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We hypothesized that key signaling pathways of glioma genesis might enable the molecular classification of gliomas. Gene coexpression modules around epidermal growth factor receptor (EGFR) (EM, 29 genes) or platelet derived growth factor receptor A (PDGFRA) (PM, 40 genes) in gliomas were identified. Based on EM and PM expression signatures, nonnegative matrix factorization reproducibly clustered 1
IMPORTANCE Fluid overload occurring as a consequence of overly aggressive fluid resuscitation may adversely affect outcome in hemodynamically unstable critically ill patients. Therefore, following the initial fluid resuscitation, it is important to identify which patients will benefit from further fluid administration. OBJECTIVE To identify predictors of fluid responsiveness in hemodynamically uns
The ultrastructure of the paired nerves, previously called frontal organ or X-organ, in copepod crustaceans was investigated. These nerves, run- ning from the anterior margin of the brain to the frontal edge of the animals, are found to contain the dendrites of three types of morpho- logically different sensory neurons. The first unit consists of two dendrites (distinguished
Building materials differ in their susceptibility to mould growth. Wood is a material often considered to have a low mould resistance. However, wood is not a homogenous material and different characteristics of the material are expected to have an impact on mould growth. In this paper, it was shown that wood species (pine or spruce), sawing pattern (centre-board or side-board) and surface structur
This chapter addresses potential political implications of social media by looking into everyday appropriations of the political opportunities offered to active citizens. It presents and analyses data from interviews with 33 Swedish online participating citizens to gain insight into how they work both with separate and in-between (cross) internet applications as part of their political participati
Recent evidence has revealed the role of mechanical cues in the development of shapes in organisms. This thesis is an effort to test some of the fundamental hypotheses about the relation between mechanics and patterning in plants. To do this, we develop mechanical models designed to include specific features of plant cell walls. These are heterogeneous stiffness and material anisotropy as well as
Distributed solar photovoltaic systems are considered an important renewable energy source for meeting renewable energy targets and mitigating climate change. In several markets, emerging firms have established new business models to offer residential customers solar panel systems. In California, the third-party ownership business model has been successfully established during the last decade, and
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
In networked control systems it is desirable to have efficient wireless communication (saving energy and bandwidth) while still ensuring good control performance. By abandoning periodic sampling, communication can be made more efficient by sampling and updating the control signal only "when required" based on the system’s behaviour. This is the concept of event-based control. In this work we consi
This paper presents a review of particle deposition research in film-cooled gas turbines based on the recent open literature. Factors affecting deposition capture efficiency and film cooling effectiveness are analyzed. Experimental studies are summarized into two discussions in actual and virtual deposition environments. For investigation in virtual deposition environments, available and reasonabl
As almost all combustion processes of practical interest take place in the presence of turbulence, the development of the increasingly refined turbulence–chemistry interaction (TCI) models has led to highly sophisticated approaches. Nearly all of the studies comparing different models focus on stable premixed/non-premixed flame configurations. In this work, the focus is on well-documented, lean pr
In this study, the effects of adding a microporous layer (MPL) as well as the impact of its physical properties on polymer electrolyte fuel cell (PEMFC) performance with serpentine flow channels were investigated. In addition, numerical simulations were performed to reveal the effect of relative humidity and operating temperature. It is indicated that adding an extra between the gas diffusion laye
The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has been lacking. Here, we used whole-genome genotyping of 1454 DLB cases and 1525 controls to assess copy number variability. We used 2 algorithms to confidently detect CNVs, performed a case-control association analysis, screened for candidat
There is currently a lack of representative, systematic and harmonised greenhouse gas (GHG) observations covering the variety of natural and human-altered biomes that occur in Africa. This impedes the long-term assessment of the drivers of climate change, in addition to their impacts and feedback loops at the continental scale, but also limits our understanding of the contribution of the African c
The ontogeny of the pelturine olenid trilobite Leptoplastides salteri (Callaway, 1877) from the Shineton Shales, Shropshire, England, was first described in 1925 by Frank Raw. Since that time, scanning electron microscopy and other new technologies have revealed many more details of structure, of early developmental stages in particular, than were available to Raw. Whereas protaspides are not pres
Background: Obesity is a well-known risk factor for osteoarthritis (OA). The majority of obesity research in OA is performed using self-reported BMI-data, however, its validity in persons with OA is unknown. The aim of this study was to compare the validity of self-reported body mass index (BMI) in persons with and without clinical osteoarthritis (OA) in a population-based survey. Methods: Height
Patients with cold urticaria can after exposure to cold air or infusions react with hypotension and cardiovascular collapse. We here report on a patient having a severe cold urticaria who because of angina required myocardial revascularization: She was successfully operated in normothermic cardiopulmonary bypass with cardioplegia.
