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Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness affecting 6-8 million people in Latin America. Reaching scholarly consensus on the host response to T. cruzi infection remains a significant challenge, primarily due to substantial heterogeneity in outcomes driven by both the choice of animal model and the infecting parasite's discrete typing unit (DTU). This var

What is the effect of punching holes at random in an infinite tensed membrane? When will the membrane still support tension? This problem was introduced by Connelly in connection with applications of rigidity theory to natural sciences. The answer clearly depends on the shapes and the distribution of the holes. We briefly outline a mathematical theory of tension based on graph rigidity theory and

The purpose of this narrative review is to provide an evidence-based update on management strategies for young adults with meniscal tears, based on two recent randomized controlled trials comparing a surgical vs. non-surgical treatment strategy for this patient group. The results from these trials suggests that exercise therapy is a viable treatment alternative for young adults with a meniscal tea

We describe the complete larval development of the pedunculated barnacle Capitulum mitella, using both light microscopy and scanning electron microscopy. This includes all six naupliar instars and the final cypris stage. Many previous accounts on the development of barnacle larvae suffer from a shortage in detail and habitually use terminologies that are either inconsistent or hard to compare with

This review paper provides a literature review of predictive methods and cybersecurity frameworks essential to safeguard Industry 4.0 manufacturing systems against cyber threats. The review focuses on two key areas: the prediction method and the data used for this prediction. These areas are critical for anticipating cyber threats and implementing effective countermeasures. They underscore the nee

Obesity may exacerbate colorectal cancer (CRC) prognosis, yet previous studies have shown inconsistent findings due to methodological limitations. In this nationwide cohort study, we investigated the association between body mass index (BMI) on CRC recurrence and mortality, while examining the influence of demographic, clinical, and socioeconomic characteristics. From the Danish Colorectal Cancer

Data acquisition and integration are vital aspects of circular industrial initiatives and help industries develop balanced coordination with other stakeholders and commitment to circular standards. Small and medium-sized enterprises hesitate to implement the necessary automation and information collection process because of high investment issues. The dairy industry does have a growing need for pr

Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for

Background. Adults with intellectual disability (ID) experience marked mental health inequities, yet population-wide estimates that capture both primary- and specialist-care diagnoses remain scarce. Methods. Using nationwide Swedish registries, including primary care, specialist, inpatient, prescription drug, criminal, and suspicion registers, we included all individuals born in Sweden between 195

As immersive technologies expand in education, a gap persists between teachers’ familiarity with virtual reality (VR) tools and effective pedagogical use. This study designed, implemented, and evaluated a 60-h VR Trainer Training Program using Educational Design Research (EDR) and the Taba-Tyler curriculum model. Sixteen teachers participated in a needs analysis, followed by 42 in-service teachers

Antimicrobial resistance (AMR) poses a major threat to global health, with limited surveillance data available from western sub-Saharan Africa. After reports of high rates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) in bloodstream infections at The Gambia’s sole tertiary hospital, we present follow-up data after enhancements in microbiology cap

Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind

In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data concerning the incidence of breast and gynecological cancers are similarly inconsistent. The aim of this study was to further investigate the incidence of these so-c

Introduction: Excessive worry is common during adolescence and across a range of psychiatric conditions. There is a growing evidence base for the efficacy of cognitive behaviour therapy (CBT) in reducing the frequency of excessive worrying as a primary outcome in the context of clinical trials of youth with generalized anxiety disorder, and as a secondary outcome in trials of CBT for youth with ob

Emerging evidence and clinical practice guidelines have highlighted that obesity, defined as a chronic disease characterised by excess or dysfunctional adipose tissue, may not be accurately measured or understood by solely relying on body mass index (BMI) which is a measure of size not functionality. An alternative to BMI, as proposed in the Canadian Adult Obesity Management Guideline, is the use

Immune thrombocytopenia (ITP) is characterized by the overproduction of antiplatelet autoantibodies. Although B-cell depletion therapies show promise in ITP, their high relapse rates suggest a potential de novo breakdown of tolerance during an early stage of B-cell development. Here, we investigated how central B-cell tolerance mechanisms affect autoantibody production in ITP. Paired single-cell R

Objective: To perform a systematic review and meta-analysis of randomised trials and observational studies assessing outcomes of different endovascular management approaches for the treatment of acute lower limb ischaemia (ALI) when adjusted for Rutherford classification. Data Sources: PubMed, Embase, Cochrane Library, and Web of Science. Review Methods: A literature search was performed in PubMed

Purpose Despite increased interest in opioid-free strategies, their clinical uptake remains limited. This study explores Swedish perioperative healthcare professional’s (HCPs) knowledge, attitudes, and practices regarding opioid and nonopioid analgesia across intraoperative and postoperative contexts. Design A national web-based survey was conducted among perioperative HCPs across Sweden between O