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The rapid horizontal transmission of antibiotic resistance genes on conjugative plasmids between bacterial host cells is a major cause of the accelerating antibiotic resistance crisis. There are currently no experimental platforms for fast and cost-efficient screening of genetic effects on antibiotic resistance transmission by conjugation, which prevents understanding and targeting conjugation. We
Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks. We conducted a meta-analysis of neuropathological studies measuring VEN density in the anterior cingulate cortex or frontoinsular cortex in FTD usin
Contrasting predominant assumptions of women who live with age-related care needs as passive, unagentic, and helpless, this article explores agency exercised in everyday lives permeated by formal home care services. Using a narrative thematic analysis of interviews, diaries, and observations of three Swedish women in later life using home care services, this study examines their diverse ways of na
Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments. Galectin-1 and galectin-3 have been proposed to together be involved in all 10 hallmarks, suggesting that development of a combined galectin-1/3 inhibitor would be beneficial. Specificity toward galectin-1 or -3 c
Aluminum (Al), as a carbon-free energy source and energy carrier, features favorable characteristics regarding its production, transportation, utilization, and recyclability. However, the understanding of Al gas-phase combustion kinetics is still limited. The novelty of this work lies in presenting the first detailed and comprehensive analysis of the Al gas-phase mechanism in the air and steam env
While circular economy (CE) discourse emphasises technology-driven solutions and formal systems, cities in the Global South rely on grassroots waste workers (WWs) in the informal sector, who perform essential circular functions through waste collection, sorting, and recycling. In Delhi, informal WWs contribute substantially to material recovery and fill gaps left by formal solid waste management (
Alterations in cortical morphology have consistently been reported in obsessive-compulsive disorder (OCD). However, the microstructural properties of the cortex in OCD, including intracortical myelination, remain far less explored. The contrast between signal intensity in gray and subjacent white matter from T1-weighted magnetic resonance imaging (MRI), i.e. the gray/white matter contrast (GWC), i
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here we present Proteomics-based Artificial Intelligence for Dementia Diagnosis (ProtAIDe-Dx), a deep joint-learning model
BACKGROUND AND PURPOSE: The breast cancer susceptibility genes BRCA1 and BRCA2 interact with Rad51, one of the central components in the homologous recombination repair pathway. This study evaluates the prognostic and predictive role of BRCA1, BRCA2 and Rad51, individually and as a complex, in breast cancer.MATERIALS AND METHODS: Expression of BRCA1, BRCA2 and Rad51 was investigated using immunohi
Urban streets are an integral part of the public realm. Streets are commonly planned following normative design principles focused on the connectivity of road networks and urban morphology. Beyond their function as mobility infrastructure, streetscapes’ aesthetic, social, and cultural qualities also have an important impact on the experience of the overall urban environment and human well-being. T
BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M
Background: Increasing evidence suggests that total metabolic tumor volume (tMTV) measured before treatment in lymphoma patients undergoing [18F]fluorodeoxyglucose (FDG) PET/CT scans can predict prognosis. However, there is a lack of fast, reliable, and easy-to-perform multilesional segmentation tools with an urgent need to improve tMTV segmentation workflow in clinical practice. Here, we develop
