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Conventional views of the police support a norm of emotion management. Aspiring police officers are taught not to show pain or fear and to display an image of control and assertion. If failing to convey such emotions officers might be considered too weak or simply not “man enough” for the job. This is also the case concerning border guarding and border police conduct. This study draws on data gath

We used an invivo small hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells invivo and for human leukemia cells in xenotransplantation studies. In leukemia cells, Itgb3 knockdown impaired homing, downregulated LSC transcriptional programs, and induced diffe

The engine concept partially premixed combustion (PPC) has proved higher gross indicated efficiency compared to conventional diesel combustion engines. The relatively simple implementation of the concept is an advantage, however, high gas exchange losses has made its use challenging in multi-cylinder heavy duty engines. With high rates of exhaust gas recirculation (EGR) to dilute the charge and he

Despite the impressive growth of smart city initiatives worldwide, an organizational theory of smart city has yet to be developed, and we lack models addressing the unprecedented organizational and management challenges that emerge in smart city contexts. Traditional models are often of little use, because smart cities pursue different goals than traditional organizations, are based on networked,

Because of the amphiphilic properties of alcohols, hydrophobic hydration is important in the alcohol-water system. In the present paper we employ X-ray photoelectron spectroscopy (XPS) to investigate the bulk and surface molecular structure of ethanol-water mixtures from 0.2 to 95 mol %. The observed XPS binding energy splitting between the methyl C 1s and hydroxymethyl C 1s groups (BES-[CH3-CH2OH

The aim of this work is the development of a thermodynamically consistent fully coupled thermo-viscoplastic material model for metals.The model is based on a split of the free energy into a thermo-elastic, a thermo-plastic and a purely thermal part and covers nonlinear cold-work hardening and thermal softening.Nonlinear temperature dependent effects are accounted for the elastic moduli, the plasti

In a solid-state host, attractive electron-electron interactions can lead to the formation of local electron pairs which play an important role in the understanding of prominent phenomena such as high T c superconductivity and the pseudogap phase. Recently, evidence of a paired ground state without superconductivity was demonstrated at the level of single electrons in quantum dots at the interface

The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridiza

The results from a round-robin study in which practicing fire safety engineers simulated the same scenario are presented in this paper. The simulation task included the simulation of an 800 mm heptane pool in a three-room apartment. The participants, representing eight Swedish consultancy firms, simulated the well-specified scenario with FDS 5. The participants received information about the build

The partial reinforcement extinction effect (PREE) is an experimentally established phenomenon: behavioural response to a given stimulus is more persistent when previously inconsistently rewarded than when consistently rewarded. This phenomenon is, however, controversial in animal/human learning theory. Contradictory findings exist regarding when the PREE occurs. One body of research has found a w

In this paper, we consider a version of the functional Hodrick-Prescott filter for functional time series. We show that the associated optimal smoothing operator preserves the ‘noise-to-signal ratio’ structure. Moreover, as the main result, we propose a consistent estimator of this optimal smoothing operator.

This protocol details the induction of a hemogenic program in mouse embryonic fibroblasts (MEFs) via overexpression of transcription factors (TFs). We first designed a reporter screen using MEFs from human CD34-tTA/TetO-H2BGFP (34/H2BGFP) double transgenic mice. CD34+ cells from these mice label H2B histones with GFP, and cease labeling upon addition of doxycycline (DOX). MEFS were transduced with

Marketing has historically been entangled with the study of geography, which has become a very popular focus in the marketing literature nowadays. However, spatially-oriented perspectives in marketing tend to rest on a conceptual divide between place-oriented and space-oriented thinking, thus inhibiting the production of more eclectic and creative spatial knowledge. This conceptual paper endeavors

Two approaches to the macro basis function (MBF) method that target interconnected subdomains have been adapted to finite linear arrays, and benchmarked against each other in order to estimate their performance with respect to the strong near field coupling that occurs under the endfire mode operation. The methods, here referred to as methods A and B, are based on the synthetic function and charac

Globally, waste volumes are increasing rapidly and the World Bank estimates a 70% global increase in municipal solid waste until 2025. Waste may have serious environmental consequences and there is a strong correlation between solid waste generation rates and greenhouse gas emissions. These two observations alone indicate that this development is not sustainable. Recycling is one of the most impor

Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than migraine such as hypertension, depression and epilepsy. During the last decade, however, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for prevention of mi

Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. However, long-term analysis of human iPS cell-derived dopaminergic neurons in primate PD models has never been performed to our knowledge. Here we show that human iPS cell-derived dopaminergic progenitor cells

Biological nitrogen removal in a one sludge system based on alternating operation is described. Results from a half year of operation in a plant designed for a population of 33,000 people are presented showing 90% removal of total-nitrogen, 98% removal of BOD and 74% removal of total-phosphorus (without addition of chemicals). An experiment showing the parameter variation in the plant over 24 hour

Global comparative studies of the links between economic growth, carbon emissions and ecological footprints as well as social inequality demonstrate that current Western production and consumption patterns and welfare standards are incompatible with environmental limits and IPCC climate targets. To allow for catch-up' development in poorer countries, rich countries would need to ‘degrow’. Against