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We demonstrate self-compression of 173 fs pulses centered at 1030 nm down to 19.5 fs through electro-optic phase modulation by the phonon-polariton waves generated in a phase-matched intra-pulse difference-frequency mixing.

The present study examined whether students experience an increase in their general perceived self-efficacythrough international academic mobility. Two hundred and twenty-one students at Leuphana UniversityLüneburg were enrolled in a test-retest study with two points of measurement including a time interval of ap-proximately six months. Perceived self-efficacy was measured in a group of sojourners

Renal dysfunction is a major risk factor for premature death and has been studied extensively. A new renal syndrome, shrunken pore syndrome (SPS), confers higher mortality in all studied populations. SPS is a condition in which cystatin C-based estimation of glomerular filtration rate (eGFRcystatin C) is ≥ 60% than creatinine-based estimation of glomerular filtration rate (eGFRcreatinine). We aime

UNLABELLED: Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable tumor-targeting properties. Studies concerning the influence of chelators on biodistribution of (99m)Tc-labeled Affibody molecules demonstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution profile in vivo a

Mutated Nucleophosmin 1 (NPM1) is the most common genetic alteration in acute myeloid leukemia (AML), found in approximately 30% of cases. Although mutations in this gene are considered favorable according to current risk stratification guidelines, a large fraction of patients will suffer from relapse, demonstrating the urgent need for new treatment options. Therefore, we aimed to identify cell su

To make the content of moving images and audio-visual media available to a visually impaired audience, a sighted interpreter can provide audio description (AD). AD is a verbal description of visual events, aiming to increase the accessibility of visual information and to provide a visually impaired audience with a richer and more detailed understanding and experience of, for instance, films. To ac

The multi-zone modelling concept could be a good alternative to two-zone modelling and CFD modelling for some situations when performing fire safety designs. However, few such models exist, and the evaluation of the concept is scarce. This paper is dedicated to study the multi-zone modelling concept and its usefulness in fire safety engineering by benchmarking it against experimental data and simu

Optical microscopy has revolutionized the way we understand our world and has become a crucial tool in a range of disciplines such as biology, physics, chemistry, and material sciences. The development of new microscopy techniques has been capital to its success and wide applicability. A prominent example is the recent development of methods that allow imaging in three dimensions. This has been a

The engram encoding the interval between the conditional stimulus (CS) and the unconditional stimulus (US) in eyeblink conditioning resides within a small population of cerebellar Purkinje cells. CSs activate this engram to produce a pause in the spontaneous firing rate of the cell, which times the CS-conditional blink. We developed a Bayesian algorithm that finds pause onsets and offsets in the r

Agricultural ecosystem water use efficiency (WUE) is an important indicator reflecting carbon-water coupling, but its control mechanisms in managed fields remain unclear. In order to reveal the influencing factors of WUE in the agricultural field under mulched drip irrigation (DM), we carried out the 8-year continuous observations in a maize field from Northwestern China. The structural equation m

Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within th

BackgroundAssessing pain in the intensive care unit (ICU) is challenging. Due to intubation and sedation, communication can be limited. International guidelines recommend assessing pain with instruments based on behavioral parameters when critically ill patients are unable to self-report their pain level. One of the recommended instruments, the Behavioral Pain Scale (BPS), has shown good validity

Background: Access to emergency and essential surgical care is still unmet and accessibility is disproportionately inequitable in Ethiopia and other low-and middle-income countries. The aim of this study was to assess surgical care access in terms of capability, capacity, and timeliness of care in different levels of health care in Ethiopia. Methods: A cross-sectional study with retrospective data

Interactions of hard partons in the Quark Gluon Plasma (QGP) created with relativistic heavy ion collisions lead to characteristic modifications of the internal structure of reconstructed jets. A large part of the observed jet sub-structure modifications stem from the QGP’s response to energy and momentum deposited by hard partons. Good control over medium response in theoretical calculations is t

We combine socioeconomic data from a large-scale household survey with historical climate data to map the climate sensitivity of availability and access dimensions of food security in Mali, and infer the ways in which at-risk communities may have been impacted by persistent climatic shift. Thirty years after 1982–1984, the period of most intense drought during the protracted late 20th century dryi