Filetype
Past, present, and possible future changes in the Baltic Sea acid-base and oxygen balances were studied using different numerical experiments and a catchment-sea model system in several scenarios including business as usual, medium scenario, and the Baltic Sea Action Plan. New CO2 partial pressure data provided guidance for improving the marine biogeochemical model. Continuous CO2 and nutrient mea
Aim: To evaluate the results of ventral intermediate (Vim) thalamic deep brain stimulation (DBS) in patients with tremor predominant Parkinson's disease (PD) at 6 years post surgery. Methods: This was a prolonged follow-up study of 38 patients from eight centres who participated in a multicentre study, the 1 year results of which have been published previously. Total scores as well as scores for i
The exchange of carbohydrates and mineral nutrients in the arbuscular mycorrhizal symbiosis must be controlled by both partners in order to sustain an evolutionarily stable mutualism. Plants down-regulate their carbon flow to the fungus when nutrient levels are sufficient, while the mechanism controlling fungal nutrient transfer is unknown. Here we show that the fungus accumulates nutrients when c
Popular Abstract in Swedish De flesta cancerpatienter dör på grund av spridning av tumörceller till olika organ. Invasiv och metastaserande cancer svarar ofta inte på behandling och blir då i många fall dödlig. Leukemi är en elakartad sjukdom av blodceller, som påverkar blod-producerande organ. Den höga förekomsten av leukemi förekommer i äldre befolkningen och hos barn. Leukemi återfall och resiThe majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia
Ecological regime shifts typically result in abrupt changes in ecosystem structure through several trophic levels, which leads to rapid ecosystem reconfiguration between regimes. An interesting aspect of the impact of regime shift is that alternative regimes may induce distinct shifts in energy pathways; these have been less tested than structural changes. This paper addresses this by using stable
Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. Although several different cell types have been used in clinical trials, with the recent findings of somatic cell nuclear tr
Populations that undergo a process of rapid evolution present excellent opportunities to investigate the mechanisms driving or restraining adaptive divergence. The genetic variance-covariance matrix (G) is often considered to constrain adaptation but little is known about its potential to evolve during phenotypic divergence. We compared the G-matrices of ancestral and recently established ecotype
The large quantity of material of Hieracium sectt. Hieracium, Vulgata, Bifida and Oreadea collected during the recently completed floristic inventory of the northeastern most Swedish province of Norrbotten has been revised. The number of species known from this previously badly under-collected province hereby increased from 27 to 64, and seven species new to science were revealed. A diagnostic key
The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh pathogenic LRRK2 mutation causing monogenic Parkinson's disease (PD). So far, only two families worldwide have been identified with this mutation. By screening DNA from seven brains of PD patients, we found one individual with seemingly sporadic PD and LRRK2 p.N1437H mutation. Clinically, the patien
The aim of this paper is to provide insights into, and perspectives on, the transformation of mindsets for logisticians. We argue that by exploring paradoxes inherent in the efficiency-focused paradigm of today, a strategic mindset can emerge in which central logistics management issues can be addressed, understood, and dealt with in order to enhance supply chain effectiveness and innovation. Base
Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. Evolution has therefore favoured the development of phenotypic plasticity in anti-predator defences. The
As the politics of climate change shift from the design of international institutions to the pursuit of decarbonisation across multiple sites, researchers are increasingly calling attention to the geography and politics of transitions. We suggest that recent work has so far been limited by its rather incongruous focus on power as a capacity held by individual agents on the basis of the resources w
Fulltext är ej tillgänglig i elektronisk form. För lån/kopia av tryckt uppsats kontakta Medicinska fakultetens bibliotek, Lunds universitet
Abstract: The creation of new opportunities and ventures due to international entrepreneurs is not something new. Theory suggests that international entrepreneurs in their aim to grow and expand their ventures leave their national boundary looking for new business opportunities. International entrepreneurs face different social, political and cultural barriers. Problem discussion: In this thesis I
