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GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in

Background: We aimed to assess the risk of serious infections in patients with inflammatory bowel disease (IBD) exposed to different advanced therapies. Methods: We linked nationwide registers and compared rates of incident serious infections in patients with Crohn’s disease (CD) and ulcerative colitis (UC) exposed to medical therapies versus matched general population comparators during 2007-2023

Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or

Accurate, high-resolution global land use and land cover (LULC) mapping is crucial for environmental monitoring, but remains challenging when relying solely on multispectral data. Most existing global LULC mapping studies rely exclusively on multispectral observations, and even those that incorporate synthetic aperture radar (SAR) data often fail to fully exploit the information it provides. SAR p

BackgroundThe Job Demand–Control–Support (JD-C-S) model evaluates how psychosocial work factors affect health and performance. We examined how demographics, job title, and experience influence demand, control, and support among Ghanaian pharmacy staff.MethodsA cross-sectional survey of pharmacy personnel from Tamale and Sagnerigu was conducted using the JD-C-S questionnaire. Demand and control ite

Introduction Systemic inflammation is postulated to mediate heat stroke and heat-related organ injury, yet acute inflammatory responses among heat-stressed workers remains poorly understood. We aimed to describe neutrophil mobilisation and potential release of DNA during heat stress in multiple hot occupational settings and a controlled experimental setting. Methods Neutrophil:lymphocyte ratio (NL

Industrial Control Systems (ICS) have been compromised by cyber-attacks with the development of computer and network technologies over the past few decades. Intrusion Detection Systems (IDSs) play a significant role in ensuring information security, and the key mechanism is to identify various attacks in the network accurately. One common strategy when implementing an IDS is to use a machine-learn

Left ventricular (LV) stroke work (SW) is calculated from the pressure-volume (PV) loop. PV loops do not contain information on longitudinal and radial pumping, leaving their contributions to SW unknown. A conceptual framework is proposed to derive the longitudinal and radial contributions to SW, using ventricular force-length loops reflecting longitudinal and radial pumping. The aim of this study

BACKGROUND: Serial assessment of phosphorus is currently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, but its additional value versus a single measurement is uncertain. METHODS: We studied data from 17 414 HD patients in the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, and calculated the area under the curve (AUC) by multiplying the

Simultaneous measurements of particle size distribution (size/range 10-700 nm) inside an urban street canyon and a nearby urban background location in Copenhagen in May-November 2001 were used to separate the traffic source contribution in the street canyon from the background levels. The background concentrations are highly variable due to changing contributions from long-range transport and loca

There is an increasing recognition that, although the climate change and biodiversity crises are fundamentally connected, they have been primarily addressed independently and a more integrated global approach is essential to tackle these two global challenges. Nature-based Solutions (NbS) are hailed as a pathway for promoting synergies between the climate change and biodiversity agendas. There are

To assess (1) global longitudinal strain (GLS) by feature tracking cardiac magnetic resonance (CMR) in the sub-acute and chronic phases after ST-elevation infarction (STEMI) and compare to GLS in healthy controls, and (2) the evolution of GLS and regional longitudinal strain (RLS) over time, and their relationship to infarct location and size. Seventy-seven patients from the CHILL-MI-trial (NCT013

Thiazolidinediones are antidiabetic agents that decrease insulin resistance. Emerging evidence indicates that they present beneficial effects for the vasculature beyond glycemic control. The aim of this open-label observational study was to determine the effect of the thiazolidinedione rosiglitazone on novel cardiovascular risk factors, namely, lipoprotein(a) [Lp(a)], C-reactive protein (CRP), hom

OBJECTIVE—Glucagon-like peptide 1 (GLP-1) is an incretin that augments insulin secretion after meal intake and is developed for treatment of type 2 diabetes. As a novel therapeutic agent, characteristics of its β-cell effects are important to establish. Previously, β-cell effects of GLP-1 have been characterized in humans during graded intravenous infusions of glucose, whereas its effects after mo

Total and regional cerebral glucose metabolism (CMRgl) was measured by positron emission tomography with 2-(F-18) fluoro-2-deoxy-D-glucose ((18)FDG) in 20 term infants with hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. All infants had signs of perinatal distress, and 15 were severely acidotic at birth. Six infants developed mild HIE, twelve moderate HIE, and two severe HIE during

OBJECTIVES: To determine in a large prospective population-based cohort study relationships between different measures of body mass and incidence of severe knee and hip osteoarthritis (OA) defined as arthroplasty of knee or hip due to OA. MATERIALS AND METHODS: Body mass index (BMI), waist circumference, waist-hip ratio (WHR), weight, and percentage of body fat (BF%) was measured at baseline in 11

Progesterone (P-4) regulates many aspects of physiological functions via two nuclear P-4 receptors (PR), PRA and PRB, which are members of a structurally related nuclear hormone receptor superfamily that includes glucocorticoid receptors (Gk). The regulation and cellular distribution of PR protein isoforms have been extensively studied in reproductive tissues, but this is not the case in the lung.

BACKGROUND: Local pain at the site of an i.v. injection of propofol is a well-known problem, particularly in infants. This randomised investigator-blinded crossover study was designed to assess the effect of the i.v. bolus infusion rate on propofol-induced pain at the site of injection. METHODS: Thirty unpremedicated patients scheduled for ear-nose-throat or plastic surgery at Malmö University Hos

Introduction: The aim of this study was to investigate the 1986-1994 trend in obesity, overweight and sedentary leisure-time physical activity status, and the educational gradient in overweight and obesity in the city of Malmö, Sweden. Material/Methods: The public health surveys in Malmö 1986 and 1994 are cross-sectional studies. A total of 4,800 and 5,600 individuals aged 20–80 years were randoml

We tested the reliability and construct validity of the Compatible magnetic resonance imaging (MRI) scale for the evaluation of haemophilic knees and ankles and compared the diagnostic performance of MRI and plain film radiographs. Sagittal and coronal gradient-echo 1.5-T MR images of knees (n = 22) and ankles (n = 23) were obtained from boys (age range 4-16 years; mean 11 years) in two centres (T