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Our studies are focused on the revelation of WNT5A, a secreted glycoprotein. WNT5A belongs to the non-transforming class of WNTs, and upon binding to different receptors or co-receptor complexes, it elicits non-canonical (β-catenin-independent) signaling. WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. For example, in breast cancer loss of WNT5A protein is ass
Hand Surgery includes surgical and non-surgical treatment of conditions and injuries in the hand and the upper extremity. Hand Surgery is recognized as a clinical speciality in its own right in Sweden and units are located at the university hospitals. Our research covers a spectrum of conditions and injuries, extending from basic science up to clinical research with health science and health econo
Antioxidationsmedicin handlar om kroppens skydd mot oönskad oxidation. Oxidation är kemiska reaktioner som ständigt pågår mellan kroppens molekyler och luftens syre. För att kontrollera oxidationen så den inte blir för häftig tillverkar kroppen försvarsmolekyler, s.k. antioxidanter. Utan antioxidanterna hade vår kropp förmultnat på några månader, ungefär som en brasa som brinner upp, eller ett äppAntioxidation medicine describes how the body is protected against unwanted oxidation. ’Oxidation’ is a name for the chemical reactions between oxygen and the molecules of the body. Protection molecules, ’antioxidants’ are produced by the body to prevent the oxidation reactions from becoming violent. Without antioxidation control our bodies would quickly decay similar to a log fire or a decomposin
The laboratory consists of a XenX x-ray irradiator (XStrahl) for experimental radiobiology, with supporting equipment for cell culture applications, such as laminar flow cabinets, CO2 incubators, and a hypoxia workstation. The XenX unit is designed as a radiotherapy machine in miniature. It consists of a 225 kV x-ray source, mounted on a rotatable gantry allowing irradiation of specimens from all
Our research consists of several branches: 1) Blood coagulation. We perform basic research within the field of blood coagulation, thrombosis, arteriosclerosis and the complement system. Focus is on understanding fundamental mechanisms of the coagulation process which could be used in diagnostics or therapies. 2) Prostate cancer and noninvasive diagnostics. The objective is to satisfy the need for
Our laboratory is focused on understanding host-pathogen interactions, with emphasis on respiratory pathogens, and to use this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection. Our work focuses on both the factors used by bacteria to establish colonization and cause disease and how this is counteracted by host factors in human milk and by the
Our research is focused on the regulation of the complement system in health and disease. Complement is crucial part of innate immunity and thus protects host from infections and contributes to removal of dying cells. We study involvement of complement in pathology of rheumatic and inflammatory diseases as well as several types of cancer. Further, we investigate strategies developed by bacterial
Joint services are responsible for premises and facilities, caretaking and the receptions in the various buildings at LTH. Joint services operate in four of LTHs buildings. In other cases, Departmental Boards have the corresponding responsibilities.
The Swedish Stroke Register (Riksstroke) was founded in 1994. Riksstroke includes registration of acute stroke, with a follow up after 3 months and 1 year. The Stroke policy and quality register research group has several ongoing projects based on data from Riksstroke, and in many studies also using data record linkage to other national registers and data bases. The thesis of Teresa Ullberg expl
