Filetype
Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent resistance to chemotherapy. We hypothesized that DA WT cells might undergo changes, such as acquiring a persistent tolerance to DNA damage and copy number aberrations (CNAs), which could eventually lead to their resista
'Daniel Hjorth and Chris Steyaert set out to advance the study of entrepreneurship by refocusing the lens of discovery from economics, management and marketing to other paradigmatic stances in social sciences and humanities like anthropology and literary studies. The result is a provocative collection of chapters that inspire the reader to consider and explore new ideas and research practice that
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif
Daniel Hjorth and Chris Steyaert make a unique contribution to management education. Their ability to illustrate complex ideas through theatre and visual media is outstanding and much appreciated by a wide audience. This book is no exception. Their insights into the nature of entrepreneurship are fresh and original. Their style of presentation is both rich and rewarding. This is a book to surprise
Background and aims: Few studies have tested the effect of a motivational telephone intervention from a gambling operator to clients with high-risk gambling practices. This study aimed to study subsequent limit setting, self-exclusions and gambling post-intervention, compared to controls. Methods: The study assessed a motivational, personalized telephone intervention by the state-owned Swedish gam
The presence of distant protoplanets may explain the observed gaps in the dust emission of protoplanetary disks. Here, we derive a novel analytical model to describe the temporal decay of the pebble flux through a protoplanetary disk as the result of radial drift. This has allowed us to investigate the growth and migration of distant protoplanets throughout the lifespan of the disk. We find that M
In the context of the current refugee crisis, there has been a revival of concern with territoriality, nationality, and identity throughout Europe. In response to this revival, Reiner Anselm develops a theological ethics of community and citizenship from a Protestant perspective. Concentrating on the controversies which have characterized German Protestantism, he analyzes how theologians have aime
Electric Road Systems (ERS) are effective charging infrastructures that allows electric vehicles to receive energy while driving. This energy is used both to propel the vehicle and to charge the battery. Sufficient deployment of ERS implies that charging opportunities become greatly increased, allowing for electric vehicles to have smaller batteries and easing some of the problems associated with
Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be involved in the progression of diabetes through impaired insulin secretion under glucolipotoxic stress. The underlying mechanism reveals the pathologic role of the hyperactivation of mechanistic target of rapamycin (mTOR), w
Blinks, the closing and opening of the eyelids, are used in a wide array of fields where human function and behavior are studied. In data from video-based eye trackers, blink rate and duration are often estimated from the pupil-size signal. However, blinks and their parameters can be estimated only indirectly from this signal, since it does not explicitly contain information about the eyelid posit
This article discusses the self-perceived integration of Swedes permanently residing in Portugal. The knowledge of how EU citizens, particularly Swedes, live and integrate into Portuguese society is limited. The conceptual framework on self-perceived integration takes its points of departure from the concepts of a sense of belonging to society and place, feelings of discomfort and coping tactics.
IMPORTANCE Moderate-grade adolescent idiopathic scoliosis (AIS) may be treated with full-time bracing. For patients who reject full-time bracing, the effects of alternative, conservative interventions are unknown. OBJECTIVE To determine whether self-mediated physical activity combined with either nighttime bracing (NB) or scoliosis-specific exercise (SSE) is superior to a control of physical activ
Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with
The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nanometre to millimetre range by combining small- and wide-angle X-ray scattering with full-field microtomography. The modular design of the beamline is optimized for easy switching between different experimental modalities. The beamline has a special focus o
Sport-related concussion (SRC) is a serious injury in youth team sports, including handball. While research on the prevention of SRC has made progress over the past 5 years, prevention strategies are lacking in handball. The aim was to explore and develop strategies focusing on information, rules and training that may prevent concussion in youth handball by incorporating knowledge from experts and
BACKGROUND: Partial nitritation-anammox (PNA) is a biological nitrogen removal process commonly used in wastewater treatment plants for the treatment of warm and nitrogen-rich sludge liquor from anaerobic digestion, often referred to as sidestream wastewater. In these systems, biofilms are frequently used to retain biomass with aerobic ammonia-oxidizing bacteria (AOB) and anammox bacteria, which t
Adaptation to different ecological niches is considered one of the main drivers of species diversification, also in cryptic species complexes, notwithstanding their morphological stasis. We here review all the published information on ecological differentiation within cryptic species complexes within the phylum Rotifera. We found 177 instances of cryptic species identified genetically, published i
