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BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored

OBJECTIVE: To develop a prognostic model to predict disease outcomes in individual patients with Parkinson disease (PD) and perform an external validation study in an independent cohort.METHODS: Model development was done in the Comorbidity and Aging in Rehabilitation Patients: The Influence on Activities (CARPA) cohort (Netherlands). External validation was performed using the Cambridgeshire Park

Objective: To calculate costs for the management of deep foot infections and to identify the most important factors related to treatment costs. Design: Costs for in-hospital care, surgery, investigations, antibacterials, visits to the foot-care team, orthopaedic appliances and topical treatment were calculated retrospectively from diagnosis until healing or death. Multiple regression analysis was

INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.METHODS: This was a register

This thesis has contributed to the methodological development in the field of assistive technology and has generated new knowledge about the effectiveness and the service delivery process when powered mobility devices are provided to adult first time users in a Nordic context. Some of the results have been used to investigate the relationship between the three key elements of Donabedian’s conceptu

Popular Abstract in Swedish Inom forskningsområdet biogeokemi studerar man hur naturens olika grundämnen, såsom kol, kväve, fosfor och kisel ändrar form och transporteras genom landskapet för att via bäckar och vattendrag till slut nå havet. Tillsammans beskriver dessa olika processer, som sker på olika tidsskalor, från sekunder till flera miljoner år, ett grundämnes kretslopp (eller biogeokemiskaSilicon is the next most abundant element in the Earth’s crust and its biogeochemical cycle is linked with that of carbon. Further, silicon is a beneficial nutrient for plants in terrestrial ecosystems and a key nutrient for diatoms in aquatic ecosystems. During the last decade the important role of terrestrial vegetation in controlling Si fluxes downstream aquatic environments, via incorporation

The aim of the study was to visualize design regulations of furniture by means of interactive technology based on earlier studies and practical examples. The usage of the visualized regulations was evaluated on two occasions: at the start when the first set of regulations was presented, and after six years of usage of all regulations. The visualized regulations were the result of a design process

Många städer runt om i världen står inför samma utmaningar när det gäller kvinnors förmåga att röra sig och känna sig trygga i offentliga utrymmen. För kvinnor innebär användningen av offentliga utrymmen rädsla för sexuellt våld och för att bli attackerade, vilket tvingar dem att alltid vara vaksamma och minskar deras livskvalitet. Genom historien har städer planerats av främst manliga planerare,Many cities around the world are facing the same challenges when it comes to the ability for women to move around and feel safe in public spaces. For women, using public spaces entails fear of sexual violence and of being attacked, which forces them to always be vigilant and reduces their quality of life. Throughout history, cities have consisted of mainly male planners, designers and government

Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were inclu

The aim of this study was to investigate patients’ experiences of living with peripheral arterial disease (PAD) and the influence on activities of daily living. Twenty-four patients with various degrees of PAD were interviewed. The transcribed texts were analysed using manifest and latent content analysis. Living with PAD meant carrying a hard-to-bear physical, social and emotional burden, and str

Identification of ectomycorrhizal (ECM) fungi is often achieved through comparisons of ribosomal DNA internal transcribed spacer (ITS) sequences with accessioned sequences deposited in public databases. A major problem encountered is that annotation of the sequences in these databases is not always complete or trustworthy. In order to overcome this deficiency, we report on UNITE, an open-access da

Hydropower is the dominant source of electricity in Sweden, constituting 45% of the national supply. While pivotal for decarbonization and climate goals, its environmental impact on freshwater biodiversity is concerning. In this case study of a hydropower plant in Helge River, Sweden, the aim was to find a flow suitable for trout (Salmo trutta) and salmon (Salmo salar) reproduction. A terrain mode

Popularized summary Nowadays, the growing prevalence of natural disasters is driving people to pay more and more attention to emergency management. Progress in catastrophe analysis capabilities based on Geographical Information System (GIS) may allow the needs of public participation to be considered. Synchronous data sharing between citizens and emergency workers could effectively promote the proScientific summary The increasing prevalence of natural disasters is driving people to pay more and more attention to emergency management. Progress in catastrophe analysis capabilities based on Geographical Information System (GIS) may allow the needs of public participation to be considered. Synchronous data sharing between citizens and emergency workers could effectively promote the process of