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DNA replication relies on precise coordination between proteins, including the sliding clamp proliferating cell nuclear antigen (PCNA), which encircles DNA to interact with key players in replication and repair. While biochemical studies have demonstrated interactions between PCNA and DNA polymerases δ and ε during DNA synthesis, the functional role of the Pol ε–PCNA interaction in vivo, particula
BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M
Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)
This dissertation examines the construction of monumental synagogues in nineteenth-century Sweden as a means through which Jewish communities articulated public presence, negotiated belonging, and translated aspirations for civic inclusion into durable architectural form. Focusing on five purpose-built synagogues in Gothenburg (1855), Norrköping (1858), Stockholm (1870), Karlstad (1899), and Malmö
Protein tyrosine phosphatases (PTPs) are a family of enzymes that play important roles in regulating cellular signaling pathways. The activity of these enzymes is regulated by the motion of a catalytic loop that places a critical conserved aspartic acid side chain into the active site for acid–base catalysis upon loop closure. These enzymes also have a conserved phosphate-binding loop that is typi
How can different value chain actors mitigate threats or benefit from moments of volatility? This question has become essential as global value chains are restructuring, with policymakers and management scholars calling for increasing value chain resilience. Surveying geographers’ recent contributions, this paper develops a geographical political economy of value chain resilience, which helps expl
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
TOI-2015 is a known exoplanetary system around an M4 dwarf star, consisting of a transiting sub-Neptune planet in a 3.35-day orbital period, TOI-2015 b, accompanied by a non-transiting companion, TOI-2015 c. High-precision radial-velocity measurements were taken with the MAROON-X spectrograph, and high-precision photometric data were collected, primarily using the SPECULOOS, MUSCAT, TRAPPIST and L
People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.
Background: Whole Transcriptome Sequencing (WTS) is a comprehensive alternative to targeted panels for detecting gene fusions and splice variants. To integrate WTS into clinical diagnostics, we compared its performance against established fusion assays (Archer FusionPlex and TSO500 RNA). Methods: WTS was evaluated in an initial cohort of 64 FFPE tumor samples, and quality control (QC) thresholds w
Background: We aimed to determine corticosteroid (CS) use in paediatric inflammatory bowel disease (PIBD, < 18 years), which remains common despite recommendations for limited use and the emergence of steroid-sparing therapies. Methods: We conducted a study of all children in Sweden diagnosed with CD (n = 2460) or UC (n = 2470) in 2006–2022. Nationwide health registers provided annual individual-l
INTRODUCTION: Stroke is a leading cause of death and disability worldwide. Recurrent strokes are seven times more lethal than initial ones, with 54% leading to long-term disability. Substantial recurrent stroke risk disparities exist among ancestral groups. Notably, Africans face double the risk and higher fatality rates compared to Europeans. Although genetic studies, particularly GWAS, hold prom
In this chapter, I reflect on the use of sociologist Erving Goffman’s dramaturgical metaphor to understand the victim-offender mediation process. Using metaphors can both open unexpected, valuable views, as well as be limiting. Having entered a specific metaphoric realm means that we are able to perceive particular aspects and perspectives (as crucial) but not others. One benefit of the dramaturgi
In nature, bacteria usually exist as mixed-species biofilms, where they engage in a range of synergistic and antagonistic interactions that increase their resistance to environmental challenges. Biofilms are a major cause of persistent infections, and dispersal from initial foci can cause new infections at distal sites thus warranting further investigation. Studies of development and spatial inter
I dagens välfärdstjänster har synen på användaren i allt högre grad förskjutits från en passiv mottagare till en aktiv deltagare i värdeskapande. Denna förskjutning återspeglas i policyreformer, organisatoriska strategier och akademisk diskurs, vilka alla i ökande grad betonar användarorientering. Inom det teoretiska ramverket Public Service Logic (PSL) framställs användarorientering som ett sätt In today’s welfare services, how the user is viewed has increasingly been shifting away from a passive recipient towards an active participant in value creation. This shift is reflected in policy reforms, organisational strategies, and academic discourse, with all of these placing a growing emphasis on user orientation. Within the theoretical framework of Public Service Logic (PSL), user orientati
Managed Aquifer Recharge (MAR) ponds are widely used to enhance groundwater, but efficiency is limited by uncertain infiltration pathways, heterogeneous sediments, and surface clogging. Understanding infiltration responses to variable inflow and evolving subsurface conditions is essential for optimizing pond performance. This study applied an automated multielectrode Direct Current Resistivity and
