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Background Multiple sclerosis ( MS) is a common disease with considerable risk for disability. Optic neuritis ( ON) is a common first symptom of MS but it can also remain an isolated episode. Therefore, predicting the outcome of ON has gained in importance, particularly in light of current discussions of early disease modifying treatments in individuals at risk of developing MS. We reported previo
Late Ordovician jawed polychaete (Annelida) faunas from the type Cincinnatian region in the tri-state area of Indiana, Ohio. and Kentucky, North America, are discussed on the basis of an extensive and unique collection of more than 50,000 well-preserved scolecodonts. Approximately 40 to 50 multi-element species belonging to a dozen families are identified. Scolecodonts of polychaetes with prionogn
Coupled cluster methods are compared to multiconfigurational second-order perturbation theory in a study of the high spin d(x)s(2) -> d(x+1)s(1) excitations in first, second, and third row transition metals. Large basis sets of the atomic natural orbital type are used. Scalar relativistic effects are included using the Douglas-Kroll-Hess Hamiltonian. The effect of spin-orbit coupling is demonstrat
Popular Abstract in Swedish I tider av samhällsförändringar uppträder nya organisationer. De är beroende av att mobilisera resurser från en omgivning som präglas av en gammal ordning. De måste då anpassa sig för att överleva. I denna process är härmandet en central mekanism. Nya organisationer lär sig att överleva genom att härma sin omgivning. Detta leder i sin tur till att de tenderar att bli alNew organizations emerge in times of social change. Their survival depends on their ability to mobilize resources in an environment defined by an old order, and thus they must adapt to it. Since new organizations learn how to adapt by mimicking already succesful organizations, their structure tend to become increasingly similar to the structure of those organizations. The thesis tells the story of
Oxygen and glucose deprivation (OGD) in cell cultures is generally studied in a medium, such as artificial cerebrospinal fluid (CSF), with an ion composition similar to that of the extracellular fluid of the normal brain (2 to 4 mmol/L K+, 2 to 3 mmol/L Ca2+; pH 7.4). Because the distribution of ions across cell membranes dramatically shifts during ischemia, the authors exposed mouse organotypic h
Objective: To investigate the effects of cold storage and vinegar addition on glycaemic and insulinaemic responses to a potato meal in healthy subjects. Subjects and setting: A total of 13 healthy subjects volunteered for the study, and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, Sweden. Experimental design and test meals: The study included four meals; fresh
Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose
The pancreatic islets are richly innervated by autonomic nerves. The islet parasympathetic nerves emanate from intrapancreatic ganglia, which are controlled by preganglionic vagal nerves. The islet sympathetic nerves are postganglionic with the nerve cell bodies located in ganglia outside the pancreas. The sensory nerves originate from dorsal root ganglia near the spinal cord. Inside the islets, n
The reaction mechanism of propane ammoxidation was studied on an Al-Sb-V-W-oxide catalyst using a TAP-2 reactor system. Analyses of the responses from both high-speed pulse transients with reactants and TPD experiments were performed. Since the ammoxidation process with three reactants proceeds from propane to acrylonitrile over propylene as an intermediate, the experiments comprised oxidation of
The mechanical design of the EUROBALL neutron wall and neutron detectors, and their performance measured with a Cm-246,Cm-248 fission source are described. The array consists of 15 pseudohexaconical detector units subdivided into three, 149 mm high, hermetically separated segments and a smaller central pentagonal unit subdivided into five segments. The detectors are filled with Bicron BC501A liqui
We demonstrate spatial interference fringe pattern by simultaneous one- and three-photon absorption of UV and near-IR femitosecond pulses in thin film organic solid at room temperature. We use organic dendrimers that are specially designed to have strong fluorescence and very large three-photon absorption cross-section. High fringe visibility allows the quantum interference to be observed by eye.
An one-step procedure using a nuclear isolation medium containing propidium iodide has been found to be a suitable preparation technique for flow cytometric DNA analysis in breast cancer samples. In the case of cervical squamous carcinoma, a pretreatment with HCl seems to be a methodological improvement. One advantage with the HCl modification is that some "false" near-diploid cell populations are
Despite advances in the treatment of postoperative pain, nearly 30% of patients experience moderate to severe pain following major surgery. The present thesis includes four studies intended to evaluate important aspects of postoperative pain. In studies I and II, patient-controlled epidural analgesia (PCEA, n = 1,670), using local anesthetics and morphine, was associated with significantly lower
Salla disease is a lysosomal storage disorder of unknown etiology, characterized biochemically by increased urinary excretion of N-acetylneuraminic acid. This compound has now been shown to occur in abnormally large amounts in liver and cultured skin fibroblasts from these patients. Quantification of N-acetylneuraminic acid was performed using a new gas-chromatography/mass spectrometric single-ion
