population and represents a heavy social and economic burden. Currently available therapeutic tools to support the recovery of impaired brain functions are quite limited. Animal studies have demonstrated that neuronal replacement and partial reconstruction of neural circuitry or modulation of the recovery process is possible
A growing body of evidence suggests that the deep oceans during the early Paleozoic Era were widely oxygen deficient, despite evidence for increased marine oxygenation during the Neoproterozoic. However, the temporal and geographic extents and dynamics of reducing marine conditions within these oceans are not well understood. Here, we investigate marine redox history during the Drumian through the
Objective This study investigated whether low-to-moderate exposure to welding fumes is associated with adverse effects on the cardiovascular system.Methods To test this, we performed a longitudinal analysis of 78 mild steel welders and 96 controls; these subjects were examined twice, six years apart (ie, timepoints 1 and 2). All subjects (male and non-smoking at recruitment) completed questionnair
