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Aims: In a co-twin control design, we aimed to examine whether individuals who initiate metformin treatment have an altered risk of incident diagnosis of osteoarthritis (OA), for up to 11 years after starting the treatment, compared with their non-treated co-twin. Methods: In all twin pairs different for metformin treatment (N=1 261 pairs) and all eligible twins/singletons (N=52 341) aged 35–75 ye
Aim: To model the long-term cost-effectiveness of scaling up two prevention interventions against type 2 diabetes mellitus (T2DM), i.e. community mobilisation through participatory learning and action (PLA) and mHealth mobile phone messaging, implemented in rural Bangladesh as part of the “DMagic” trial. Methods: A health-economic Markov model of the three-arm, cluster-randomised controlled DMagic
Despite rapid clinical translation, induced pluripotent stem cell (iPSC)-derived therapies face limited global adoption. Harmonized quality control (QC) remains absent, with even fundamental parameters evaluated inconsistently across laboratories. To address this, we conducted two international Quality Assessment Rounds (QARs): QAR 2019 (18 sites, 11 countries) and QAR 2023 (23 sites, 12 countries
INTRODUCTION: Anaemia in patients having surgery is associated with worse postoperative outcomes. Management with intravenous iron is an attractive therapeutic option, however, pre-operative intravenous iron administration is challenging. Evidence from interventional trials suggests that the greatest benefit is after hospital discharge. As anaemia is common after surgery, this meta-analysis aimed
The circular economy is a concept which has received increased interest from built environment research and industry in recent years. This study explores two circular business models of adaptive reuse and shared spaces through employing a single-case study of a former factory, refurbished to shared offices and workshops. As circular economy has been criticised for ignoring social sustainability, w
This work investigates lightweight personalisation of micro-electro-mechanical systems (MEMS)-based wearables using a public padel database as a case study. We compare a centralised CNN model, single-user models and two fine-tuning schemes (full and last-layer) on wrist-worn IMU data from 23 players and 13 stroke classes. Personalised models with data augmentation achieve weighted F1-scores above
The link between regional tau load and clinical manifestation of Alzheimer's disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progression of tau pathology mirrors the functional connections from temporal lobe epicentres. However, given the limited spatial heterogeneity of tau in typical AD, at
The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1667922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model
We consider the numerical approximation of the stochastic complex Ginzburg-Landau equation with additive noise on the one-dimensional torus. The complex nature of the equation means that many of the standard approaches developed for stochastic partial differential equations cannot be directly applied. We use an energy approach to prove an existence and uniqueness result as well as to obtain moment
”Hur kan det europeiska storstadstornet rädda staden?” Ungefär så, och sett i motsats till den anglosaxiska skyskrapan, kan det projekt som genomsyrar den här boken formuleras..."
Summary: In this meta-analysis of international cohorts, current smoking is confirmed as a significant BMD-independent predictor of future fracture with a stronger relationship in men than in women. A causative and reversible effect of smoking on fracture risk is suggested by past smoking having a significantly lower risk than current smoking. Purpose: In this meta-analysis of international cohort
Neophobia, or aversion to novelty, is important for adaptability and survival as it influences the ways in which animals navigate risk and interact with their environments. Across individuals, species and other taxonomic levels, neophobia is known to vary considerably, but our understanding of the wider ecological drivers of neophobia is hampered by a lack of comparative multispecies studies using
Sexual dysfunction (SD), more specifically vasculogenic erectile dysfunction (ED) in men and female sexual arousal disorder (FSAD) in women, is increasingly recognized as a marker of cardiovascular disease (CVD). While extensive literature documents vasculogenic ED as an early warning sign of coronary artery disease (CAD) and other atherosclerotic manifestations, the evidence for analogous phenome
The growing demand for lithium-ion batteries has intensified the need for efficient processes to produce lithium hydroxide (LiOH), a compound with superior performance in cathode manufacturing compared to lithium carbonate. Conventional LiOH production from brine involves the lime conversion of lithium carbonate, which increases costs and process complexity. In this study, Donnan dialysis using an
A calibration of the ATLAS flavour-tagging algorithms using a new calibration procedure based on optimal transportation maps is presented. Simultaneous, continuous corrections to the b-jet, c-jet, and light-flavour jet classification probabilities from jet-tagging algorithms in simulation are derived for b-jets using tt¯→eμννbb data. After application of the derived calibration maps, closure betwe
Randomized controlled trials (RCTs) of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS) have produced outcomes varying from no effect at all to high efficacy and durable effects over time. This review analyzed differences in the protocols used in FMT RCTs for IBS in the recently published literature with the aim of identifying the factors responsible for the s
As circular economy (CE) strategies become mainstream in policy and business practice, concerns have emerged about their narrow focus on techno-economic efficiency, often associated with “weak sustainability”. In parallel, a growing number of grassroots, public, and hybrid initiatives have emerged at the local level, bridging product and material recovery with social inclusion, education, and ecol
OBJECTIVE: Explore women's subjective perceptions of healing from perineal tears in childbirth, with a particular focus on infection-related symptoms.METHODS: Women enrolled in a randomized-controlled-trial (ClinicalTrials, NCT02863874) were invited to complete a questionnaire at one- and eight-weeks postpartum. Infection-diagnosis was obtained separately through medical records.RESULTS: 1462 wome
Extreme heat is both a chronic and acute threat to the health and well-being of urban populations. The aim of this paper is to share experiences from using a range of quantitative and qualitative methods to conduct research on extreme indoor heat, plus highlight the benefits of taking this more holistic approach. Research conducted in urban Ghana measured temperatures in homes and workplaces, eval
Culture and creativity are active but often overlooked processes in contemporary urbanisation. This paper contributes to scholarship on the cultural and creative industries, as well as urban placemaking on the margins, by adopting a placemaking approach in which artists are positioned at the centre of the analysis. The focus is on why artists choose to be located away from national cultural hubs,
