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A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for cervical cancer is based on data from 1 meta-analysis and 34 randomize
Short- and long-term adaptation (two months and one year respectively) to bilateral subcutaneous mastectomy was studied in twenty-five consecutive patients operated upon at the Department of Plastic and Reconstructive Surgery, Malmo, Sweden. The results were related to preoperative personality and psychosocial profiles. Postoperative difficulties in accepting the surgical result, sexual dysfunctio
We show that the "exponential decay parameter" of the waiting time in a Markov-modulated M/G/1 queue is no larger than that of the corresponding M/G/1 queue with "averaged" parameters, and we give a necessary and sufficient condition for equality. We also explore the effect of speeding up the modulation process. A key tool is a Markov-modulated fluid model.
The formation of a capillary phase in segregating mixed polymer solutions confined between two planar walls is modeled by using a lattice mean-field theory for flexible polymers in solution. A capillary-induced phase separation (CIPS) may appear in systems where the two polymer components display different preference for the wall, the preference being either of energetic or entropic origin. A long
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-
High-spin states of the isotopes In-103,In-105,In-107,In-109 have been investigated using in-beam gamma-ray spectroscopic methods. Results from three different experiments are presented. Targets of Fe-54, Cr-50, and Mo-92 were bombarded by a 270 and 261 MeV Ni-58 beam and by a 95 MeV F-19 beam, respectively. Reaction channel separation was achieved with a charged-particle detector array and in the
We describe a device to study reactions relevant for the Single Event Effect (SEE) in microelectronics by means of 200A and 300AMeV, inverse kinematics, Si + H and Si + D reactions. The work is focused on the possibility to measure Z = 2-14 projectile fragments as efficiently as possible. During commissioning and first experiments the fourth quadrant of the CELSIUS storage ring acted as a spectrom
Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations
Isometric force, glycogen phosphorylase activity and lactate production were measured under conditions known to alter intracellular Ca2+ and cAMP to assess the role of these messengers in the coordination of metabolism with contractility in rat portal vein. Total phosphorylase (a + b) activity, was independent of treatment. The activity ratio phosphorylase activity ratio in the presence of isoprot
An exact calculation is given for the function Bx(n) which enters the Hohenberg-Kohn-Sham expansion, in powers of ▿n(r), of the echange energy of an inhomogeneous eletron gas. The calculation is made for arbitrary inter-particle interaction. It is shown that the gradient expansion does not exist, in the case of Coulomb interaction, unless correlations are taken into account.
Various applications need an electric machine that can provide a wide range of torque over a broad range of rotation speed and temperature. Dynamic testing, where the machine acceleration is compared to the deceleration slope, allows to scan through a wide scope of operation points with insignificant temperature rise. Therefore, the goal of this paper is to analyse the consistency of the rapid exp
Availability of safe, edible food is essential. Food shortage has caused many wars and encouraged people to try to preserve food for a longer time, allowing storage and transport, often in some kind of package/container. The USA showed the way in developing the food sector and already prior to the 2nd World War they had self-service stores filled with packed goods. Europe, however, had to wait to
Objective: A modified version of the widely used pen FlexPen® (FP), called Next Generation FlexPen® (NGFP), has been designed to reduce the injection force with this pen. In this study, the injection force of NGFP was compared with another insulin pen, SoloStar® (SS). Research design/methods: The injection force of 24 pens of each type: NGFP fitted with a NovoFine® 32G Tip ETW 6 mm needle; SS fitt
[Context and Motivation] The main role of requirements engineering (RE) is to guide development projects towards implementing products that will appeal to customers. To effectively achieve this RE needs to be coordinated with and clearly communicated to the later software development activities. [Question/Problem] Communication gaps between RE and other development activities reduce coordination a
The chapter discusses some design challenges encountered when developing a conversational pedagogical agent. By tracing the historical roots of pedagogical agents in Intelligent Tutoring Systems (ITS), we discern central developments of creating an agent that is both knowledgeable and fosters a social relationship with the learner. Some main challenges when attempting to develop a pedagogical age
