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Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling membrane proteins through the endolysosomal system. Here, we have generated a CHMP2B-mutated hum
Introduction: Detrended Fluctuation Analysis (DFA) has been used to investigate self-similarity in center of pressure (CoP) time series. For fractional gaussian noise (fGn) signals, the analysis returns a scaling exponent, DFA-α, whose value characterizes the temporal correlations as persistent, random, or anti- persistent. In the study of postural control, DFA has revealed two time scaling region
OBJECTIVES: Deep bone and joint infections (DBJI) are directly intertwined with health, demographic change towards an elderly population, and wellbeing.The elderly human population is more prone to acquire infections, and the consequences such as pain, reduced quality of life, morbidity, absence from work and premature retirement due to disability place significant burdens on already strained heal
Steady-state and picosecond time-resolved X-ray absorption spectroscopy is used to study the ground and lowest triplet states of [ReX(CO) 3 (bpy)] n+ , X = Etpy (n = 1), Cl, or Br (n = 0). We demonstrate that the transient spectra at both the Re L
This paper presents the assimilation of solar-induced chlorophyll fluorescence (SIF) into a terrestrial biosphere model to estimate the gross uptake of carbon through photosynthesis (GPP). We use the BETHY-SCOPE model to simulate both GPP and SIF using a process-based formulation, going beyond a simple linear scaling between the two. We then use satellite SIF data from the Orbiting Carbon Observat
Sera from 40 Swedish children diagnosed as having Type 1 (insulin-dependent) diabetes mellitus during a one year period along with 40 age and geographically matched control subjects were tested for antibodies to a Mr-64000 islet protein by immunoprecipitation of 35S-methionine-labelled rat islet amphiphilic proteins. Of the 40 diabetic patients, 29 (73%) were found to be positive whereas all 40 co
This article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingraiThis article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingrai
This paper examines how violent conflict affects the supply of education in one of the world’s poorest countries, Burkina Faso. We combine unique nationwide census data on all primary schools with geocoded records of Islamist violence to assess how local conflict exposure shapes school availability, staffing, and the mix of education provision. Using a staggered difference-in-differences design an
Given the important role of the land surface for climate, this study aims at (1) to evaluate the quality of the simulation of surface climate by the land-surface component of the EC-Earth3 ESM and (2) to assess the role of the coupling of the land surface with the atmosphere for the simulation of the surface climate in EC-Earth3. It is based on three simulations with different configurations of th
The processes responsible for the formation of Earth's most conspicuous diversity pattern, the latitudinal diversity gradient (LDG), remain unexplored for many clades in the Tree of Life. Here, we present a densely sampled and dated molecular phylogeny for the most speciose clade of damselflies worldwide (Odonata: Coenagrionoidea) and investigate the role of time, macroevolutionary processes, and
Agroforestry systems – combining trees with crops and/or livestock – are increasingly promoted as sustainable and climate-resilient land-use strategies. Despite their widespread presence in the Sahel, experimental data on their potential as carbon sinks are scarce. This study presents a full-year, high-frequency dataset of CO2 fluxes in a Sahelian agro-silvo-pastoral parkland dominated by Faidherb
Augustenborg is suburb city in Malmö south of Sweden. The climate is temperate with occasional snow during the winter. Open storm water is applied in Augustenborg since late 1990s and the storm water is disconnected from the combined sewer system in order to give the area a lift up value and to solve the flooding problems in basements after heavy rainfall events. The new open system consists of po
As climate change accelerates, rising sea levels and eroding shorelines are reshaping our coastal landscapes. Short-term fixes, such as beach nourishment and offshore breakwaters, are proving increasingly ineffective and costly. In nations like Sri Lanka, where tourism is a vital pillar of the economy and heavily dependent on beaches, these transient measures have become financially unsustainable.
Urban expansion is a defining feature of rapidly growing cities and has important implications for urban thermal behaviours, particularly in hot and semi-arid regions that are increasingly vulnerable to the effects of climate change. Tripoli, the capital of Libya, has experienced substantial urban growth over recent decades under conditions of weak planning and uneven development. Despite this, th
