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BACKGROUND: Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on lipids investigated associations with perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), there are only a few studies regarding other PFAS, such as perfluorohexane sulfonic acid (PFHxS). The purpose of the current study is to i
Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A-G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medical and cosmetic uses. Besides binding to well-established receptors, an extended loop in the C-termin
Previously, intragenic CAMTA1 copy number variants (CNVs) have been shown to cause non-progressive, congenital ataxia with or without intellectual disability (OMIM#614756). However, ataxia, intellectual disability, and dysmorphic features were all incompletely penetrant, even within families. Here, we describe four patients with de novo nonsense, frameshift or missense CAMTA1 variants. All four pa
Introduction: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2 (COX-2), which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (1
Objective: The aim of this study was to explore the "Birth Attitude Profile Scale (BAPS)" in a selected sample of women with fear of birth. Another aim was to develop profiles of women according to their birth attitudes and levels of childbirth fear in relation to background characteristics.Methods: A secondary analysis of data collected in two different samples of women with fear of birth. Data w
We present spectroscopic determinations of the effective temperatures, surface gravities, and metallicities for 21 M dwarfs observed at high resolution (R ∼ 22,500) in the H band as part of the Sloan Digital Sky Survey (SDSS)-IV Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. The atmospheric parameters and metallicities are derived from spectral syntheses with 1D LTE plane-
In this study, we provide the results of radiological characterization of the RBMK-1500 graphite using modeling and nuclear spectrometry; we also introduce a method to identify neutron activation and surface contamination terms for the spent graphite waste. The simplified model of the reactor core created by programme package SCALE 6.2 for 4 × 4 fragment of the core was used for simulation of neut
Report from Working Group on Media and Narratives, Bratislava, 17th-20th of June 2019.
The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be
The diagnosis of tendon injury relies on clinical signs and diagnostic imaging but imaging is subjective and does not always correlate with clinical signs. A molecular marker would potentially offer a sensitive and specific diagnostic tool that could also provide objective assessment of healing for the comparison of different treatments. Cartilage Oligomeric Matrix Protein (COMP) has been used as
Objective: To assess how the prevalence of pain in a population-based sample of children and adolescents with cerebral palsy (CP) differ based on self- or proxy reporting. Methods: This cross-sectional registry study included 3783 children (58% boys), 1 to 18 years old, enrolled in the Swedish follow-up program for CP. Logistic regression was used to regress source of reporting (self or proxy) on
Copper from vehicles disc brakes is one main contributor of the total copper found in the environment. Therefore, the U.S. Environmental Protection Agency (EPA) and the automotive industries started the Copper-Free Brake Initiative. The pad friction material is essentially composed of a binder, fillers, reinforcing fibres and frictional additives. Copper and brass fibres are the most commonly used
The friction, wear and particle emission from an AlSiC MMC brake disc/non-asbestos organic brake pad system is studied using a pin-on-disc tribometer. The results show that this unconventional AlSiC MMC brake disc system presents friction performance as good as a conventional cast iron brake disc system. During braking, brake pad materials are transferred to the brake disc surface to form a protec
Background: The purpose of this work was to study usage of antibiotics, its possible determinants, and patterns of bacterial resistance in Swedish intensive care units (ICUs). Methods: Prospectively collected data on species and antibiotic resistance of clinical isolates and antibiotic consumption specific to each ICU in 1999 were analyzed together with answers to a questionnaire. Antibiotic usage
This paper reports on CFD simulations of in-cylinder flow and combustion in an open-bowl heavy duty diesel engine at high load. The focus of the study is to unravel the effect of swirl motion on the soot formation and on the late cycle soot oxidation. To incorporate detailed kinetic mechanism while maintaining a manageable computational time, Representative Interactive Flamelets (RIF) method is em
This study examined the longitudinal associations between non-suicidal self-injury (NSSI) in early adolescence and various positive and negative aspects of mental health in young adulthood. The participants were a cohort of regular school students (n = 1064) in grades 7–8 from a Swedish municipality. Nine hundred and ninety-one of these completed an 11-page questionnaire (T1: Mage = 13.7; 50.3% gi
Although teachers’ well-being and vocal health are affected by noise, research on classroom sound environment from the teachers’ perspective is scarce. This study investigated the relationship between teachers’ well-being and classroom acoustics. The possible influence of teachers’ age, experience, teaching grade and class size on the relationship was also investigated. In this study, well-being r
Decrease of saline lakes, which comprise 44% of all available lake water, is a major concern. It additionally accelerates the desertification process of the region. Thus, various countries have taken different actions in protecting their lake water levels. The aim of this paper is to assess different strategies directed to tackle the decreased lake water levels in Lake Urmia and the Aral Sea, whic
Epidermolysis bullosa simplex (EBS) is usually inherited as an autosomal dominant disease due to monoallelic gain-of-function mutations in KRT5 or KRT14. Although autosomal recessive forms of EBS have been associated with mutations in at least 10 genes, recessive EBS due to homozygous biallelic KRT5 mutations has not been reported previously; it has been hypothesized that it would result in prenat
