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The importance of immunometabolism in the development of metabolic diseases is clear. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function, and vice versa, is poorly understood. Also, therapeutic strategies to harness the interplay between immune cells and metabolism are lacking. Here, we observe that ID rearranges the immune landscape of the liver,
Background: Multiple clinical practice guidelines and head computed tomography decision rules exist for emergency department (ED) triage of children with traumatic brain injury (TBI). These vary in structure, aim, target cohort, and outcomes, yet are used clinically in similar populations. We compared important clinical and practical characteristics of all major guidelines in a large, real-world p
Despite efforts to integrate BIM and BEM, challenges persist, including incomplete data, errors, and the need for manual corrections, all hindering the implementation of sustainable building designs. Professionals in the Swedish architecture, engineering, and construction (AEC) industry have yet to fully adopt standardized practices for exchanging BIM and BEM data. This article explores the challe
Market-based climate policies have received increased attention, making it important to understand how they affect competition in the electricity market. This paper focuses on the green certificate policy which financially supports producers of renewably sourced electricity by means of tradable certificates, and develops a duopoly model that incorporates both the electricity and the green certific
The European Association of Urology (EAU) 2021 prognostic model for non–muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Guérin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intr
Background: The multifactorial nature of chronic pain should be reflected in pain assessment. The aim of this observational study comparing samples from three generations assessed at different times was to present differences in pain, stress and mental well-being. Methods: Pain sites, widespread pain, stress (Perceived Stress Scale-4) and mental well-being (30-item General Health Questionnaire) we
Study region: The Limpopo River Basin (LRB) is a transboundary catchment in Southern Africa, shared by South Africa, Botswana, Zimbabwe, and Mozambique. The basin is increasingly affected by climate variability, land-use change, and rapid population growth, with the Chókwe floodplain in Mozambique representing a hotspot of socio-economic vulnerability to floods. Study focus: This study applies the
Improving energy efficiency in agriculture is key to reducing environmental impact. Lighting in animal buildings is one of the most cost‐effective energy saving measures. Lighting retrofit offers a short payback period, enhances animal welfare and production, and aligns with regulations for phasing out fluorescent lighting. The purpose of this study was to investigate the energy-saving potential o
Background: The international multi-center randomized controlled STEPCARE-trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out-of-hospital cardiac arrest (OHCA) patients due to various etiologies. The primary outcome is mortality at 6 months. This protocol describes an extended follow-up sub-study of the STEPCARE-trial wi
Background: Focal cortical dysplasia (FCD) is a developmental cortical malformation and a leading cause of drug-resistant epilepsy that often requires epilepsy surgery. Some FCD patients experience acute postoperative seizures (APOS) following surgery. The relationship between APOS and long-term prognosis for patients with FCD is at present unclear. The primary aim of this study was to analyze the
Supplemental Instruction has worked very well in various settings all over the world. It should be of interest to see if SI works at earlier stages than tertiary education. There are examples of successful SI programs at upper secondary schools, but no reports from lower secondary schools. This study evaluates a pilot SI program in a 7th and a 9th grade class in a socially challenged area with reg
Välkommen till framtiden! Men vilken framtid? Framtiden som begrepp är både mångtydigt och politiskt laddat. Å ena sidan framställs den som en naturlig förlängning av det förflutna och som något som kan planeras, styras och förutses. Å andra sidan öppnar begreppet framtider i plural för en kamp mellan olika visioner och en omförhandling av de historieskrivningar som legitimerar vissa framtider fraVälkommen till framtiden! Men vilken framtid? Framtiden som begrepp är både mångtydigt och politiskt laddat. Å ena sidan framställs den som en naturlig förlängning av det förflutna och som något som kan planeras, styras och förutses. Å andra sidan öppnar begreppet framtider i plural för en kamp mellan olika visioner och en omförhandling av de historieskrivningar som legitimerar vissa framtider fra
Autonomy is central to thinking about democracy and human needs, but the question of how autonomy relates to growth is ambivalent. Is growth necessary to achieve a basic level of autonomy, or is autonomy, in fact, a pre-requisite for post-growth? In this study, we examine this question by focusing on how critical autonomy relates to growth within the domains of democracy, education, and work. Crit
The Kunming-Montréal Global Biodiversity Framework, adopted at COP15, establishes a clear mandate to mobilize funding from diverse sources to address the escalating biodiversity crisis. Despite growing awareness and commitment to biodiversity conservation, a substantial financing gap persists, hindering efforts to protect and restore ecosystems effectively. This chapter provides an in-depth examin
The peak-hour travel demand is the most important operational cost driver for public transport in Sweden. Implementing staggered school starting hours as a measure to spread out the travel demand has proven to be challenging. This study focuses on overcoming barriers to collaboration between public transport authorities, municipalities, and schools concerning school transport planning and school o
Introduction: Neuromelanin containing cell loss, neuroinflammation and synaptic dysfunction are believed to contribute to Parkinson's disease (PD) pathogenesis. [18F]DOPA PET reflects dopamine storage capacity in the putamen, while midbrain off-target retention of [18F]RO948 is hypothesized to reflect neuromelanin. Objectives: To investigate associations between disease duration, cerebrospinal flu
BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14
Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based
Spectral electrical impedance tomography (sEIT) has attracted increasing interest in hydrogeology, biogeosciences, agriculture and environmental studies. However, broad-band sEIT measurements, particularly at frequencies above 50 Hz, have long been challenging due to electromagnetic (EM) coupling effects. Recent advances in instrumentation, data correction and filtering have improved sEIT measurem
Climate change can raise average temperatures and humidity and induce more frequent and stronger extreme weather events. This intensifies the need for studies on indoor climate and energy use in livestock buildings as it will affect animal welfare and farmers’ economy in terms of production, energy demand and needed investments. The aim of this review was to identify knowledge gaps and the need fo
