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Formoterol administered by a dry-powder (DP) capsule inhaler was compared with a pressurized metered-dose inhaler (pMDI) with regard to bronchodilating and systemic effects. The study used a double-blind, crossover, double-dummy technique. Twelve patients with moderate reversible asthma in a stable phase were examined on two separate study days, and the inhalers were given in randomized order. Aft
After infection with Borrelia burgdorferi, humans and mice under certain conditions develop arthritis. Initiation of inflammation is dependent on the migration of innate immune cells to the site of infection, controlled by interactions of a variety of adhesion molecules. In this study, we used the newly synthesized compound S18407, which is a prodrug of the active drug S16197, to analyze the funct
We discuss the climatic and environmental changes during the last millennium in NE Europe based on a ca. 8-m long high-resolved and well-dated marine sediment record from the deepest basin of Gullmar Fjord (SW Sweden). According to the Pb-210- and C-14-datings, the record includes the period of the late Holocene characterised by anomalously cold summers and well-known as the Little Ice Age (LIA).
Abstract A fracture of the proximal interphalangeal (PIP) joint at the base of the middle phalanx is rare, but is a challenge to treat. Posttraumatic osteoarthritis is a known complication causing impaired hand function and disability. The aim of the present retrospective study was to evaluate characteristics and outcome of complex PIP joint fractures treated by the pins and rubbers traction syste
Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten
Training and exercises programmes are not independent activities, forming part of a larger, risk-based, process of disaster management preparedness. In order to have an impact on an individual's skills knowledge or behaviours, or to influence organizational learning or procedures, the programmes needs a cyclic and holistic approach. It should focus on clearly identified outcomes that are designed
In order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theoryIn order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theory
This work is primarily about the development, validation and application of computer simulation models for intrinsically disordered proteins, both in solution and in the presence of uniformly charged, ideal surfaces. The models in question are either coarse-grained or atomistic in nature, and their applications are dependent on the specific purpose of each study. Both, Metropolis Monte Carlo and m
Over the last couple of decades, the European Union has enacted several pieces of legislation to improve insight into its agencies and institutions. This trend has been particularly significant for the pharmaceutical industry, as documents submitted to the EMA in order to have medicinal products approved have been increasingly subjected to public access requirements. Most recently, the 2014 regul
How signal diversity evolves under stabilizing selection in a pheromone-based mate recognitionsystem is a conundrum. Female moths produce two major types of sex pheromones, i.e., long-chainacetates, alcohols and aldehydes (Type I) and polyenic hydrocarbons and epoxides (Type II), alongdifferent biosynthetic pathways. Little is known on how male pheromone receptor (PR) genes evolvedto perceive the
In August 2022, a new rule on remote property securing was introduced. The rule is found in Chapter 6 § 12 a of the Enforcement Code, granting the Police Authority the power to secure property for enforcement purposes. This can occur when police officers, in the course of their normal duties, come into contact with property they suspect can be seized. In such cases, the Police Authority can call t
The purpose of the study was to examine counselors experiences and challenges regarding the work with the child perspective within child and adolescent habilitation in relation to the obligation to report. The study was conducted through interviews with seven counselors from various habilitation clinics in Region Skåne. The results indicate that counselors have an advisory and supportive role towa
