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The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C,
Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest–enriched gene MOXD1 associates with advanc
We developed a panel of 44 nuclear genetic markers and applied this to two hybridizing species of marbled newts in the north (Triturus marmoratus) and the south (Triturus pygmaeus) of the Iberian Peninsula, to investigate pattern and process of interspecific gene flow. The northernmost occurrence of T. pygmaeus genetic material was in a T. marmoratus population north of the Vouga river estuary. Th
This introductory chapter argues that attention to the contemporary contexts in which Bibles abide provides a chance but also a challenge for biblical scholarship. It discusses the broader concerns at play in taking contemporary contexts seriously for any and all biblical interpretation, before turning to Contextual Bible Study as a specific approach to reading the Bible. The chapter foregrounds h
A prototype clinical brain SPECT insert has been designed for use in simultaneous SPECT/MRI. The system utilises novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI
Background: A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing the detectability of small lesions without increasing image noise. The combination of new detector technologies and new reconstruction algorithms has been found to increase image
Abstract in UndeterminedFlow-induced oscillation of an elastically supported circular cylinder subject to an incompressible fluid at Re=100 and 400 has been studied using three-dimensional simulations. The cylinder is either subjected to a uniform flow in an unconfined surrounding or confined by rectangular channel, i.e. the cylinder is confined in both the span-wise and the cross-stream direction
Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (SNPs) either involving CpG sequences in extended 5'- regulatory regions of candida
BACKGROUND AND OBJECTIVES: The extremely rare Rh null phenotype is characterized by the absence of all Rh antigens on erythrocytes. It is divided into the regulator and amorph types based on the underlying genetic background. The more common regulator type depends on critical variants silencing RHAG, which encodes RhAG glycoprotein, necessary for RhD/RhCE expression. Rh null cells have altered e
BACKGROUND: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17.OBJECTIVES: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations.METHODS: We report an association analysis of recentl
Purpose This study aims to propose a cybersecurity framework that prioritizes sustainability in the manufacturing sector by identifying necessary resources and capabilities for effective cybersecurity management. The proposed framework aims to enhance resource protection and safeguard data confidentiality, integrity and accessibility, provide proactive steps for predicting cyber threats and highli
In language acquisition it is important to imitate the native speakers of the language. For the young child it is natural to imitate both the language and the behaviour of the culture. Imitation, or adaptation (Markham 1997), is also useful in second language acquisition to learn how to pronounce the words and to learn the prosody of the language. For most people it is difficult to learn to speak
