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Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-specific roles of this enzyme, we established its conditional knockout using the Cre/loxP recombination system. Consistent with its role in cell death induction, deletion of caspase-8 in hepatocytes protected
The data-based verification of autonomous driving functionalities requires the detection of driving scenarios and driving styles. Driving scenarios define the tasks that the functionalities have to master, whereas the driving style has an impact on the traffic and thus the recorded traffic scenarios. In this thesis we consider two machine learning models which extract driving scenarios and driving
Genom lagen om anställningsskydd (LAS 1982:80) har arbetsgivaren i Sverige möjligheten att sluta avtal om provanställning. Provanställningen är en säregen anställningsform som enligt förarbetena har som syfte att ge arbetstagaren tid att visa sin arbetsförmåga för arbetsgivaren för att den senare skall kunna avgöra vid anställningens utgång ifall arbetstagaren är lämplig för jobbet. Provanställnin
In this thesis, the question of how to balance the right to reindeer herding against competing interests of land use in Sápmi in accordance with the indigenous rights of the Sami, will be examined. In order to answer this question other questions needs to be answered – What is the right to reindeer herding? Who is the holder of the right? Where can the right be exercised and finally, how can the rIn this thesis, the question of how to balance the right to reindeer herding against competing interests of land use in Sápmi in accordance with the indigenous rights of the Sami, will be examined. In order to answer this question other questions needs to be answered – What is the right to reindeer herding? Who is the holder of the right? Where can the right be exercised and finally, how can the r
Materials and Methods: Bark extracts of these plants (1 and 25 µg/mL) were added 3 hours before coincubating H9c2 cardiomyoblasts with Dox (0.5 and 1 µM) for 24 hours more. We measured cell mass and metabolic viability, mitochondrial transmembrane potential, superoxide anion content, and activity-like of caspase-3 and caspase-9 following treatment with the extracts and/or Dox. Also, selenium and v
Identity is often viewed as one of the most important concepts to help understand life in contemporary organizations among organizational scholars. For example, studies of identity among organizational members in roles such as e.g. manager, professional, consultant, and priest have provided valuable insights around managerial and professional work, motivation, change, leadership, control, and gendThis chapter examines if identity is as important as is often claimed, and as a consequence, when and why concerns of identity are triggered in working life, and we do so through a constructionist identity perspective. In the chapter, we argue that many people do not necessarily engage with their identities most of the time and explore why they do in certain kinds of jobs and in particular situati
