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Strategies to strengthen elective surgery systems during the SARS-CoV-2 pandemic : systematic review and framework development

Surgical systems are complex and susceptible to external system pressures. The SARS-CoV-2 pandemic and its impact on elective surgery illustrated this. The reassignment of resources to the acute care of patients with COVID-19 led to cancellations of elective services that varied according to surges of the pandemic. Overall, it was estimated that more than 28 million operations were cancelled or po

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood : the TEDDY study

Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of

hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden

We have screened 17 Southern Sweden individuals/families with suspected hereditary non-polyposis colorectal cancer (HNPCC) for mutations in the DNA-mismatch repair genes hMLH1, hMSH2 and hMSH6 using denaturing gradient gel electrophoresis, protein truncation test and direct DNA sequencing. The families were selected on the basis of a family history of HNPCC-related tumors or the occurrence of meta

Kunskapssammanställning om sprutfria kantzoner

Det finns en rad anledningar till varför ett allt intensivare brukande avjordbrukslandskapen i många industrialiserade länder, t.ex. i Europa, lett till att denbiologiska mångfalden minskat. Även om förlusten av mer eller mindre naturliga habitat är en viktig orsak till den minskade mångfalden, har den biologiskamångfalden påverkats starkt av intensivare odling på fälten. En viktig orsak till dett

Blodceller kan ge viktiga svar om cancer – Vetenskap och Hälsa

Blodceller kan ge viktiga svar om cancer – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Blodceller kan ge viktiga svar om cancer 2014-06-19 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Det behövs bättre förståelse av mekanismerna bako

https://www.vetenskaphalsa.se/blodceller-kan-ge-viktiga-svar-om-cancer/ - 2026-06-19

Phagocytosis by neutrophils - studies on phagosome dynamics and membrane traffic modulation by Streptococcus pyogenes

Popular Abstract in Swedish Hur lurar mördarbakterier våra celler? Neutrofiler och fagocytos räddar liv Utan vårt immunförsvar så skulle vi snabbt dö i infektioner från mikroorganismer. Det består ett komplicerat system av celler och molekyler som tillsammans kan klara av att stå emot attacker från bakterier, virus, svampar eller parasiter. Cellerna i immunförsvaret utgörs av vita blodkroppar ochNeutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan

X-ray emission spectroscopy of bulk liquid water in "no-man's land".

The structure of bulk liquid water was recently probed by x-ray scattering below the temperature limit of homogeneous nucleation (TH) of ∼232 K [J. A. Sellberg et al., Nature 510, 381-384 (2014)]. Here, we utilize a similar approach to study the structure of bulk liquid water below TH using oxygen K-edge x-ray emission spectroscopy (XES). Based on previous XES experiments [T. Tokushima et al., Che

Vi och dom och alla dom andra andra på Komvux : Etnicitet, genus och klass i samspel

Popular Abstract in Swedish Syftet med den här avhandlingen har varit att förstå hur grupper av vi och dom skapas och består, framför allt inom utbildning och skola, och särskilt inom gymnasiala Komvux. I vardagligt tal menar människor oftast att dom är invandrare, medan vi är svenskar. Jag har visat att denna uppdelning, som sker nästan automatiskt, är alltför förenklad och svart-vit. Ett undersyThis thesis, set in an educational context (Swedish Komvux, high school adult education), deals with how groups of us and them are constructed, changed and reproduced. In order to understand the processes of us and them I have looked at the interconnections between gender, ethnicity and class utilising participant observations and semi-structured interviews. The main theoretical points of departu

Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: In addition to their possible direct biological effects, plasma carotenoids can be used as biochemical markers of fruit and vegetable consumption for identifying diet-disease associations in epidemiological studies. Few studies have compared levels of these carotenoids between countries in Europe. Objective: Our aim was to assess the variability of plasma carotenoid levels within the c

Monoglyceride Lipase and Hormone-Sensitive Lipase - Molecular and structural aspects

Triglycerides in the adipocyte are hydrolysed by means of three consecutive reactions through the combined action of two lipases: hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). HSL catalyses the first and rate-limiting step, i.e. the hydrolysis of triglycerides to diglycerides, and the subsequent hydrolysis of diglycerides and monoglycerides. However, MGL is needed to assure comple

Vänskap och organisering : En studie av Fountain House-rörelsen

Popular Abstract in Swedish Avhandlingen ”Vänskap och organisering. En studie av Fountain House-rörelsen” tar sin utgångspunkt i frågan om vad som händer när mentalsjukhusen läggs ner. Bakgrunden är den process som kallas avinstitutionaliseringen, och tidens betoning på integrering, normalisering och självbestämmande. Omstruktureringen av mentalvården har inte varit problemfri i något land. Många The Fountain House Movement – or the Clubhouse Movement - is an organization for community support, meeting the needs of adults suffering from mental illness. It was founded by a self-help group among discharged patients in New York in the 1940s. Today there are more than 300 clubhouses around the world. The aim of this dissertation is to characterize, interpret and understand the Clubhouse Moveme

Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

Popular Abstract in Swedish Multipel organdysfunktion-syndromet (MODS), dvs utveckling av sviktande funktion i ett flertal organsystem inkluderande lunga, lever, magtarmkanal, hjärta, koagulation, hjärna m fl, kan utvecklas vid ett flertal olika tillstånd. MODS kan uppkomma vid primära infektioner i buken typ inflammation och perforation (bristning) av någon del av magtarmkanalen, akut bukspottkörMultiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zym

Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

Popular Abstract in Swedish Inflammationsreaktioner kan utlösas i alla vävnader som ett generellt svar på olika stimuli. En defekt eller utebliven reaktion kan leda till svåra infektion sjukdomar. De olika stimuli som startar den inflammatoriska processen frisätter olika inflammationsmediatorer i vävnaden. Dessa kan vara lagrade i celler och frisätts till omgivningen. Vad gäller arachidonsyra prodLeukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. Cell-cell and cell-matrix complexes of epithelial cells are inter

Nature and the Social Sciences : Examples from the Electricity and Waste Sectors

The book has two interrelated objectives. One objective is meta-theoretical and concerns the exploration of theoretical debates connected to issues of studying society and environmental problems; another objective is empirical/analytical, referring to the analysis of "green" public participation in the electricity and waste sectors in Sweden, and partly in the Netherlands as well as the UK. The me

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we ide

Three-body correlations in electromagnetic dissociation of Borromean nuclei: The He-6 case

Dissociation of 6He on a lead target has been studied at 240 MeV/u. The four-momenta of the two neutrons in coincidence with greek small letter alpha-particles have been measured and used to reconstruct the three-body energy and angular correlations in the final state. For the first time, three-body correlations were included in the analysis of the 6He dissociation data, and compared with calculat

Thermal history of the Phanerozoic sedimentary succession of Skåne, southern Sweden, and implications for applied geology

Popular Abstract in Swedish Sedimentära bergarter såsom t.ex. sandstenar och lerskiffrar, bildas genom att lösa sediment (t.ex. sand och lera) ”bakas” hårda när de sjunker ned i jordskorpan. Anledningen till att många lagerföljder rör sig nedåt i jordskorpan beror till viss del på de ovanliggande sedimentens tyngd, men är i huvudsak ett resultat av de platt-tektoniska rörelser som hela tiden påverPost-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone

Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma

Background: Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines. Patients and methods: The clinico-pathological features of 38 HIV-negative patients with IVL were reviewed to define efficacy of chemotherapy in these malignancies. Clinical characteristics of 22 patients treated with chemotherapy and of 16 untreated patients were compared in order to understand be