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Elevated levels of amyloid beta (Aβ) peptide, hyperphosphorylation of tau protein, and inflammation are pathological hallmarks in Alzheimer's disease (AD). Phosphodiesterase 7 (PDE7) regulates the inflammatory response through the cyclic adenosine monophosphate signaling cascade, and thus plays a central role in AD. The aim of this study was to evaluate the efficacy of an inhibitor of PDE7, named
Artikeln behandlar översiktigt arkitektur, porträttkonst, makt och historiebruk från Gustav Vasa till drottning Kristina. I den görs också utvikningar som relaterar den svenska utvecklingen inom området till den på kontinenten. En sammanfattning av övergången från medeltid till renässans till i Sverige ingår liksom en utblick på vad som sker inom arkitekturen i Skåne som vid tiden var danskt, samt
Using South African Families (SAF), a new database of settler genealogies, we provide the first comprehensive analysis of women’s cohort fertility in settler South Africa between 1700 and 1900. We find parity rates of approximately seven children per woman until a decline begins starting with women born in the 1850s. We date the start of South Africa’s fertility transition to cohorts born in the 1
BACKGROUND: Strong growth of interdisciplinary sciences might find exceptional example in academic health economics. We decided to observe the quantitative output in this science since the beginning of the twenty-first century.METHODS: Electronic search of the published literature was conducted in four different databases: one medical database-MEDLINE/PubMed, two general databases-Scopus/Elsevier
Lesch Alcoholism Typology (LAT) is one of the most widely used clinical typologies of alcohol addiction. Study tested whether introduction of LAT software in clinical practice leaded to improved outcomes and reduced costs. Retrospective matched-pairs case-control cost comparison study was conducted at the Regional Addiction Center of the University Clinic in Serbia involving 250 patients during th
AIMS: To support the Serbian Expert Board in setting up reimbursement for modern pharmacotherapeutic support, we compared a Serbian sample of alcohol-dependent patients with an Austrian sample, in order to detect differences that might inhibit the introduction of anti-craving medications in Serbia.METHODS: One hundred and twenty-seven (116 males) alcohol-dependent patients in Serbia and 136 in Aus
One reason why people avoid using social media to express their opinions is to avert social sanctions as proposed by the spiral of silence theory. We here elaborate on individual-level sensitivity to social rejection in relation to voicing political opinions on social media sites. Given the uncertainty about sharing political views in social media, and the fact that social acceptance, or rejection
Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 mo
Background: Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy and cognitive decline, but little data exist on the effects of APOE ε4 on tau. The objective of this prelim
Studies showing that large-scale public health interventions in early life have lasting consequences are still scarce and rarely disclose the mechanisms. In 1931–1946, the Swedish state reformed the childbirth institutional system that led to the openings of the new maternity wards and to the gradual decline in home deliveries assisted by midwives. Maternity wards offered improved conditions for a
Aims and objectives: To explore municipal healthcare employees' experiences of relationships with care recipients and colleagues. The specific research questions were when do the relationships enhance well-being, and what prerequisites are needed for such relationships to occur? Background: Employees in health and social care for older people often depict their work in negative terms, and they oft
This study explores the impact of living with Parkinson's disease (PD). Nineteen persons (11 women) aged 55-84 diagnosed with PD 3-27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: "Changed prerequisites for managing day-
Self-propagating, amyloidogenic mutant huntingtin (mHTT) aggregates may drive progression of Huntington's disease (HD). Here, we report the development of a FRET-based mHTT aggregate seeding (FRASE) assay that enables the quantification of mHTT seeding activity (HSA) in complex biosamples from HD patients and disease models. Application of the FRASE assay revealed HSA in brain homogenates of presy
Aim: This study compared follow-up protocols for paediatric celiac disease (CD) led by either paediatricians or dietitians at Swedish university hospitals. Methods: We followed 363 CD patients under 18 years at the university hospitals in Malmö (n = 140) and Lund (n = 79) between 2011 and 2013 and after they merged to become Skåne (n = 144) between 2014 and 2016. Both Lund and Malmö provided regul
Most of the models for solving the transportation Network Design Problem (NDP) often neglect equity goals that, assuming the societal function of transportation systems, should play an important role. The NDP should be addressed to solutions in which the outcomes of the design (costs and/or benefits) are distributed as fairly as possible among the potential users or class of users. In this paper,
Haemophilia A and B diagnosis and disease severity classification are determined on the basis of results from factor VIII (FVIII) and factor FIX (FIX) activity assays, respectively. These assays are also used for potency labelling, postinfusion monitoring of factor replacement products and testing for FVIII/FIX inhibitors. This review focuses on activated partial thromboplastin time (APTT)-based o
Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a central role in haemostasis, and plasma TAFI concentrations are heritable. Candidate gene studies have identified several variants within the gene encoding TAFI, CPB2, that explain part of the estimated heritability. Here, we describe an exploratory genome-wide association study to identify novel variants within and outside of the CPB2 loc
Migration usually consists of intermittent travel and stopovers, the latter being crucially important for individuals to recover and refuel to successfully complete migration. Quantifying how sickness behaviours influence stopovers is crucial for our understanding of migration ecology and how diseases spread. However, little is known about infections in songbirds, which constitute the majority of
