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An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model—Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)—which uses a genetic construct to increase DA synthesi
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-
Pebbles of millimeter sizes are abundant in protoplanetary discs around young stars. Chondrules inside primitive meteorites - formed by melting of dust aggregate pebbles or in impacts between planetesimals - have similar sizes. The role of pebble accretion for terrestrial planet formation is nevertheless unclear. Here, we present a model where inward-drifting pebbles feed the growth of terrestrial
Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2
This paper studies entrepreneurship ecosystem development in a context little discussed in the extant literature to date: Oman. Specifically, it focuses on business incubation (BI) initiatives as a policy tool for developing the local, regional, and national systems of supporting entrepreneurship and SME growth. Although BI’s are a popular policy measure for ecosystem development, spreading global
ABSTRACT: The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trials. A systematic search up to March 2019 was performed in Embase, PubMed, PsycIN
This Phase I study investigated the recommended Phase II dose (RP2D) of inotuzumab ozogamicin (InO), a CD22-directed antibody-drug conjugate, in pediatric patients with multiple-relapsed/refractory (R/R) CD22-positive acute lymphoblastic leukemia (ALL). Patients (≥1-<18 years) received three InO doses (Days 1, 8, 15) per course. Dose-escalation was based on dose-limiting toxicities (DLT) during Co
The aims of the present study are formulated to test theoretical assumptions of the incivility spiral presented by Andersson and Pearson (1999). The first aim is to investigate possible longitudinal outcomes of witnessed workplace incivility, in the form of instigated incivility and well-being. An additional aim is to explore whether witnessed workplace incivility is indirectly related to instigat
BACKGROUND: Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we hypothesize that biomechanical factors alone can explain changes in myocardial volume and chamber size in valve disease.METHODS: A validated model of the human vasculature and the f
Female labor force participation increased significantly during the 20thcentury, not least in Sweden. In this paper, we investigate the importance of economic, demographic and sociocultural factors in the initial increase and growth of female labor force participationover the course of industrializationusing county-level data and panel regressions.There were important spatial differences across co
The possibility of analysis by the detection of elastically scattered particles for carbon, nitrogen, oxygen and also hydrogen determination in the fine mode of aerosols has been investigated. The main objectives in this study have been to find suitable projectiles (protons or alpha particles) and projectile energy, in order to obtain separated peaks for the elements of interest and to achieve hig
Based on a novel dataset of about 1150 time series, this study provides monthly economic activity estimates for 28 countries during the Great Depression. Due to their high frequency, the indices reveal that steady growth was far from universal even in the second half of the 1920s. Monetary and financial instability, agricultural crises, and labor conflict continued to plague economies around the g
Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low penetration of antibodies to cerebrospinal fluid (CSF) and brain parenchyma, resulting in poor target engagement. We here utilized transcranial macroscopic imaging to noninvasively evaluate in vivo delivery pathways of CSF fluorescent tracers.
he requirement of flexibility in the modern industries demands robots that can be efficiently and quickly adapted to different tasks. A way to achieve such a flexible programming paradigm is to instruct robots with task goals and leave planning algorithms to deduct the correct sequence of actions to use in the specific context. A common approach is to connect the skills that realize a semantically
The fourth version of the Ariadne program for generating QCD cascades in the colour dipole approximation is presented. The underlying physics issues are discussed and a manual for using the program is given together with a few sample programs.The major changes from previous versions are the introduction of photon radiation from quarks and inclusion of interfaces to the LEPTO and PYTHIA programs.
We report on the use of a liquid crystalline host medium to align single-walled carbon nanotubes in an electric field using an in-plane electrode configuration. Electron microscopy reveals that the nanotubes orient in the field with a resulting increase in the DC conductivity in the field direction. Current versus voltage measurements on the composite show a nonlinear behavior, which was modelled
The concept of partially premixed combustion (PPC), applied to conventional diesel engines, has shown to yield high gross efficiencies and low emissions of oxides of nitrogen and soot. PPC emerged from the knowledge gained from homogeneous charge compression ignition (HCCI) research. To extend the load range and thus reduce cylinder pressure rise rates, the fuel is directly injected during the comThe concept of partially premixed combustion (PPC), applied to conventional diesel engines, has shown to yield high gross efficiencies and low emissions of oxides of nitrogen and soot. PPC emerged from the knowledge gained from homogeneous charge compression ignition (HCCI) research. To extend the load range and thus reduce cylinder pressure rise rates, the fuel is directly injected during the com
Portugal has a unitary system in which the central government transfers funds to lower government levels for their public functions. In 2007, Portugal introduced Ecological Fiscal Transfers (EFT), where municipalities receive transfers for hosting protected areas (PA). We study whether introducing EFT in Portugal incentivized municipalities to designate PA and has led to a decentralization of cons
Background: Breakthroughs in the treatment of preterm birth approximately 40 years ago have enabled a generation of preterm survivors to now reach mid-adulthood. Understanding their health sequelae is essential for guiding their long-term care. We did a study to examine preterm birth in relation to mortality into mid-adulthood. Methods: A national cohort study was done of all 4 296 814 singleton l
