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The first study with a PID controller based automatic drug delivery system for propofol anesthesia in children is presented. It is shown that a robustly tuned PID controller is capable of delivering safe and adequate anesthesia. The design process of the control system is reviewed. Results are discussed and compared to those of two previous studies in adults.
An augmented version of the traditional relay feedback experiment is proposed. It aims at producing an input with energy concentrated to a frequency band, corresponding to a certain phase sector of the Nyquist curve of the process to be identified. A non-convex problem is formulated. Sub-optimal, but efficient, algorithms are developed.
The paper reports a study of a radio counselling program broadcast once a week on a Swedish state radio channel. The program episodes consist of telephone conversations between a psychotherapist and persons seeking help in dealing with life’s troubles such as difficulties in relations between parents and children or between spouses, coping with anxiety, overcoming traumatic childhood experiences o
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries a risk of sudden death. We aimed to assess whether vectorcardiographic (VCG) parameters directed toward the right heart and a measured angle of the S-wave would help differentiate ARVD/C with otherwise normal electrocardiograms from controls. Methods: Task Force 2010 definite ARVD/C criteria were met for all pat
Background: Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of metastastic spread in a clinical population are limited. Methods: A case-control design including 1357 primary breast cancers was used to study three distinct clinical patterns of metastasis, which occur within the first six mon
Relapse is a major problem in acute myeloid leukemia (AML) and adversely affects survival. In this phase 2 study, we investigated the effect of vaccination with dendritic cells (DCs) electroporated with Wilms’ tumor 1 (WT1) messenger RNA (mRNA) as postremission treatment in 30 patients with AML at very high risk of relapse. There was a demonstrable antileukemic response in 13 patients. Nine patien
Background: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recr
Purpose: Incisional hernia repair (IHR) with a mesh is necessary to achieve low recurrence rates and pain relief. In the short term, quality of life (QoL) is restored by IHR. Two centers pioneered the IHR in Sweden with the highly standardized Rives–Stoppa technique using a retromuscular mesh. We assessed long-term follow-up of recurrence rate and QoL. Methods: Medical records were searched for IH
Floodwater harvesting (FWH) for artificial recharge of groundwater (ARG) and spate irrigation (SI) is the most widely practiced large catchment water harvesting technique. It has recently received renewed attention for research, improvement, and implementation. This chapter first introduces an innovative, locally adaptive, and improved FWH technique—floodwater spreading systems (FWS)—to guide poli
Background: Diabetic foot ulcers are a common and severe complication of diabetes mellitus. Standard treatment includes debridement, offloading, management of infection and revascularisation where appropriate, although healing times may be long. The LeucoPatch® device is used to generate an autologous platelet-rich fibrin and leucocyte wound dressing produced from the patient's own venous blood by
