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Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification addressing pathogenic mechanisms as well as clinical relevance. This European multicenter trial was initiated to develop a consensus of 2 existing classification schemes based on flowcytometric B-cell phenotyping and the clinical course. The clinical evaluation of 303 patients with the established diagnosis of

The Lysinibacillus sphaericus proteins Tpp49Aa1 and Cry48Aa1 can together act as a toxin toward the mosquito Culex quinquefasciatus and have potential use in biocontrol. Given that proteins with sequence homology to the individual proteins can have activity alone against other insect species, the structure of Tpp49Aa1 was solved in order to understand this protein more fully and inform the desig

Background: High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI).Purpose: To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults presenting to the emergency department (ED) with chest pain.Data Sources: EMBASE

ImportanceSyncope remains a diagnostic challenge despite advancements in testing and treatment. Cardiac syncope is an independent predictor of mortality and can be difficult to distinguish from other causes of transient loss of consciousness (TLOC).ObservationsThe cause of TLOC is often unclear, hospitalization criteria are ambiguous, diagnostic tests are frequently non-informative, and assessment

Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.

Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers.

Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Tw

Acrylamide, classified in 1994 by IARC as 'probably carcinogenic' to humans, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. The association between dietary acrylamide intake and epithelial ovarian cancer risk (EOC) has been previously studied in one case-control and three prospective cohort studies which obtained inconsistent results, and could not further examine histologic

The aims of this study were to investigate the association between smoking and incident type 2 diabetes, accounting for a large number of potential confounding factors, and to explore potential effect modifiers and intermediate factors.

OBJECTIVES: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. METHODS: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recrui

Here we examined the ability of human neural progenitors from the embryonic forebrain, expanded for up to a year in culture in the presence of growth factors, to respond to environmental signals provided by the developing rat brain. After survival times of up to more than a year after transplantation into the striatum, the hippocampus, and the subventricular zone, the cells were analyzed using hum

Activating mutations of the PIK3CA gene occur frequently in breast cancer, and inhibitors that are specific for phosphatidylinositol 3-kinase (PI3K) p110α, such as BYL719, are being investigated in clinical trials. In a search for correlates of sensitivity to p110α inhibition among PIK3CA-mutant breast cancer cell lines, we observed that sensitivity to BYL719 (as assessed by cell proliferation) wa

Kallelse Sida 1 av 2 Fakultetsstyrelsen KALLELSE Datum 2021-03-26 Kallelse fakultetsstyrelsen Härmed kallas ledamöterna i fakultetsstyrelsen till sammanträde Tid: Onsdag den 7 april, kl. 13.15 – 15.30 (obs tiden) Plats: Zoom-möte. Länk: https://lu-se.zoom.us/j/67739935193 Förhinder meddelas till constance.holmback@science.lu.se Dagordning: 1. Utseende av justeringsperson 2. Fastställande av dagord

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2021-04/Protokoll-fakultetsstyrelsen-2021-04-07.pdf - 2026-05-09

Annual Report 2024, Lund Social Science Methods Centre Hantera uppdragsutbildning EN PRAKTISK GUIDE FÖR SAMHÄLLSVETENSKAPLIGA FAKULTETEN Sida 1 av 16 Kansli S Emma Tullberg, projektledare Uppdragsutbildning Praktisk guide V 2025/2345 2025-09-09 Hantera uppdragsutbildning – en praktisk guide Denna guide riktar sig framför allt till dig som är administratör, lärare och ekonom inom Samhällsvetenskapl

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2025-09/Praktisk%20guide%20fo%CC%88r%20uppdragsutbildning%20vid%20Sfak.pdf - 2026-05-09

LUND UNIVERSITY CFE Conference Papers Series No. 8 ISBN 978-91-984146-0-8 ISSN: 1654-2185 ED ITED B Y : B A R B A R A TÖ R N Q U IST-PLE W A , N IK LA S B E R N SA N D , M A R C O LA R O SA In Search of transcultural m em ory in E urope N o. 8 In Search of Transcultural Memory in Europe EDITED BY: BARBARA TÖRNQUIST-PLEWA, NIKLAS BERNSAND, MARCO LA ROSA CENTRE FOR EUROPEAN STUDIES AT LUND UNIVERSIT

https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfecp8.pdf - 2026-05-09

1 STRATEGI- OCH KVALITETSDOKUMENT 2019 Strategi- och kvalitetsdokument INSTITUTIONEN FÖR PSYKOLOGI | 2019 Ett strategi- och kvalitetsdokument ger en ökad transparens, möjliggör förankring och skapar en tydlig riktning för styrnings-, planerings-, implementerings- och utvärderingsprocesser. Strategi- och kvalitetsdokumentet vid Institutionen för psykologi ligger i linje med och påverkas av motsvara

https://www.psy.lu.se/sites/psy.lu.se/files/strategi-_och_kvalitetsdokument_2019_0.pdf - 2026-05-09

Publications Publications, Janne Rinne April 19, 2022 1 List of publications Summary: 121 papers in peer-reviewed journals, 4 book chapters, 1 lecture material (and revised new edition), 2 articles in professional journals, numerous non-peer-reviewed publications (conference abstracts, reports, etc.) Publications in peer-reviewed journals 121. Artaxo, P., H.-C. Hansson, M.O. Andreae, J. Bäck, E. G

https://www.nateko.lu.se/sites/nateko.lu.se/files/2022-04/publication_rinne.pdf - 2026-05-09

Introduction Lund University International Master’s Programme in Environmental Sciences (LUMES) INDUSTRIAL ENVIRONMENTAL LAW OF KALININGRAD REGION, RUSSIA: COMPARISON WITH SWEDEN AND DENMARK AND WAYS OF IMPROVEMENT Student: Ioulia Vassilieva, Address: LUMES P.O. Box 170, Lund SE-221 00, Sweden E-mail: ioulia.vassilieva.486@student.lu.se Supervisor: Peter Pagh, Professor of Environmental Law, dr. j

https://www.lumes.lu.se/sites/lumes.lu.se/files/vassilieva_ioulia.pdf - 2026-05-09