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For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. For example, cigarette smoking causes a variety of deadly diseases including lung cancer, hypertension, chronic obstructive pulmonary disease (COPD) and cardiovascular
Pure rotational coherent anti-Stokes Raman scattering (CARS) spectra of N2O was recorded in a series of temperature calibrated cell measurements in the region 295-796K. A theoretical rotational CARS code for N2O was implemented and temperature analysis was performed by fitting the modeled theoretical spectra to the experimental spectra. Excellent agreement between the experimental and modeled spec
A cotton skin and a waterproof but permeable Gore-Tex skin were designed for the thermal manikin “Tore” to simulate different sweating styles (the wet cotton skin inside and Gore-Tex skin outside to simulate the sweating style of thermal manikin “Walter”, and Gore-Tex skin inside with wet cotton skin outside to simulate the sweating style of thermal manikins “Newton”). The evaporative resistances
This article discusses the advantages of the the Coherence Based Genealogical Method (CBGM), not only as a tool for reconstructing the text of the New Testament, but also for surveying the history of readings and for explaining textual changes. The CBGM promises to detect readings, which have emerged several times independently in the textual tradition. The method is applied to selected examples i
A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction. Synaptic activity increases Aβ secretion, potentially inhibiting synapses, but also decreases intraneuronal Aβ, protecting synapses. We now show that levels of secreted Aβ fall with time in culture in neurons of AD-transgenic mice, but not wild-type mice. Moreover, the ability
In the light of technological changes, changes in business contexts, decreased number of IS students, changes in educational systems, etc., IS education commentators have urged the IS community to develop new and alternative IS curricula. In response to this, we present a model curriculum for a Bachelor of Science program in business information systems design (BISD 2007). The curriculum has a str
The aim of this work was to investigate the effect of storage in fat-free cheese on physical properties, microstructure and primary proteolysis up to 28 days of storage
Popular Abstract in Swedish För många cancerpatienter är strålbehandling ett viktigt behandlingsalternativ. En framgångsrik behandling kräver att den absorberade dosen till patienten kan ges med stor noggrannhet. Detta eftersom en liten avvikelse i absorberad dos kan påverka behandlingens resultat. Strålbehandling sker idag med avancerad teknik och utrustning där osäkerheterna i varje led i behandThis thesis presents a new verification concept, the virtual accelerator, for dose calculation algorithms used in treatment planning systems (TPSs) for external beam radiotherapy. The algorithm input data required to implement a treatment unit in the TPS are generated by Monte Carlo simulations as are the beam reference data needed for the subsequent evaluation of the dose calculation algorithm. T
As climate models can be used to reproduce historical climates, the outcomes can be used to put climate extremes in to a proper historical perspective. This also allows investigation of nonlinear properties of hydrologic processes (e. g. precipitation, runoff) to better understand regional hydrologic dynamics. To this end, the present study uses results from a so-called 'paleosimulation' (i.e. sim
A search for a narrow baryonic resonance decaying to K(s)(0)p or K-s(0)(p) over bar is carried out in deep inelastic ep scattering with the H1 detector at HERA. ss Such a resonance could be a strange pentaquark Theta(+), evidence for which has been reported by several experiments. The K(s)(0)p and K-s(0)(p) over bar invariant ss mass distributions presented here do not show any significant peak in
Neutral B meson oscillations in the B-s(0) - <(B-s(0))over bar>, and B-d(0) - <(B-d(0))over bar> systems were studied using a sample of about 4.0 million hadronic Z decays recorded by the DELPHI detector between 1992 and 2000. Events with a high transverse momentum lepton were removed and a sample of 770 k events with an inclusively reconstructed vertex was selected. The mass difference between th
Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n
Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particu
