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Tamoxifen (Tam) is widely used in chemotherapy of estrogen receptor-positive breast cancer. It inhibits proliferation and induces apoptosis of breast cancer cells by estrogen receptor-dependent modulation of gene expression, but recent reports have shown that Tam (especially at pharmacological concentrations) has also rapid nongenomic effects. Here we studied the mechanisms by which Tam exerts rap
Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolat
The first identification of a sex pheromone of a pine sawfly (Hymenoptera, Diprionidae) dates back almost thirty years. Since then, female-produced pheromones of over twenty diprionid species have been investigated by solvent extraction followed by separation and identification. However, no study has shown what the females actually release. Collection of airborne compounds using absorbtion on char
Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R-306 in factor Va. It is generally accepted that only free protein S is active and that complex formation with C4b-binding protein (C4BP) inhibits the APC-cofactor activity of protein S. However, the present study shows that protein S-C4BP expresses APC-cofactor activity and stimulate
OBJECTIVES This study was designed to investigate the loss of well-being, in terms of lift-years, overall and in patients randomized to metoprolol versus carvedilol in the Carvcdilol Or Metoprolol European Trial (COMET). BACKGROUND The ultimate objectives of treating patients with heart failure are to relieve suffering and prolong life. Although the effect of treatment on mortality is usually desc
Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged
We present ab initio calculations of the optical rotation of S-propylene oxide in both gas phase and solution using the coupled cluster methodology combined with a dielectric continuum description of the solvent. The coupled cluster calculations are performed using the CCS, CC2, CCSD and CC3 methods. None of the presented gas phase results are in accord with the experimental sign of the optical ro
In 1995 and 1996 a Swedish feed mill had problems due to a persistent contamination of Salmonella enterica spp. enterica serovar Senftenberg that was difficult to eliminate. Forty-eight strains isolated from the feed mill, together with unrelated strains included to evaluate the discriminatory power and reproducibility, were analysed by pulsed-field gel electrophoresis (PFGE). The source of contam
Populärvetenskaplig sammanfattning: Conodonter är mikrofossil av en grupp numera utdöda ryggsträngsdjur eller tidiga ryggradsdjur, conodontdjuren. De små fosfatiska tandliknande strukturerna finns i huvudsak bevarade i marina karbonatbergarter från sen kambrium till sen trias. Conodonter har varit föremål för vetenskapliga studier sedan mer än hundra år tillbaka i tiden och den som först beskrev dThis investigation examines the distribution of conodont elements in the Early to early Middle Ordovician Latorpian, Volkhovian, Kundan and Aserian stages of the Tamsalu drill core in central Estonia. Slightly more than 24, 600 conodont elements from 17 samples were examined, and the biostratigraphic results were compared to previous works on conodont biostratigraphy from localities in Estonia, Ru
Kurslitteratur – HT24 Livslångt lärande NEKA81 Marknaden – priser, konsumenter och företag Principles of Economics, Saylor Academy, 2012, tillgänglig från https://saylordotorg.github.io/text_principles-of-economics-v2.0/. En uppsättning videoföreläsningar, artiklar och texter tillgängliga i lärplattformen Canvas. Kompletterande material. NEKA82 Staten och marknaden Shapiro, D., Macdonald, D., Gree
https://www.ehl.lu.se/sites/ehl.lu.se/files/2024-05/Kurser-livsl%C3%A5ngt-l%C3%A4rande-HT24.pdf - 2026-07-22
Almost half of all divorced Swedes today are aged 60+ and many of them are, or have been, a part of a reconstituted family (Bildtgård & Öberg 2014). This means that the probability of having step-grandchildren increases in a life cycle perspective. For those who have never had neither children nor stepchildren, a sibling's or a friend's grandchild can have the same meaning as a step-grandchild
NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 37 v 47 - 2020. UNIVERSITETSGEMENSAMT Erik Renström blir rektor för Lunds universitet* Regeringen har utsett Erik Renström till rektor för Lunds universitet 2021 - 2026. Renström är läkare och professor i exp
https://www.cec.lu.se/sites/cec.lu.se/files/2020-11/LU-gemensamt%20Mejlutskick%20Nr%2037-2020-v47.pdf - 2026-07-22
LU-template English 16:9 Faculty of Science Lund university 1 We are united in our efforts to understand, explain and improve our world and the human condition. 2 The faculty in numbers 8 departments or other units 1 085 employees (995 full-time equivalents) 2 922 students (1 626 full-time equivalents) Bachelor’s programme with 12 specialisations (3 in English) The hospital physics programme 18 ma
https://www.science.lu.se/internal/sites/science.lu.se.internal/files/2023-04/faculty-of-science-2022.pptx - 2026-07-22
A measurement of the beauty production cross section in ep collisions at a centre-of-mass energy of 319 GeV is presented. The data were collected with the H1 detector at the HERA collider in the years 1999-2000. Events are selected by requiring the presence of jets and muons in the final state. Both the long lifetime and the large mass of b-flavoured hadrons are exploited to identify events contai
