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Germline mutations in the breast and ovarian cancer susceptibility gene BRCA1 are responsible for the majority of cases involving hereditary breast and ovarian cancer. Whereas all truncating mutations are considered as functionally deleterious, most of the missense variants identified to date cannot be readily distinguished as either disease-associated mutations or benign polymorphisms. The C-term

Projectile fragmentation of a 750 MeV/nucleon U-238 beam was used to populate neutron-deficient nuclei around A similar to190. Isomeric states in Hg, Tl, Pb, Bi, and Po isotopes were identified and their lifetimes determined, with the ultimate aim of measuring their isomeric ratios to provide information on the spin population in such reactions.

User grouping based on geographic location in fifth generation (5G) New Radio (NR) systems has several applications that can significantly improve network performance, user experience, and service delivery. We demonstrate how Sounding Reference Signals channel fingerprints can be used for dynamic user grouping in a 5G NR commercial deployment based on outdoor positions and heading direction employ

Sinus tachycardia (ST) is ubiquitous, but its presence outside of normal physiological triggers in otherwise healthy individuals remains a commonly encountered phenomenon in medical practice. In many cases, ST can be readily explained by a current medical condition that precipitates an increase in the sinus rate, but ST at rest without physiological triggers may also represent a spectrum of normal

This theoretical exposition proposes the critique of exaggeration as the approach to any philosophy that deals with the so-called existential themes. It provides the example of exaggeration in thinking beyond being in contrast to the question of being without exaggeration. Finally, it proposes the critique of exaggeration as a philosophical attitude that resists the temptation to seriously engage

ZusammenfassungWir beschreiben 10 Empfehlungen für die Entwicklung szientometrischer Visualisierungenund richten uns dabei vor allem an Betreibende szientometrischer Dienste. Die Grundlagedazu bilden Nutzerstudien mit Forschenden verschiedener Disziplinen in Deutschland, welchein einen iterativen Softwareentwicklungsprozess zur Entwicklung einer szientometrischenVisualisierung im Projekt ROSI eingWe describe 10 recommendations for the development of scientometric visualisations and address primarily the operators of scientometric services. The basis for this are user studies with researchers from different disciplines in Germany, who were involved in an iterative software development process for the development of a scientometric visualisation in the ROSI project.

BACKGROUND: After preoperative chemoradiotherapy (CRT) for rectal cancer, clinically undetectable residual tumour deposits or pathologic lymph nodes may remain in the mesorectum.AIM: The aim of this study was to report histopathological effects of CRT and factors affecting outcome in a uniformly treated series of locally advanced rectal cancer (LARC) patients.METHODS: Between 2004 and 2008, 107 pa

BACKGROUND: In the Netherlands, surgery for peritoneal metastases of colorectal cancer (PMCRC) is centralised, whereas PMCRC is diagnosed in all hospitals. This study assessed whether hospital of diagnosis affects treatment selection and overall survival (OS).METHODS: Between 2005 and 2015, all patients with synchronous PMCRC without systemic metastases were selected from the Netherlands Cancer Re

BACKGROUND: Multi-atlas segmentation, a popular technique implemented in the Automated Segmentation of Hippocampal Subfields (ASHS) software, utilizes multiple expert-labelled images ("atlases") to delineate medial temporal lobe substructures. This multi-atlas method is increasingly being employed in early Alzheimer's disease (AD) research, it is therefore becoming important to know how the constr

Viljan att skydda växter och djur får ibland orimliga effekter. Det skriver flera företrädare för Moderaternas arbetsgrupp för en kommande miljöpolitik på DN debatt.Farlig polariseringDe tar bland annat upp viktiga frågor om ”människans plats i naturen”. Men konflikten mellan utveckling och miljö är en återkommande missuppfattning. Frågan om naturvården främst bör utgå från människans eller nature

Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10×10

Popular Abstract in Swedish Är narkomaners personlighet relaterad till den drog som de valt att använda och föredrar? Detta undersöktes i en grupp om 128 tunga narkotikamissbrukare varav 37 var kvinnor och 91 män. De tre droger det gällde var heroin, som användes av 30 kvinnor och 52 män, amfetamin (7 kvinnor och 32 män) och hasch (7 män). Narkomanernas personlighet bestämdes med hjälp av två percThe topic dealt with in this thesis is whether, as Wieder and Kaplan (1969) suggest, the personality of drug addicts is related to their particular drug of choice. The subjects were 128 heavy drug addicts, 37 women and 91 men, each of them selected for the fact of there being one basic drug he/she abused. The drug of choice was either heroin (30 women, 52 men), amphetamine (7 women, 32 men) or can

We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were

BACKGROUND: In Phase II/III trials, administration of quadrivalent human papillomavirus (HPV) (types 6/11/16/18) L1 virus-like-particle vaccine was highly effective in preventing HPV6/11/16/18-related cervical intraepithelial neoplasia and non-invasive cervical cancer in women aged 16-26 years who were naïve to these HPV types at enrollment. However, the makeup and extent of catch-up vaccination p

Popular Abstract in Swedish Något tillspetsat förefaller varje kommun driva utvecklingsarbete inriktat på verksamhetsmått. Är så inte fallet är ansvariga snabba att betona att verksamhetsmått är viktigt och att de precis har beslutat om ett större måttprojekt. Denna bok ger en bild av i vilken omfattning fyra gatukontor utformar och använder verksamhetsmått. Boken innehåller också beskrivningar ocThe purpose of this study is to develop a frame of reference within which formal control system performance measures can be described and their design and use can be analyzed for control systems in municipalities. From a cybernetic control approach measures are used as instruments to plan and gain feedback from employee actions, and adjust them to the internal and external environment of which the

The gamma decay of the 12(+) yrast trap in Fe-52 has been measured for the first time. The two E4 gamma-branches to the 8(+) states are hindered with respect to other B(E4) reduced transition probabilities measured in the f(7/2) shell. The interpretation of the data is given in the full pf shell model framework, comparing the results obtained with different residual interactions. It is shown that

A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based

One-nucleon removal reactions at relativistic energies have been used as a spectroscopic tool for obtaining information about the ground state of neutron-rich oxygen isotopes. Using the FRS at GSI, the longitudinal momentum distributions of the emerging fragments after breakup were measured along with the one-nucleon removal cross-sections. The relative contributions of the remaining fragments in