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Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they pr
Background and aim: Telomere length (TL) is a key biomarker of cellular aging, with shorter telomeres associated with age-related diseases. Lifestyle interventions mitigating telomere shortening are essential for preventing such conditions. This study aimed to examine the effects of two weight loss dietary strategies, based on a moderately high-protein (MHP) diet and a low-fat (LF) diet on TL in i
Human telomerase reverse transcriptase (hTERT) is a critical factor in unlimited cell proliferation and immortalization, with numerous studies demonstrating that high expression of hTERT is a poor prognostic factor in various types of cancer. Ubiquitin-conjugating enzyme E2D 3 (UBE2D3) is a member of the E2 family, and participates in the ubiquitin proteasome pathway to regulate basic cellular act
OBJECTIVES: Esophageal cancer is a highly fatal malignant neoplasm, with 2 etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal cancer, esophageal squamous cell carcinoma (ESCC), with metformin therapy. This study aims to determine the association between metformin use and incident ESCC risk.METHODS: This
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis, but earlier tumor detection would improve survival. We aimed to develop and externally validate a risk prediction model based on exposure to readily available risk factors to identify high-risk individuals of ESCC.METHODS: Competing risk regression modeling was used to develop a risk prediction model. Individuals' ab
Plant phenology provides information on the seasonal dynamics of plants, and changes herein are important for understanding the impact of climate change and human management on the biosphere. Land surface phenology is the study of plant phenology across large spatial scales estimated by satellite observations. However, satellite observations (pixels) are often composed of a mixture of vegetation t
OBJECTIVE: Cone beam computed tomography (CBCT) can accurately assess erosive disease in the hands, wrists and feet in established rheumatoid arthritis (RA). The aim of this study was to compare CBCT with conventional radiography (CR) for the assessment of erosions in patients with early RA.METHODS: CBCT and CR of the hands, wrists and feet of 17 patients with treatment naive early RA were assesse
BACKGROUND: Attention Deficit Hyperactivity Disorder (ADHD) is a commonly occurring neurodevelopmental disorder associated with impairments in numerous aspects of functioning and quality of life. There is a growing recognition that brief and effective psychosocial interventions are needed for youth with ADHD.OBJECTIVE: The aim of this study was to assess the feasibility and preliminary effectivene
Introduction. The European Convention on Human Rights is but one of many human rights treaties binding upon European states. In particular at the level of the United Nations, numerous – general and specific – human rights treaties have been adopted, to which most Council of Europe member states adhere. This chapter examines how far the scopes of human rights at the UN and the Council of Europe lev
BackgroundComorbidity burden may affect the outcome following endovascular thrombectomy (EVT) for medium‐vessel occlusions. Since patients with high comorbidity burden are likely to be underrepresented in trials on EVT for medium‐vessel occlusions, observational data are needed to assess the benefit of EVT for these patients.MethodsWe conducted an observational study on all prestroke independent p
Purpose: The aim of this study was to evaluate risk factors for postoperative pain and nausea after open repair for primary ventral hernias. Method: A population-based registry study was conducted based on data assembled from the Swedish national ventral hernia repair register between January 2016 and December 2021and cross-matched with the Swedish perioperative register. Results: Altogether 2064
This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. Jawaharlal Nehru National Urban Renewal Mission, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holisti
This article investigates how social media can enable and constrain civil society organizations’ (CSOs) discharge of accountability. Based on a comparative analysis of the Instagram, Facebook, and Twitter (X) posts of the Swedish Red Cross during 1 year (N = 1014), we propose a framework of affordances that illustrate how platform features, practices, norms, and perceptions about audiences jointly
This paper investigates online gender-based violence (OGBV) in China using the perspectives of queer feminism and cyberfeminism. As a case study, it examines the cyberviolence against the “Pink Hair Girl” on Xiaohongshu (a popular Chinese social media platform) and the subsequent resistance by women. The study focuses on the following questions: How does the symbolic use of pink hair represent que
Excessive worry is common during adolescence and across psychiatric disorders. This study investigates whether: 1) internet-delivered cognitive behavioral therapy (ICBT) focused on exposure to uncertainty is effective in reducing excessive worry; 2) improvements in worry are associated with reductions in other psychiatric symptoms; and 3) changes in intolerance of uncertainty (IU) mediates worry o
Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program. Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving
OBJECTIVES: To reach agreement among experts on visual assessments of postural orientation errors (POEs) during the single-leg squat (SLS), and to use expert agreement assessments as ground truth for machine learning (ML) models to evaluate their ability to classify POEs.DESIGN: Methodological study with mixed-methods design.METHODS: POEs of the lower extremity and trunk were assessed from videos
This manuscript investigates the relationships among various performance metrics in a virtual reality (VR), namely frames per second (FPS), latency, batches, and the number of triangles (tris) and vertices (verts). The study aims to uncover correlations and directional associations between these metrics, shedding light on their impact on VR performance. The findings reveal a significant correlatio
Understanding the hydromechanical behavior of porous media such as sandstones is critical to various geoengineering applications such as geologic carbon storage, geothermal projects, oil and gas production and environmental remediation in aquifers. In these contexts, accurate quantification of the constitutive hydromechanical behavior of sandstones is necessary to predict reservoir responses. In t
